Immunological Pathogenesis of Sepsis and Use of Hemosorption for Treatment of Cancer Patients with Sepsis

Natalia Yu. Anisimova, PhD (Editor)
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences (N.N. Blokhin RCRC, RAMS), Moscow, Russia

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED058160

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This monograph summarizes the data of the prospective study on the immunological characteristics of cancer patients with sepsis and septic shock developed after surgery. Patients without signs of infectious complications and symptoms of organ failure, as well as a group of healthy donors, were considered as references. The comparative analysis of blood parameters that characterized humoral and cell immunity (concentrations of cytokines and their receptors, immunoglobulins, lipopolysaccharide and other active biomolecules) has been performed.

An estimation of diagnostic and prognostic significances of these parameters has been performed as well. In the final chapters, the properties of the new perspective hypercrosslinked polymeric hemosorbents are presented. The monograph could be interesting for a wide array of specialists in the fields of resuscitation, healthcare therapy, oncology and surgery, as well as for researchers aimed toward the development of new types of biocompatible materials.

(Imprint: Nova Biomedical )

Introduction

Chapter 1.Immunological Pathogenesis of Sepsis: Diagnostic and Prognostic Markers of Sepsis
(N. Yu. Anisimova, A. Yu. Grebenko, E.G. Gromova, L.S. Kuznetsova, J.I. Dolzhikova and M.V. Kiselevsky, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation)

Chapter 2. Pathomorphology of Sepsis
(O.V. Lebedinskay and A.N. Kopylov, EA Vagner Perm Medical Academy, Department of Histology, Embryology and Cytology, Perm, Russia and others)

Chapter 3. Use of Hemosorption in Treatment of Cancer Patients: Effectiveness of Different Devices
(N. Yu. Anisimova, A. Yu. Grebenko, E.G. Gromova, L.S. Kuznetsova and M.V. Kiselevsky, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation)

Chapter 4. Detoxification of Blood and Plasma by Means of Hypercrosslinked Polymeric Hemosorbents: State-of-the-Art
(V.A. Davankov, M.P. Tsyurupa and L.A. Pavlova, A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russian Federation)

Chapter 5. An Experience of Application of the Device Based on the Hemosorbent Styrosorb 514 in Treatment of Dogs with Sepsis (Pilot Study)
(N. Yu. Anisimova, V.A. Davankov, M.P. Tsyurupa, L.A. Pavlova, E. A. Kornjushenkov, E.V. Zakharov, N. V. Ustyuzhanina and M.V. Kiselevsky, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation and others)

Conclusion

Index

"Dr. Natalia Anisimova is an outstanding immunologist at the Blockin Russian Cancer Research Center in Moscow, headed by Prof. Kesilievsky. An outstanding author, Dr. Anisimova brings her vast knowledge in chemistry, biology, and clinical application into this text. In this most recent book written by Dr. Anisimova, she deals with the pathological condition of sepsis." READ MORE... - Gianfranco Baronzio, MD, Scientific director of LM Cell Factory, Terni, Italy

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