Interferons: Characterization, Mechanism of Action and Clinical Applications


Joe H. Thomas (Editor)
Adrian Roberts (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions, Immunology and Immune System Disorders
BISAC: SCI007000

Interferons are cytokines that are very important in regulating both innate and adaptive immune response. Of the two different types of interferons, Type I interferons are potent mediators of the innate immune response against viruses and cancer. Type II interferons, mainly IFN-y enhances T cell polarization in the lymph nodes that result in their expansion. This book discusses the characterization, mechanisms of action and clinical applications of interferons. Topics include interferon-gamma, oligodendrocyte injury and inflammatory demyelination; the role of IFN-y in esophageal squamous cell carcinoma; interferons in multiple sclerosis; the effect of interferons on NK cell activity in HIV infection and tumor cell development; and understanding the mechanisms of interaction between serine proteases, serine protease receptors and interferons. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Interferon Regulatory Factors in Immune Cell Development and Host Response to Infections
(Angela Battistini, Molecular Pathogenesis Unit, Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit¨¤, Rome, Italy)
Free Download Available 

Interferon-Gamma, Oligodendrocyte Injury and Inflammatory Demyelination
(David Liebenson, Roumen Balabanov, Rush University Medical Center, Department of Neurological Sciences, Multiple Sclerosis Center, Chicago, Illinois, USA)
Free Download Available

Interferons and their Effect on NK Cells Activity in HIV Infection and Tumour Cells Development
(Samuel Victor Nuvor, Department of Microbiology and Immunology, University of Cape Coast Medical School, Cape Coast, Ghana, West Africa)

Interferons, Serine Proteases and Protease-Activated Receptors: Enemies or Partners?
(Victoria Shpacovitch, Leibniz-Institute for Analytical Sciences-ISAS, Dortmund, Germany)

The Roles of IFN-¦Ã in Esophageal Squamous Cell Carcinoma
(Kenji Kawada, Masatoshi Akagami, Yoshiharu Sakai, Departments of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

Interferons in Multiple Sclerosis: Clinical Applications and Possible Mechanisms of Actions
(Konstantin Balashov, Department of Neurology, University of Medicine and Dentistry, New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA)

Dynamics of Lymphocyte Subpopulations in Patients with Chronic Hepatitis C Virus Infection during Pegylated Interferon-Alpha2a and Ribavirin Treatment
(Berta Soldevila, N¨²ria Alonso, Eva Mar¨ªa Mart¨ªnez-C¨¢ceres, Anna Sanmart¨ª, Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol. Badalona, Spain, and others)

Co-Delivery of Gamma Interferon Encodng Plasmid with DNA Vaccine Expressing Duck Hepatitis B Virus (DHBV) Proteins Enhances Therapeutic Potency of DNA-Based Immunization in Chronic Virus Carriers
(Fadi Saade, Thierry Buronfosse, Ghada Khawaja, Sylviane Guerret, Catherine Jamard, Michelle le Chevallier, Pierre Pradat, Fabien Zoulim, Lucyna Cova, Universit¨¦ Claude Bernard Lyon, France, and others)*

Rabies Virus Evasion of the Interferon System
(Martina Rieder, Lisa Drechsel, Karl-Klaus Conzelmann, Max von Pettenkofer-Institute & Gene Center, Munich, Germany)*



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