Huntington’s Disease: Symptoms, Risk Factors and Prognosis

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Kevin Guillory (Editor)
Alex M. Carrasco (Editor)

Series: Neurodegenerative Diseases – Laboratory and Clinical Research
BISAC: MED057000

Huntington’s disease (HD) is a progressive, neurodegenerative genetic disorder characterized by motor dysfunctions, cognitive decline, and psychiatric symptoms. In this book, the authors discuss the symptoms, risk factors and prognosis in Huntington’s disease. Topics include the pathogenic mechanisms by which the expanded polyglutamine huntingtin causes neuronal dysfunction and death and the potential therapeutic strategies recently developed for this incurable disorder; the role of brain-derived neurotrophic factor in Huntington’s disease; and the legal ramifications in relation to evolving impairments of capacity which can have an outcome in terms of involuntary status as mental health patients, testamentary capacity and the need for guardianship and administration orders. (Imprint: Nova Biomedical )

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Table of Contents

Preface

Huntington’s Disease: From Disease Pathogenesis to Clinical Perspectives
(Sara Parodi, Maria Pennuto, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy)

The Role of Brain-Derived Neurotrophic Factor (BDNF) in Huntington’s Disease: Trophic Support as a Therapeutic Strategy
(Patricia S. Brocardo, Joana Gil-Mohapel, Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada, and others)

The Legal Ramifications of Huntington’s Disease
(Ian Freckelton, Melbourne Law School and Department of Psychiatry, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Australia)

Index

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