Horizons in Cancer Research. Volume 64


Hiroto S. Watanabe (Editor)

Series: Horizons in Cancer Research
BISAC: MED062000

This book presents original results on the leading edge of cancer research. Chapter One presents an overview of the opportunities and challenges that influence the participation of personalized approach of giving the right drug at the right dose to the right patient. Chapter Two examines malignant mesothelioma. Chapter Three reviews the role of heat-shock proteins and chaperonins in the pathogenesis and progression of cancer. Chapter Four discusses the biosynthesis of LeX family glycosphingolipids and its gene regulation. Chapter Five summarizes how chromosome segregation is accurately controlled and how spindle assembly checkpoint (SAC) monitors this process to maintain segregation fidelity. Chapter Six reviews significant novel findings and the early clinical development of a CD26-targeted therapy for malignant pleural mesothelioma (MPM), and advances that can lead to a more hopeful future for MPM patients. Chapter Seven reviews the pathophysiology and novel treatment strategies in management of peripheral T-Cell lymphoma. Chapter Eight discusses the confirmation behind a role for metformin in cancer therapy and its prospective molecular mechanisms of action. Chapter Nine highlights the role Ganoderma lucidum and its constituents in cancer signaling. Chapter Ten studies the footprint of Ganoderma lucidum in receptor tyrosine kinases. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1. Impact of Personalized Medicine in Cancer
Pushpendra Singh, Alka Rani and Felix Bast (Centre for Biosciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India)

Chapter 2. Malignant Mesothelioma
Anwar M. Alesawi (Uro-oncologist, MIS & Robotic Urologist, Head of Urology Department, King Abdullah Medical Complex, Jeddah, Saudi Arabia)

Chapter 3. The Role of Heat-Shock Proteins and Chaperonins in the Pathogenesis and Progression of Cancer
Gisela I. Mazaira, Alejandra G. Erlejman and Mario D. Galigniana (Instituto de Biología y Medicina Experimental-CONICET. Buenos Aires, Argentina, and others)

Chapter 4. Biosynthesis of Lex Family Glycosphingolipids and its Gene Regulation: XIV. in Apoptotic Breast Carcinoma Cells
Subhash Basu, Ma Rui, Joseph R. Moskal, and Manju Basu (Department of Chemistry and Biochemistry and Cancer Drug Delivery Research Foundation, University of Notre Dame, Notre Dame, IN, USA, and others)

Chapter 5. Chromosome Instability as a Target for Cancer Therapeutics: Challenges of Mitotic Inhibitors
Akihiro Ohashi (Molecular Pharmacology Group Head, Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan)

Chapter 6. CD26-Targeted Therapy: A New Horizon in Malignant Pleural Mesothelioma Management
Kei Ohnuma, Ryo Hatano, Hiroto Yamazaki, Yutaro Kaneko, Nam H. Dang, and Chikao Morimoto (Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan, and others)

Chapter 7. Pathophysiology and Novel Treatment Strategies in Management of Peripheral T-Cell Lymphoma, Not Otherwise Specified
Susmitha Apuri, Ling Zhang and Lubomir Sokol (Hematology/Oncology Fellowship Program, H Lee Moffitt Cancer Center and Research Institute/University of South Florida, Tampa, Florida, USA, and others)

Chapter 8. Influence of Insulin and Metformin on Prostate Cancer
Pushpendra Singh, Felix Bast, Shashank Kumar, and Khem Chand Saini (Centre for Biosciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India, and others)

Chapter 9. Ganoderma lucidum: Taxonomy, Cultivation, and Medicinal Value
Balraj Singh Gill, Navgeet and Sanjeev Kumar (Centre for Biosciences, Central University of Punjab, Bathinda, Punjab, India)

Chapter 10. Footprint of Ganoderma lucidum in Receptor Tyrosine Kinases
Balraj Singh Gill, Navgeet, Arvind Negi, Arindam Adhikary, Rashmi Saini, Renu Yadav, Sanjeev Kumar (Centre for Biosciences, Central University of Punjab, Bathinda, Punjab, India, and others)


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