Horizons in Cancer Research. Volume 84

$250.00

Hiroto S. Watanabe (Editor)

Series: Horizons in Cancer Research
BISAC: MED062000

This volume includes eight chapters that describe recent updates in cancer research. Chapter One highlights the benefits of ancillary/consulting care services within pediatric oncology, including social work, psychology, neuropsychology, expressive therapies, child life, chaplaincy, teachers/school liaisons, rehabilitation therapies, nutrition, and palliative care. Chapter Two discusses various generations of chimeric antigen receptors (CAR) and recent efforts in manufacturing CAR T-cells as a therapy for cancer treatment. Chapter Three explores alternative target pathways for putative therapeutic approaches affecting chronic myeloid leukemia cells. Chapter Four reviews research done on the role of epigenetics in the initiation and progression of thyroid cancer. Chapter Five summarizes the literature that implicates the underlying molecular mechanisms of paclitaxel resistance and the potential therapeutic targets to overcome this resistance. Chapter Six deals with the inhibition of autophagy for instigating temozolomide for increasing induction of apoptosis in glioblastoma. Chapter Seven studies the use of vitamin E for leukemic stem cells reprogramming. Finally, Chapter Eight describes new molecular studies for approaches affecting chronic myeloid leukemia cells.

Table of Contents

Preface

Chapter 1. Building and Sustaining a Comprehensive Pediatric Oncology Care Team: The Roles and Integration of Psychosocial and Rehabilitative Team Members
Katherine Price PsyD,1 Amy Downes Westfall, OTD, OTR/L,2 Rev. Connie Beemer, MDiv, BCC,3
Linda H. Casper, MS,4 Daphne Dierkes, ATR, LPC,4 Erin M. Hickey, MD,5,6 Kristin M. Kueper, MS, RD, CSP, LD,7 Tyler Robertson, MA, CCLS,4 and Rebecca H. Foster, PhD1,6
1Department of Psychology, St. Louis Children’s Hospital, St. Louis, MO, USA
2Department of Therapy and Audiology Services, St. Louis Children’s Hospital, St. Louis, MO, USA
3Department of Chaplaincy and Social Work, St. Louis Children’s Hospital, St. Louis, MO, USA
4Department of Child Life Services, St. Louis Children’s Hospital, St. Louis, MO, USA
5Department of Newborn Medicine, St. Louis Children’s Hospital, St. Louis, MO, USA 6Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA
7Department of Nutrition Services, St. Louis Children’s Hospital, St. Louis, MO, USA

Chapter 2. Recent Advances in Manufacturing of Chimeric Antigen Receptor T Cells for Cancer Therapy
Sena Dere1, Alison Greteman1 and Dharmakeerthi Nawarathna1,2
1
Biomedical Engineering program, North Dakota State University, Fargo, ND, USA
2Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND, USA

Chapter 3. Alterations of Epigenetic Gene Expression Regulation in Thyroid Cancerogenesis
Branislav Rovcanin, MD, PhD
University of Belgrade, Faculty of Medicine, University Clinical Center of Serbia, Clinic for Endocrine Surgery, Belgrade, Serbia

Chapter 4. Alternative Target Pathways for Putative Therapeutic Approaches Affecting Chronic Myeloid Leukemia Cells
L. P. Shvachko1, S. V. Antonenko1, D. S. Guryanov1, M. P. Zavelevich2, D. F. Gluzman2
and G. D. Telegeev1
1
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine
2RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Chapter 5. Paclitaxel Resistance in Head and Neck Cancer: Underlying Molecular Mechanisms and Potential Therapeutic Targets to Overcome Paclitaxel Resistance
Abdulmelik Aytatli1,2 and Omer Faruk Karatas1,2
1Molecular Biology and Genetics Department, Erzurum Technical University,
Erzurum, Turkey
2High Technology Application and Research Center, Erzurum Technical University, Erzurum, Turkey

Chapter 6. Inhibition of Autophagy for Instigating Temozolomide for Increasing Induction of Apoptosis in Glioblastoma
Evan D. Wilson and Swapan K. Ray
Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA

Chapter 7.  Ectopic Placental-Like Alkaline Phosphatase (PLAP) Reprogramming to Differentiation by Vitamin E Exposure in Leukemic K562 Cells
L. P. Shvachko1, M. P. Zavelevich2, D. F. Gluzman2 and G. D. Telegeev1
1
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine
2RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NASU, Kyiv, Ukraine

Chapter 8. New Molecular Studies for Approaches Affecting Chronic Myeloid Leukemia Cells to Differentiation Pathways
L. P. Shvachko1, M. P. Zavelevich2, D. F. Glusman2 and G. D. Telegeev1
1
Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine
2R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine

Index