Horizons in Cancer Research. Volume 80


Hiroto S. Watanabe (Editor)

Series: Horizons in Cancer Research


This edited volume presents six chapters detailing recent progress in the field of cancer research. Chapter One discusses the current information available regarding chemotherapy-induced peripheral neuropathy, including definition, prevalence, pathophysiology at nerve fibers, risk factors, physiology of specific antineoplastic agents on the peripheral nervous system, signs and symptoms, diagnostic criteria, and treatment methods. Chapter Two aims to substantiate the value of tumor-associated circulating and tissue miRNAs for assessing both the aggressiveness of the malignant process course and the sensitivity to neoadjuvant polychemotherapy (NPCT) in breast cancer patients of various molecular subtypes. Chapter Three summarizes the current role of nuclear factor kappa B (NF-κB) in cell aging, its dual functions in the balance of proliferation and apoptosis pathways and the current knowledge of not only the physiological but also the pathophysiological missions of NF-κB and its potential role as a target of therapeutic intervention against breast cancer. Chapter Four deals with 5-aminolevulinic acid radiodynamic therapy for treatment of high-grade gliomas. Chapter Five presents a literature review to identify the possible role of sex hormone receptors in gender variation and sexual dimorphism in the genesis and progression of urothelial bladder cancer (UBC). Lastly, Chapter Six discusses the risk factors, diagnostic modalities, and outcomes of cholangiocarcinoma (CCA), the second most common primary hepatobiliary malignancy.

Table of Contents


Chapter 1. Chemotherapy-Induced Peripheral Neuropathy: From Diagnosis to Treatment
(Mary Jesse – Board-Certified Clinical Specialist in Orthopedic Physical Therapy, Board-Certified Clinical Specialist in Oncologic Physical Therapy, Decatur Memorial Hospital, Decatur, Illinois, US)

Chapter 2. The Expression Profile of Tissue and Circulating miRNAs for Optimization of Neoadjuvant Therapy of Breast Cancer Patients
(Vasyl F. Chekhun, Nataliia Yu. Lukianova, Tetiana V. Borikun, Volodymyr M. Bazas, Tetiana V. Yalovenko, Iryna V. Shepelenko, Taras V. Zadvornyi, Oleksandr M. Kliusov and Yurii V. Dumanskii – Department of Tumor Process Monitoring and Therapy Design, Laboratory of Drug Resistance Mechanisms, RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine, et al.)

Chapter 3. Current Mechanisms and Strategies for the Therapeutic Manipulation of NF-κB in Cell Aging and Breast Cancer
(Gonul Kanigur-Sultuybek, Tugba Soydas, Elif Yaprak Sarac and Büsra Yaprak Bayrak – Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul Turkey, et al.)

Chapter 4. 5-Aminolevulinic Acid Radiodynamic Therapy for Treatment of High-Grade Gliomas
(Alex P. Michael, Nathan Nordmann, Mohamed S. Zaghloul and Richard E. Kast – Department of Neurosurgery, Weill Cornell School of Medicine, New York, NY, US, et al.)

Chapter 5. The Emerging Role of Sex Steroid Receptors in Urothelial Bladder Cancer
(H. Krishna Moorthy, P. Venugopal and G. G. Laxman Prabhu – Department of Urology, Lourdes Hospital, Kochi, S. India, et al.)

Chapter 6. Cholangiocarcinoma: Diagnosis, Risk Factors and Outcome
(Mangesh M. Londhe – Department of Pathology, PCMC PGI YCMH, Pune, Affiliated to Maharashtra University of Health Sciences, Nashik, Maharashtra, India)


Additional information



Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!