Implication of Regulatory Cells on Immune Tolerance

Carol Aristimuño, Roseta Teijeiro, Clara de Andrés and Silvia Sánchez-Ramón
Universitario Gregorio Marañón, Madrid, Spain, and others

Series: Cell Biology Research Progress, Immunology and Immune System Disorders
BISAC: SCI017000



Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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The immune system is a biological homeostatic system that maintains the immunological equilibrium trough central and peripheral tolerance mechanisms. Central tolerance occurs very early in the development at the primary lymphoid organs, the thymus and the bone marrow for T and B lymphocytes, respectively, where most potentially threatening autoreactive lymphocytes with high avidity for the autoantigen are eliminated. This book summarizes research characterizing the growing diversity of immunorregulatory cells subsets in the control of autoimmunity in rodents and humans, with an attempt to integrate the current experimental evidence on the major suppressive pathways of immunorregulation. (Imprint: Nova)


Immunological tolerance

Tolerogenic macrophages

Immunogenic versus tolerogenic dendritic cells

Regulatory T Cells: Natural versus induced

Tr1: Interleukin-10 (IL-10)-secreting Tr1 CD4+ T cells

Th3 lymphocytes

Regulatory/Suppressor CD8+ T-Lymphocytes

Regulatory Natural Killer Cells

Conclusions and future perspectives




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