Horizons in Cancer Research. Volume 61


Hiroto S. Watanabe

Series: Horizons in Cancer Research
BISAC: MED062000

This book presents original results on the leading edge of cancer research. Chapter One explains unanswered questions of contemporary oncology from the standpoint of karyogamic theory of carcinogenesis.

Chapter Two focuses on the molecular players of the human papillomaviruses (HPVs) infection leading to chronic inflammation and cancer.

Chapter Three describes Multiple Myeloma (MM), and Monoclonal Gammopathy of Undetermined Significance (MGUS).

Chapter Four reviews the role of choline metabolites as second messengers in cellular pathways leading to enhanced cell survival, migration, and proliferation to explore the possibility that <i>in-vivo</i> imaging of choline metabolism can be used to obtain readouts of cell signal transduction in cancer.

Chapter Five investigates the possible correlation between anatomic melanoma distribution on the specific back area and lack of sunscreen application.

Chapter Six describes the known molecular mechanisms of epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG) in malignant neuroblastoma that can help find new directions for future research.

Chapter Seven discusses the burdens of childhood cancer survivorship and the consequences of different treatment therapies on the incidence of CVD and explores potential monitoring methods and the need for consistent cardiovascular monitoring of childhood cancer survivors regarding their cardiovascular health.

Finally, Chapter Eight considers a model for implementing recommendations pertaining to Lynch syndrome, and also looks at what is happening in the field now to support Lynch syndrome genetic testing and surveillance, and how a deliberative conference can point the way to changes that need to take place to deliver screening to those at risk.
(Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1
Searching for a Magic Key in Oncology Continues
(G. K. Gogichadze, Tbilisi State Medical University, Department of Microbiology and Immunology, Tbilisi, Georgia)

Chapter 2
Mechanisms of Cancer Formation Under Interplay Between Host Immunity and Human Papillomavirus (HPV) Infection
(Masachika Senba and Naoki Mori, Department of Pathology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan, and others)

Chapter 3
Monoclonal Gammopathies: From MGUS to Multiple Myeloma
(Ana Bela Sarmento-Ribeiro, Catarina Geraldes, Adriana Roque, and José Manuel Nascimento Costa, Oncobiology and Hematology Lab, University Clinic of Haematology and Applied Molecular Biology, Faculty of Medicine, University of Coimbra – Coimbra, Portugal, and others)

Chapter 4
Choline Metabolism and Intracellular Signaling in Cancer
(Sandi A. Kwee, The Queen’s Medical Center, Hamamatsu/Queen’s PET Imaging Center and Cyclotron Laboratory, Honolulu, HI, USA, and others)

Chapter 5
The Correlation between Anatomic Sites of the Melanoma Distribution on the Upper Back Area and Lack of Sunscreen Application
(Borut Poljšak, Martina Oder, Jure Polak, Andrej Starc, Tina Levec and Raja Dahmane, University of Ljubljana, Faculty of Health Sciences, Ljubljana, Slovenia)

Chapter 6
Anti-Cancer Activities of the Green Tea Polyphenols EGC and EGCG in Human Malignant Neuroblastoma
(Mrinmay Chakrabarti and Swapan K. Ray, Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, USA)

Chapter 7
The Effects and Long-term Outlook of Cancer Therapies on Cardiovascular Structure and Function in Childhood Cancer Survivors
(Donald R. Dengel, Kara L. Marlatt, Christiana J. Raymond, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA, and others)

Chapter 8
The Broad End of the Stick: Consensus Conference Policy Development of a Public Health Approach to Lynch Syndrome
(Stephen M. Modell, Sharon L. R. Kardia and Toby Citrin, Department of Health Management and Policy, and others)


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