Hypotheses in Clinical Medicine

Mohammadali Shoja (Editor)
Tabriz University of Medical Sciences, Tabriz, Iran

Paul S. Agutter, M.D., Ph.D. (Editor)
Theoretical Medicine and Biology Group, Glossop, Derbyshire, United Kingdom

R. Shane Tubbs, Ph.D. (Editor)
Children’s of Alabama, Birmingham, Alabama, US

Mostafa Ghanei (Editor)
Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran

Kamyar Ghabili (Editor)
Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Alon Harris (Editor)
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, US

Marios Loukas, M.D., Ph.D. (Editor)
Department of Anatomical Sciences, St. George’s University, Grenada

Series: Medical Procedures, Testing and Technology, Laboratory and Clinical Research
BISAC: MED014000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Hypotheses are fundamental to all sciences, including medicine. They play a critical role in motivating the development of science, since interesting and important hypotheses foster the diversity and debate upon which the scientific process depends. It is necessary to learn and understand how to assess a process, realize and discuss details and consequently launch a hypothesis. This book offers a number of novel, non-mainstream hypotheses – in various states of development – from authors with relevant expertise and experience.


Preface: Hypotheses in Clinical Medicine
(Mohammadali M. Shoja, Paul S. Agutter, R. Shane Tubbs, Mostafa Ghanei, Kamyar Ghabili Alon Harris, Marios Loukas)

Chapter 1: From Hypothesis to Evidence-Based Medicine: Connecting the Dots
(Bradley K. Weiner, Joseph Fernandez-Moure, Ennio Tasciotti, Mohammadali M. Shoja)

Chapter 2: Paradigm Shifts and Explanation in Clinical Medicine: The “How” of Reality and the “Why” of Truth
(Alireza Ghaffari, Mohammadali M. Shoja, R. Shane Tubbs, Marios Loukas, Paul S. Agutter, Kamyar Ghabili, Jalal Etemadi, Aaron A. Cohen-Gadol, Bradley K. Weiner)

Chapter 3: Data Management Using Computational Methods to Put the Pieces Together: Time to Move from Theory to Practice
(Virginia A. Folcik, Rubina Kapil, Keith Warren, Clay B. Marsh, William T. Coleman)
Free Download Available

Chapter 4: Could Cytomegalovirus be Causing Widespread Outbreaks of Chronic Poor Health?
(Rodney P. Jones)

Chapter 5: The Cold Chain Hypothesis: An Update
(Ulrich Meinzer, Frederick Barreau, Jean-Pierre Hugot)

Chapter 6: Reflections on Pellagra: Lessons and Hypotheses for Diseases Ancient and Modern
(Adrian C. Williams, Lisa J. Hill, David B. Ramsden)

Chapter 7: Population Genetics, Cancer Cell Growth and Cancer Evolution
(Christopher Naugler)

Chapter 8: Organism Mutation Stability and Cancer
(Edward A. Rietman, J. Tyson McDonald, Lynn Hlatky)

Chapter 9: The Growths of Most Cancers are Driven by Tumor-Stimulating Immune Reactions
(Raúl A. Ruggiero, Paula Chiarella, Juan Bruzzo, Liisa M. Prehn, Richmond T. Prehn)

Chapter 10: Complexity: Is it the Real Language of Prostate Cancer?
(Fabio Grizzi, Gianluigi Taverna, Pier Carlo Muzzio, Pierpaolo Graziotti)

Chapter 11: New Hypotheses Concerning Cancer Carriage with Special Reference to Intracranial Lymphatic Connection
(Wilson I.B. Onuigbo)

Chapter 12: A Proposal for a New Strategy in the Treatment of Head and Neck Cancer: Combination Chemotherapy Targeting the PI3kinase/Akt and EGFR Signaling Pathways
(Yuh Baba, Masato Fujii, Yutaka Tokumaru, Yasumasa Kato)
Free Download Available

Chapter 13: Individualized Cancer Chemotherapy
(Da-Yong Lu, Ting-Ren Lu, Xue-Liang Chen, Jian Ding)

Chapter 14: The Potential Evolutionary Significance of the Pineal Gland
(Paul S. Agutter, R. Shane Tubbs, Marios Loukas, Mehdi Farhoudi, Alireza Ghaffari, Martin M. Mortazavi, Kamyar Ghabili, Mohammadali M. Shoja)

Chapter 15: Cytoskeletal Proteins as Drug Development Targets for Various Diseases
(Nancy J. Woolf, Avner Priel, Jack A. Tuszynski)

Chapter 16: Why do We Yawn? Past and Current Hypotheses
(Olivier Walusinski

Chapter 17: Regressive Autism and Defective Evolution of Cerebral Laterality
(Matteo Chiappedi)

Chapter 18: The Human Sensory Processing Sensitivity: Biological Implications for Introversion, Submission and Creativity
(Carlos V. Rizzo-Sierra)

Chapter 19: Are the Systemic Arterial Blood, Intracranial and Intraocular Pressures Co-regulated?
(Mohammadali M. Shoja, Alon Harris, Yochai Shoshani, R. Shane Tubbs, Brent A. Siesky, Christoph J. Griessenauer, Marios Loukas, Paul S. Agutter, Barbara M. Wirostko, Aaron A. Cohen-Gadol)

Chapter 20: Pathophysiological Basis for Anti-Hypertensive Effects of Antioxidants and the Role of Oxidative Stress in Essential Hypertension
(Ramón Rodrigo, Andrés Miranda-Merchak, Jaime González)

Chapter 21: Deep Venous Thrombosis: Etiology and Prophylaxis
(Mark P. Henderson)

Chapter 22: Pathogenesis of Preeclampsia and the Preventive Role of L-Arginine Supplementation
(Ramón Rodrigo, Jaime González, Rodrigo Valenzuela)

Chapter 23: A Unified Hypothesis for the Pathogenesis of Chronic Obstructive Pulmonary Disease and Atherosclerosis: The Role of Microvascular Flow Insufficiency and Functional Hypoxia
(Pentti Tuohimaa, Matti Järvilehto)
Free Download Available

Chapter 24: Oral Foci in Systemic Diseases
(Shailesh M. Gondivkar, Amol R. Gadbail, Rima V. Parikh)

Chapter 25: Stress and the Flaws of the Stress Response: The Good, the Bad and the Ugly in the Evolution of the Stress Response
(Deepak Kumar Singh, Lekha Tuli)

Chapter 26: Outbreaks of Red Mite (Dermanyssus gallinae) Dermatitis in City-Dwellers: An Emerging Urban Epizoonosis
(Maria Assunta Cafiero, Antonio Camarda, Domenico Galante, Giuseppe Mancini, Elena Circella, Nicola Cavaliere, Gianfranco Santagada, Mauro Caiazzo, Michele Lomuto)
Free Download Available

Chapter 27: House Dust Mites Do Not Live in House Dust: Evidence and Implications for the Current Understanding of House Dust Mite Allergy
(Thorkil E. Hallas)

Chapter 28: The Role of UV Irradiation in the Progression of Diabetic Retinopathy
(Liat Avdian, Alon Harris, R. Shane Tubbs, Marios Loukas, Ghaffar Shokouhi, Kamyar Ghabili, Paul S. Agutter, Brent A. Siesky, Yochai Shoshani, Mohammadali M. Shoja)

Chapter 29: Nonalcoholic Steatohepatitis Revisited by Crossing the Boundaries between Physical Chemistry and Histomorphology
(Sven Gunia, Andreas Erbersdobler)

Chapter 30: Is the Iliotibial Band Syndrome Really a Friction Syndrome?
(Frederick Michels, Jan Van Der Bauwhede, Stéphane Jambou)

Chapter 31: Thirty Years Lost in Medical Theory: Hans Selye’s Unified Theory of Medicine and the Stress Repair Mechanism
(Lewis S. Coleman)


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