Hydroxyapatite and Other Calcium Orthophosphates: Biocomposites, Self-Setting Formulations and Dissolution

Sergey V. Dorozhkin
Moscow, Russia

Series: Biomaterials – Properties, Production and Devices
BISAC: TEC021000

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As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications of CaPO4 as biocomposites and hybrid biomaterials, self-setting formulations, as well as the workings of their dissolution mechanism. Topics discussed include the major constituents of biocomposites and hybrid biomaterials for bone grafting, preparation, properties and the available knowledge on interactions among the phases for various types of CaPO4-based biocomposites. Additionally, the major types, preparation, properties and the available knowledge on the reinforced formulations for various types of self-setting CaPO4-based compositions, followed by the detailed description of their biomedical applications and in vivo behavior are discussed. The comprehensive description of currently available dissolution mechanisms of calcium apatites in acids, followed by the successful attempt to create the general dissolution mechanism is given in the last section of this book. (Imprint: Nova)

Preface

Abbreviations

PART I. Calcium Orthophosphate (CaPO4)-Containing Biocomposites and Hybrid Biomaterials

Chapter 1. Introduction

Chapter 2. General Information and Knowledge

Chapter 3. The Major Constituents of Biocomposites and Hybrid Biomaterials for Bone Grafting

Chapter 4. Biocomposites and Hybrid Biomaterials Based On Capo4

Chapter 5. Interactions among the Phases in Capo4-Based Formulations

Chapter 6. Bioactivity and Biodegradation of Capo4-Based Formulations

Chapter 7. Some Challenges and Critical Issues

Chapter 8. Conclusions

References

PART II. Self-Setting Calcium Orthophosphate (Capo4) Formulations

Chapter 9. Introduction

Chapter 10. General Information and Knowledge

Chapter 11. Three Major Types of the Self-Setting Capo4 Formulations

Chapter 12. Various Properties

Chapter 13. Bioresorption and Replacement of the Self-Setting Capo4 Formulations by Bones

Chapter 14. The Mechanical Properties

Chapter 15. Reinforced Capo4 Formulations and Concretes

Chapter 16. Biomedical and Clinical Applications

Chapter 17. Non-Biomedical Applications

Chapter 18. Recent Achievements and Future Developments

Chapter 19. Conclusions

References

PART III. The Dissolution Mechanism of Calcium Apatites in Acids

Chapter 20. Introduction

Chapter 21. Critical Analysis of the Dissolution Models of Calcium Apatites

Chapter 22. Summary on the Dissolution Models

Chapter 23. A Reasonable Classification of the Dissolution Models

Chapter 24. Brief Information on Apatite Structure

Chapter 25. Necessary Assumptions and Limitations

Chapter 26. Creation of the General Dissolution Mechanism

Chapter 27. Conclusions

References

Author Contact Information

Index

Part I

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Part III

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