Immune System Dominant Role in Tissue Homeostasis, Neo-Oogenesis, Regenerative Medicine, and Cancer Growth and Treatment

Antonin Bukovsky
Academy of Sciences of the Czech Republic, Institute of Biotechnology, Vestec at Prague, Prumyslova, Czech Republic

Series: Cancer Etiology, Diagnosis and Treatments
Obstetrics and Gynecology Advances

BISAC: MED062000




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The dominant role of the immune system in managing homeostasis of distinct normal tissues and in stimulating cancer growth in regenerative medicine for gonadal infertility and aging diseases, effective immunotherapy without adverse events of inoperable epithelial ovarian cancers (EOCs), and long-lasting cancer immune prophylaxis are reported. Beside their well–known role in immunity, the blood mononuclear cells belong to the complex tissue control system, where they serve the homeostatic function by stimulating the proliferation of tissue stem cells followed by cellular differentiation, which is stopped after attaining the tissue-specific functional stage. Transfused blood from young donors could temporarily restore fertility in infertile individuals and alleviate aging diseases.

This can be enhanced by the honey bee propolis that activates the thymus. An additional promising aspect for neuronal, vascular, and heart disorders is combination of sex steroids stimulating proliferation and differentiation of endogenous stem cells. Growth of cancers exhibiting expression of allogeneic antigens, is in vivo enabled by fusion of cancer cells with the host cells. This mechanism is physiologically reserved for the mammalian ability to support implantation of allogeneic embryo and fetal growth. Treatment of EOCs conventionally consists of cytoreductive surgery and platinum-based chemotherapy, but 80% of patients experience relapses with a median progression-free survival of 12 to18 months. So, the prevention of relapses, particularly in EOCs, remains problematic. Beside partial improvement of cancer treatment by immune checkpoint inhibitors that, however, cause adverse events ranging from mild to lethal, the EOCs exhibit objective reply in about 10% only.

Previous preclinical experiments indicate that the combination of systemic cyclophosphamide with intradermal injections of bacterial toxins and allogeneic sensitization by white blood cells may be an effective immunotherapy for human cancers. Treatments with intermittent doses of cyclophosphamide, combined with intradermal bacterial toxins and blood transfusions, eliminates host antibodies blocking anticancer T cell effectors, enhances anticancer immune reactivity, and augments immune reactivity against alloantigens of cancer cells. This approach was not accompanied by any adverse events and resulted of regression of inoperable EOCs and regeneration of abdominal cavity tissues affected by cancer metastases during the subsequent treatment-free periods. Untreated colorectal cancer regressed after severe toxic dermatitis lasting over one week caused by an accidental ingestion of the raw shiitake mushroom. Subsequent weekly ingestions of the raw shiitake mushroom containing lentinan, accompanied with daily metformin, both stimulating immune reactivity against cancer stem cells, resulted in cancer prophylaxis over 25 years, without any recurrent dermatitis. Effective immunotherapy without side effects for advanced inoperable cancers, accompanied by regeneration of metastatically altered tissues, and long-lasting immune prophylaxis of cancers is the goal of our approach.

Given the poor outcomes of patients with advanced EOCs and former reports of successful treatments using immunologic enhancement, this area needs to be re-visited with modern clinical trials. Immune system preparations for EOC rejection without adverse events may be effective during subsequent treatment-free period, when the sensitized immune system is able to reject cancer cells without being otherwise influenced. The extended survival of cancer patients could be achieved by continuous use of substances maintaining long-term immune reactivity against cancer stem cells.
(Imprint: Nova Medicine and Health)



Chapter 1. Introduction

Chapter 2. The Role of the Immune System in Homeostasis of Normal Tissues

Chapter 3. Maintenance of Tissue Homeostasis by Tissue Control System

Chapter 4. Immune System Involvement in the Regulation of Ovarian Function

Chapter 5. Ovarian Stem Cell Cultures

Chapter 6. Proposals for Ovarian Infertility Treatment

Chapter 7. Systemic Treatment of Other Functional Diseases by Tissue Rejuvenation
Chapter 8. Conclusions on Tissue Homeostasis, Including the Ovary

Chapter 9. Novel Options in Regenerative Medicine

Chapter 10. Immunological Homeostasis of Cancer

Chapter 11. Immunotherapy of Advanced Inoperable EOCS without Adverse Events

Chapter 12. Long Lasting Cancer Survival Depends on an Effective Prevention of Cancer Relapses



Keywords: Aging diseases, Cancer growth, Cancer immunotherapy, Cancer prophylaxis, Cell biology; Ovarian infertility, Ovarian neo-oogenesis, Regenerative medicine, Tissue homeostasis

Book is written for professionals dealing with the immune system role in tissue homeostasis, including ovarian function and gonadal infertility, regenerative medicine, effective immunotherapy of ovarian and other advanced cancers, and long lasting immune prophylaxis of cancer recurrences by substances supporting immune system reactivity against cancer stem cells.
It will be helpful if pharmaceutical industries will deal with production of retroplacental blood IgG that is effective in inhibiting production of host antibodies blocking cancer patient cytotoxic T cells against their cancer cells. They have also support the production of Bacterinum adnexitidicum (BA)/SEVAC (also known as Adnexba) containing toxins from Enterococci, Escherichia Coli, Neisseria Gonorrhoeae, Staphylococcus Aureus, and Streptococci, that were highly effective component, along with other approaches, in the elimination of advanced inoperable EOCs, accompanied by regeneration of metastatically altered tissues during the subsequent treatment-free period, when the sensitized immune system is able to reject cancer cells without being otherwise influenced. Furthermore, the pharmaceutical extracts from shiitake and other mushrooms exhibiting anticancer effects should be prepared without using higher temperatures, e.g., warm water, which will affect thermolabile components, like is the lentinan.

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