Human Serum Albumin (HSA): Functional Structure, Synthesis and Therapeutic Uses


Travis Stokes (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

Human Serum Albumin (HSA) is the most abundant plasma protein. It has been widely used for drug delivery systems and has recently emerged as a versatile carrier for therapeutic agents against diabetes, cancer and infectious diseases. This book provides an overview of the expanding field of preclinical and clinical applications and developments that use albumin as a carrier of drug delivery systems. The authors’ discuss the properties of drug binding sites within the structure of HSA, discuss new possibilities for the therapeutic potential of HSA and analyze recently reported HSA-drug complexes including HSA-antibody conjugates.

Novel investigations on the applications of albumin fusion proteins are discussed as well, with a focus on tumor targeting and intracellular delivery. Other chapters examine the different aspects of albumin glycation and oxidation, the changes in the structure of human serum albumin determined from infrared spectroscopy and a review of CAPIDAN, a special fluorescent dye, which attaches to drug binding sites of human serum albumin.
(Imprint: Nova)




Table of Contents


Chapter One
Potential use of Human Serum Albumin as a Drug Delivery System
(Yu Ishima, Toru Maruyama and Masaki Otagiri, Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, and others)

Chapter Two
Human Serum Albumin (HSA) Drug Delivery System
(Dorota Bartusik, David Aebisher and Boguslaw Tomanek, Southern Polytechnic State University, Department of Biology and Chemistry, Marietta, Georgia, USA, and others)

Chapter Three
Recombinant Human Serum Albumin Fusion Proteins: Novel Applications and Challenges
(Daoyuan Dong, Zhijun Li, Xun Li, Zhiyu Li, Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Department of Chemistry and Biochemistry, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, Pennsylvania, USA, and others)

Chapter Four
Pharmacokinetically Modified Human Serum Albumin Based Therapeutic Design and Development
(Kazuaki Taguchi, Victor Tuan Giam Chuang, Keishi Yamasaki, and Masaki Otagiri, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan, and others)

Chapter Five
Glycative and Oxidative Modification of Human Serum Albumin: Conformational and Functional Changes
(Makoto Anraku, Ulrich Kragh-Hansen, Toru Maruyama and Masaki Otagiri, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan, and others)

Chapter Six
Analysis of the Organic Solvent Effect on the Hydration and Structure of Human Serum Albumin by Infrared Spectroscopy
(Vladimir A. Sirotkin, Kazan Federal University, A.M. Butlerov Institute of Chemistry, Kazan, Russia)

Chapter Seven
CAPIDAN, a Fluorescent Reporter for Detection of Albumin Drug-Binding Site Changes
(G. E. Dobretsov, T. I. Syrejschikova, N. V. Smolina, and M. G. Uzbekov, Research Institute for Physical Chemical Medicine, Moscow, Russia, and others)
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