Hyperalgesia and Allodynia: A Closer Look. Symptoms, Mechanisms and Treatment


Merab G. Tsagareli, PhD, DScHead, Lab of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia

Series: Pain Management – Research and Technology, Pharmacology – Research, Safety Testing and Regulation
BISAC: MED093000

Pain and itch are associated with a wide range of injuries and diseases. Some conditions may have pain and associated symptoms arising from a discrete cause, such as postoperative and neuropathic pains or headaches. Chronic itch or pruritus is a frequent symptom in the general population and in many skin and systemic diseases. Millions of people on the planet suffer from acute or chronic pain and itch every year, and the effects of pain and itch exact a tremendous cost on most countries concerning health care costs, rehabilitation and lost worker productivity, as well as the emotional and financial burden it places on patients and their families. Therefore, the synthesis and development of a new generation of analgesic drugs with lesser side effects are very important for society.

This book provides an original account of behavioral, cellular and molecular aspects with important ramifications for the study of hyperalgesia and allodynia in pain and itch. It concentrates on the role of transient receptor potential (TRP) channels functioning in pain and itch states. It explains how TRP channels work in terms of specified somato-sensory mechanisms and systems. This book shows that TRP channels are promising targets for the development of a new group of analgesic drugs at the periphery and central levels and opportunities for therapeutic intervention.

Table of Contents

Table of Contents


Chapter 1. Allodynia and Hyperalgesia in Pain Sensation: Prefatory Chapter
(Merab G. Tsagareli, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia)

Chapter 2. Alloknesis and Hyperknesis: Sensitization for Itch
(Kristen M. Sanders and Tasuku Akiyama, Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, US, and others)

Chapter 3. Assessment of Allodynia, Hyperalgesia and the Parallel Itch-Associated Phenomena Alloknesis and Hyperknesis in Human Skin
(Hjalte Holm Andersen and Silvia Lo Vecchio, Laboratory of Experimental Cutaneous Pain and Itch Research, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark)

Chapter 4. Gut Hypersensitivity: A Complex Network of Voltage-Gated Na+ Channels
(Julio Alvarez-Collazo and Karel Talavera, Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium)

Chapter 5. Modeling Nociceptors
(Sergiy M. Korogod, O. O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine)

Chapter 6. DNA Methyltransferases as a Target for Chronic Pain Treatment
(Elene Abzianidze, Eka Kvaratskhelia, Maia Zarandia, Ketevan Dzagoevi, Tinatin Tkemaladze, Gulnaz Gurtskaia, Nana Tsiklauri and Merab G. Tsagareli, Department of Molecular and Medical Genetics, State Medical University of Tbilisi, Georgia, and others)

Chapter 7. Agonist-Evoked Hyperalgesia and Allodynia: The Role of Transient Receptor Potential Channels in Pain and Itch
(Ivliane Nozadze, Gulnaz Gurtskaia, Nana Tsiklauri and Merab G. Tsagareli, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia)


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