Carol Aristimuño, Roseta Teijeiro, Clara de Andrés and Silvia Sánchez-Ramón
Universitario Gregorio Marañón, Madrid, Spain, and others

Series: Cell Biology Research Progress, Immunology and Immune System Disorders
BISAC: SCI017000

The immune system is a biological homeostatic system that maintains the immunological equilibrium trough central and peripheral tolerance mechanisms. Central tolerance occurs very early in the development at the primary lymphoid organs, the thymus and the bone marrow for T and B lymphocytes, respectively, where most potentially threatening autoreactive lymphocytes with high avidity for the autoantigen are eliminated. This book summarizes research characterizing the growing diversity of immunorregulatory cells subsets in the control of autoimmunity in rodents and humans, with an attempt to integrate the current experimental evidence on the major suppressive pathways of immunorregulation. (Imprint: Nova)