Huntington’s Disease: Prevalence, Pathogenesis and Treatment

$130.00

Christina Hughes (Editor)

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED056000

Huntington’s disease (HD) is a progressive, fatal, dominant inherited neurodegenerative disorder caused by an unstable expansion of CAG repeats within the coding region of the IT15 gene that encodes for a protein called huntingtin (htt). The clinical hallmark of HD is a severe motor impairment, but cognitive and psychiatric symptoms are early clinical features in HD that often appear before the onset of motor signs. This book discusses the prevalence, pathogenesis and treatment of HD. (
(Imprint: Nova Biomedical)

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Table of Contents

Table of Contents

Preface

Chapter 1. Pathogenesis of Neuronal Dysfunction in Huntington’s Disease: Defining the Molecular Mechanisms to find New Treatments
L. Vidal-Sancho, N. Cabezas-Llobet, M. Anglada-Huguet, J. Alberch and X. Xifró (TargetsLab, Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain, and others)

Chapter 2. The Clinical Features of Huntington’s Disease
Annie Killoran (Department of Neurology, University of Iowa, Iowa City, Iowa, USA)

Chapter 3. The Huntington’s Disease Protein Participation in the Nucleo-Shuttling of the ATM Kinase
Mélanie L. Ferlazzo and Nicolas Foray (Institut National de la Santé et de la Recherche Médicale Unit, Radiobiology Group, Cancer Research Centre of Lyon, Lyon, France)

Chapter 4. Are Antioxidants Good Therapeutic Candidates for Huntington’s Disease?
Joana Gil-Mohapel (Division of Medical Sciences and UBC Island Medical Program, University of Victoria, Victoria, BC, Canada)

Chapter 5. Modeling Huntington’s Disease in Transgenic Animals
Patricia S. Brocardo and Joana Gil-Mohapel (Department of Morphological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis-SC, Brazil, and others)

Index

Additional information

Binding

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