Inflammation and Chronic Disorders: The Secret Connection

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Ashwani K. Dhingra, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Priyanka Kriplani, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Bhawna Chopra, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Ajmer Singh Grewal, PhD – Associate Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Geeta Deswal, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Peeyush Kaushik, M. Pharm. – Assistant Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Series: New Developments in Medical Research
BISAC: MED071000; MED072000; TEC072000
DOI: https://doi.org/10.52305/KHEF3346

Inflammation is a protective mechanism of the body in which the immune system identifies, rejects, and kick-starts the healing process after damage caused by injurious stimuli, such as pathogens, irritants or injured cells. During inflammation diverse pathological changes take place which trigger to generate the active inflammatory mediators by host proteins, like complement proteins or kinins. Inflammatory cells are activated by both infectious and non-infectious stimuli, as well as by cell injury, which also triggers inflammatory signalling pathways, most often the NF-κB, MAPK, and JAK-STAT pathways. However, sometimes the immune system triggers the inflammatory process even in the absence of foreign substances, resulting in the development of harmful conditions, e.g., inappropriate regulation of NF-κB results in the development of serious illnesses like cancer, septic shock, neurodegenerative disorders, etc. However, its origins and consequences are still uncovered to understand its involvement in many human diseases.

This book is comprised of 15 chapters written by leading researchers in the field, covering a broad range of topics to highlight the fundamental reasons and the astonishing association of inflammation with the onset of various diseases or illnesses. A prolonged inflammation procedure involving the destruction of tissue and fibrosis at the same interval of time is regarded as chronic inflammation, which can be characterized by the expansion of both humoral and cellular immune responses against pathogens. In addition, numerous mediators contribute inflammation process; few are released without delay (serotonin, histamine etc.), few are secreted within an interval of short time (leukotrienes, prostaglandins, etc.), a few entail the de novo synthesis (interferon, interleukin, growth factors, etc.). Both pro and pre-cytokines that initiate inflammation like tumour necrosis factor, interferon, interleukin 1β, and oxidative stress promote inflammation by stimulation of gene expression which depends on the availability of interacting sites for the nuclear factor kappa activated B cells. The anti-inflammatory strategies showed a significant reduction in the average risk of developing Alzheimer’s disease, arthritis, autoimmune disorders, cancer, etc. The successful exploration of new fundamental causes and their relationship with inflammation enlightens multi-targeting alternatives to treat certain various illnesses; evokes researchers to develop a safe and effective therapeutic regimen; thus, promoting health benefits.

Table of Contents

Preface

Chapter 1. Inflammation: The Secret Killer Behind Various Life-Threatening Diseases
Ashwani K. Dhingra, Bhawna Chopra, Geeta Deswal, Priyanka Kriplani, Peeyush Kaushik, Ajmer Singh Grewal and Kumar Guarve
Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 2. Inflammation and Alzheimer’s Disease
Payal Chauhan, Karan Wadhwa and Govind Singh
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

Chapter 3. Inflammation and Cancer
Amisha Chauhan and Shikha Baghel Chauhan
Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 4. Inflammation and Allergic Disorders
Sachin Gulia, Payal Chauhan and Govind Singh
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

Chapter 5. SARS-CoV-2 and Inflammation: An Overview
H. K. Sundeep Kumar1, Priyadarshini Mishra1, Mrityunjay Banerjee1, Sujit Ku. Sahu1 and Suman Acharyya2
1
Institute of Pharmacy & Technology, Salipur, Odisha, India
2Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Chapter 6. The Secret Connection Between Inflammation and Alzheimer’s Disease (AD)
Shaima K. A.1, Sakshi Ramesh Gorivale2, Manoj Kumar Mishra1 and Sarita Jangra2
1
Department of Pharmacy Practice, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India
2Department of Pharmacy Practice, Chitkara College of Pharmacy, Chitkara University, Punjab, India

Chapter 7. Inflammation and Metabolic Syndrome
Sanchit Dhankhar1, Samrat Chauhan1, Nitika Garg6, Geeta Deswal3, Monika Saini2, Sumit Sharma5, Manni Rohilla4, Sonam Grewal2 and Prerna Sarup4
1
Chitkara College of Pharmacy, Chitkara University, Punjab, India
2M. M. College of Pharmacy, M. M. (Deemed to be University), Mullana, Ambala, Haryana, India
3Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
4Swami Vivekanand Institute of Engineering and Technology, Ramnagar, Rajpura, Punjab, India
5University Institute of Pharma Sciences, Chandigarh University, Gharuan, Punjab, India
6Ganpati Institute of Pharmacy, Bilaspur, Yamunanagar, Haryana, India

Chapter 8. Inflammation and Traumatic Brain Injury
Mohit Kumar1,2, Jasmine Chaudhary1 and Akash Jain1
1
M.M. College of Pharmacy, M.M. (Deemed to be University), Mullana, Ambala, Haryana, India
2Ch. Devi Lal College of Pharmacy, Bhagwangarh, Jagadhri, Haryana, India

Chapter 9. The Influence of Inflammation on Ischemic Strokes
Karan Wadhwa, Payal Chauhan and Govind Singh
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

Chapter 10. Uterine Fibroids and Associated Chronic Inflammation
Kiran Sharma
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, Uttar Pradesh, India

Chapter 11. Neuroinflammation and Alzheimer’s Disease
Shikha Raheja and Amit Girdhar
Jan Nayak Chaudhary Devi Lal Memorial College of Pharmacy, Sirsa, Haryana, India

Chapter 12. Inflammatory Breast Cancer
Dibya Sundar Panda1, Ranjan Kumar Giri2 and Mrityunjay Banerjee2
1
College of Pharmacy, Jouf University, Sakaka, Saudi Arabia
2Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India

Chapter 13. Inflammation and Arthritis
Kunal Kanojia, Anushka Tyagi and Parul Grover
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, Uttar Pradesh, India

Chapter 14. Inflammation and Diabetes
Sanjana Mehta1, Divya Kanwar1, Parminder Nain2, Jaspreet Kaur2 and Samrat Chauhan1
1
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India
2CT Institute of Pharmaceutical Sciences, South Campus, Shahpur, Jalandhar, India

Chapter 15. The Causes, Symptoms and Treatments of Inflammatory Heart Diseases
Ajit Kumar Varma1, Mamta Yadav2 and Arpita Chaudhary1
1
Faculty of Pharmaceutical Sciences, Rama University, Mandhana, Kanpur, Uttar Pradesh, India
2Bansal College of Pharmacy, Bhopal, Madhya Pradesh, India

Index

About the Editors

 


Editor’s ORCID iD

Ashwani K. Dhingra 0000-0001-7574-2971
Priyanka Kriplani 0000-0003-2250-9169
Bhawna Chopra 0000-0003-2251-2034
Ajmer Singh Grewal 0000-0002-2418-9616
Geeta Deswal 0000-0003-3648-0643
Peeyush Kaushik 0000-0002-3052-1734

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