Human Health is a Matter of Timing: The Impact of Circadian Medicine on Disease and Health


Sumeyya Deniz Aybek, PhD – Ordu University, Faculty of Medicine, Department of Medical Biology, Ordu, Turkey
Gonca Gulbay, PhD – Ordu University, Faculty of Medicine, Department of Medical Biology, Ordu, Turkey
Mucahit Secme, PhD – Ordu University, Faculty of Medicine, Department of Medical Biology, Ordu, Turkey

Series: Sleep – Physiology, Functions, Dreaming and Disorders
BISAC: MED008000; MED022000

Life on Earth is adapted to our planet’s 24-hour rotation and orbital revolution around the sun. The circadian clock is an organism’s natural timing device. It establishes a link between the organism and its external environment to drive rhythms in feeding, activity and rest, body temperature, and hormones, and it ranges from the level of the cell to the whole organism and from bacteria to mammals. The biological clock has emerged as a potent regulator of human physiology, and it orchestrates cellular trafficking to achieve whole-body metabolic synchronization. A temporary mismatch between this internal biological clock and our external environment could increase the risk for various diseases such as cardiovascular diseases, diabetes, obesity, infertility, neurological disorders, and cancer. This book is comprised of twenty chapters written by experienced and passionate academics and professionals and will be a valuable source of information for scientists and clinicians. Collectively, this book has provided a comprehensive account of our current knowledge about emerging insights into the circadian rhythm in physiology and diseases. It will shed light on clinical and basic research and provide the development of new clinical strategies for therapeutic intervention.

Table of Contents


Chapter 1. Introduction to the Circadian Clock
Mustafa Can Güler

Chapter 2. The Mammalian Circadian Clocks: Clock Genes and Circadian Transcriptional Mechanisms
Gözde Öztan

Chapter 3. Hormonal Rhythm.
Gül Akar and Fatma Şengül

Chapter 4. The Circadian Regulation and DNA Damage
Saime Sezer Sondas

Chapter 5. The Human Circadian Clock: Sleep Homeostasis and Sleep Disorders.
Meryem Pelin and Havva Sert

Chapter 6. The Metabolic Clock: Rhythmicity of Metabolic Processes,  Circadian Disruption, and Diseases.
Duygu Keser

Chapter 7. The Circadian Immune System: Circadian Regulation of Innate Immunity and Adaptive Immunity.
Mehmet Akif Gun

Chapter 8. The Aging Clock.
Dilek Arslan Ateşşahin and Yusuf Muhammed Durna

Chapter 9. The Circadian Rhythm and Light Influence on Skin Health and Disorders
Seyfullah Yücel

Chapter 10. The Circadian Control of the Cardiovascular System and Cardiovascular Diseases
Yasemin Doğan

Chapter 11. The Circadian Clock in Neuroinflammation and Neurogenetic Disorders
Zeynep Birsu Cincin and Soner Sahin

Chapter 12. Dysfunctional Circadian Clock and Mood Disorders
Mehmet Buğrahan Gürcan, Zeynep Nur Demirok and Erdoğdu Akça

Chapter 13. The Connection of Circadian Clock to Gastrointestinal Diseases.
Serdar Tanas

Chapter 14. Pediatric Circadian Clock Disorders
Emre Öztürk

Chapter 15. Impact of Light and Circadian Clock on the Reproductive Health.
Sena Özcan Yıldırım and Merve Kavak Balgetir

Chapter 16. The Retinal Circadian Clock: Retinal Health and Retinal Disorders.
Mahmut Doğan

Chapter 17. Physiopathology of Allergic Diseases and Their Relation to Circadian Rhythm
Gül Şahika Gökdemir

Chapter 18. Roles of Light and the Circadian Rhythm in Response to Viral, Bacterial, and Parasitic Infections
Aydan Çevik Varol

Chapter 19. Roles of Light and the Circadian Rhythm in Cancer Pathogenesis
Ayse Kocak

Chapter 20. Recent Advances in Chronotherapeutic Applications
Ekrem Dutoğlu


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