Hyaluronan: Biological and Medical Implications

Vitor H. Pomin (Editor)
Biochemistry and Chemical Biology, Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Series: Biochemistry Research Trends
BISAC: SCI007000

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Hyaluronan or hyaluronic acid (HA), the only non-sulfated glycosaminoglycan (GAG) of the body, is structurally composed of disaccharide repeating units of alternating 3-linked N-acetyl β-D-glucosamine and 4-linked β-D-glucuronic acid. Despite the lack of sulfation and the lowest structural heterogeneity among all GAGs, HA still retains efficient capability in interacting with many molecules, especially functional proteins like growth factors, cytokines, and adhesive proteins involved in angiogenesis, tumor proliferation, migration and invasion. However, the main biological role of HA is to assemble the extracellular matrices of certain soft tissues, such as vitreous humor, synovial fluid, umbilical cord and the intercellular space of the epidermis. HA is the major structure-forming component in the globe of the eye and cornea. For this reason, this GAG can be used to compose ophthalmic solutions.

The most famous physicochemical property of HA is its capacity to make gels in solution. This property can be pharmaceutically and industrially useful as either a vehicle to make specific media or biologically active sera. This book, heavily based on recent scientific results from research groups of several countries, will cover many of these aspects of HA, the related enzymes and metabolism in health and disease. The seven chapters are basically centered in 1) the covalent modifications of HA by serum protein and the biological consequences; 2) the aspects of HA as a function of age; 3) carcinogenesis as a function of HA metabolism; 4) therapeutic applications of HA-related enzymes; 5) characterization and analyses of HA-based ophthalmic solutions; 6) the role of HA in reproductive medicine; and 7) the role of HA in bone medicine. The contributing authors are renowned scientists in the HA field and this collaborates to the high-quality of this publication. (Imprint: Nova)

Preface

Chapter 1 - Covalent Modification of Hyaluronan by Serum Protein and Its Biological Consequence (pp. 1-14)
Lisheng Zhuo and Koji Kimata (Advanced Medical Research Center, Aichi Medical University, Nagakute, Aichi, Japan)

Chapter 2 - Aging and Hyaluronan (pp. 15-30)
Mamatha Damodarasamy and May J. Reed (Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, US)

Chapter 3 - Biological Synthesis and Catabolism of Hyaluronic Acid during Carcinogenesis (pp. 31-52)
Rajeev K. Boregowda and Shib Das Banerjee (Department of Medicine, Medical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, NJ, US and others)

Chapter 4 - Hyaluronidases: Biological Features and Current Therapeutic Applications (pp. 53-84)
R. Gazzola, G. Colombo, S. Marcelli and L. Vaienti (Plastic Surgery Department, I.R.C.C.S. Policlinico San Donato – Università degli Studi di Milano, Piazza Malan, San Donato Milanese, Italy)

Chapter 5 - In vitro Characterization and Ophthalmic Applications of Hyaluronan (pp. 85-112)
X. Michael Liu, Patricia S. Harmon, E. Peter Maziarz and John W. Sheets (Global Research & Development, Bausch & Lomb, Rochester, NY, US and others)

Chapter 6 - The Role and Use of Hyaluronan in Reproductive Medicine (pp. 113-138)
Barbara Pregl Breznik, Borut Kovačič and Veljko Vlaisavljević (Department for Reproductive Medicine and Gyneacologic Endocrinology, University Medical Center Maribor, Slovenia)
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Chapter 7 - Hyaluronan-Coated Bone Graft Substitutes and Their Osteoconductive Properties (pp. 139-148)
Stephan Reitinger, Robert G. Stigler and Günter Lepperdinger (Institute for Biomedical Aging Research, University of Innsbruck, Austria)

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