Horizons in Cancer Research. Volume 82


Hiroto S. Watanabe (Editor)

Series: Horizons in Cancer Research
BISAC: MED062000
DOI: https://doi.org/10.52305/KWEJ9169

This volume presents some of the latest research surrounding cancer. Chapter One provides a background on the importance of magnesium homeostasis, reviews the pre-clinical and clinical studies using magnesium therapy for cisplatin-induced acute kidney injury, and proposes future investigations to improve the translatability of these results to cancer treatment. Chapter Two discusses various liquid biomarkers of ovarian cancer such as exosomes, cell free DNA, miRNAs, circulating tumor cells, secretory proteins and autoantibodies and their subsequent detection via various nanobiosensors. Chapter Three explores the potential of mouse xenograft models for elucidating resistance mechanisms to cancer therapeutics. Chapter Four summarizes melatonin’s beneficial effects in ovarian follicular cells and oocytes, followed by a comprehensive description of melatonin as an alternative treatment for ovarian cancer. Chapter Five deals with the gene signatures potentially implicated in the development of endometrial cancer. Lastly, Chapter Six updates current understanding of the role of glucocorticoid receptor-mediated actions in triple-negative breast cancer.

Table of Contents


Chapter 1. Magnesium Therapy in Cisplatin-Treated Cancers: Renoprotection and the Beneficial Effects of Magnesium Homeostasis on Tumor Cell Biology
Swati Madankumar, Gopal Kumar and Christine N. Metz – The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, US, et al.)

Chapter 2. Nanotechnology Based Diagnostic Methods of Ovarian Cancer Detection Using Noninvasive Biomarkers
(Smriti Singh, Bankuru Navyatha and Seema Nara – Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, U.P., India)

Chapter 3. Mouse Xenograft Models for Elucidating Resistance Mechanisms to Cancer Therapeutics
(Wenfa Ng – Department of Biomedical Engineering, National University of Singapore)

Chapter 4. Melatonin as a Potential Natural Agent Protecting the Ovaries and Attenuating Ovarian Cancer Aggressiveness
(Luiz Gustavo de Almeida Chuffa, Henrique Spaulonci Silveira, Roberta Carvalho Cesário, Letícia Barbosa Gaiotte, Maira Smaniotto Cucielo, Renan Aparecido Vígaro and Vinícius Augusto Simão – Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University, Botucatu, SP, Brazil)

Chapter 5. Uterine Transcriptome during Aging Reveals Gene Signature Potentially Implicated in the Development of Endometrial Cancer
(Luiz Gustavo de Almeida Chuffa, Debora Aparecida Pires de Campos Zuccari, Marcelo Martinez3, Francisco Eduardo Martinez and Vinicius Augusto Simão – Department of Structural and Functional Biology, UNESP – São Paulo State University, Institute of Biosciences, Botucatu, São Paulo, Brazil, et al.)

Chapter 6. Emerging Role of Glucocorticoid Receptor in Triple Negative Breast Cancer
(Raj Kumar – Department of Biomedical Sciences, College of Medicine, University of Houston, Houston, TX, US)


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