Horizons in Cancer Research. Volume 60

Hiroto S. Watanabe (Editor)

Series: Horizons in Cancer Research
BISAC: MED062000

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This book presents original results on the leading edge of cancer research. Lipomas are extremely common benign lesions, representing the most common softtissue tumor, with a wide spectrum of clinical presentations and imaging appearances. Several subtypes are described, ranging from lesions entirely composed of mature adipose tissue to tumors intimately associated with nonadipose tissue, to those composed of brown fat. Chapter one begins with an overview of the available evidence about the classification, clinical manifestations, diagnostic tests and treatment options of lipomas. The following three chapters examine parosteal lipomas and giant lipomas.

Chapter five studies the first literary description of cavernous angiolipoma of the subcutis in a 75-year-old man, delivering a new lipomatous entity. Chapter six focuses on immune plasticity and susceptibility to cancer from fanconi anemia, which is characterized as a genetic disorder of genomic instability, with main clinical symptoms involving congenital abnormalities, infertility, bone marrow failure and a predisposition to the development of several types of cancer, especially acute myelogenous leukemia (AML) and head and neck carcinomas. Chapter seven discusses radiotherapy for patients with fanconi anemia.

Chapters eight and nine examine the effects of ursolic acid (UA) and flavonol-enriched extract (FL) on the cell cycle behaviour of DU145 human prostate cancer cells in vitro. Chapter ten describes the most current advances made in characterizing the role of PLA2 in tumor development and progression, as well as highlight some of our most recent studies involving iPLA2 and cancer. The remaining chapters discuss the preclinical rationale for targeting human EGFR and recent clinical reports of targeted agents in esophageal cancer; study the pharmaceutical properties and drug likeness of anticancer drugs administered for the clinical treatment of lung cancer; and covers the epidemiology, different etiology and pathogenesis of hepatocellular carcinoma.
(Imprint: Nova Biomedical)

Preface
pp. vii-xii

Chapter 1
Lipomas: Classification, Dermatologic Manifestations and Treatment
(Belen Manso Abajo, Jaime Ruiz Tovar Polo, Ignacio Robles Barrena and Manuel Duran Poveda, Rey Juan Carlos's Hospital, Madrid, Spain)
pp. 1-12

Chapter 2
Parosteal Lipomas
(Marco Mazzocchi, Luca A. Dessy, Silvia Di Ronza, Diego Ribuffo, and Nicolò Scuderi, Department of Plastic and Reconstructive Surgery, University of Perugia, Perugia, Italy, and others)
pp. 13-22

Chapter 3
Giant Lipomas
(Marco Mazzocchi, Luca A. Dessy, Silvia Di Ronza, and Nicolò Scuderi, Department of Plastic and Reconstructive Surgery, University of Perugia, Perugia, Italy, and others)
pp. 23-30

Chapter 4
Multiple Location Giant Liposarcoma - Case Report
(Molnar Călin, Vizitiu Alexandru, Russu Cristian, Tudor Adrian, Butiurca Vlad Olimpiu, Milutin Doina and Molnar Varlam Claudiu, Surgical Clinic No. I, Clinical Emergency County Hospital Tirgu Mures,
University of Medicine and Pharmacy Tirgu Mures, Romania, and others)
pp. 31-38

Chapter 5
A New Lipomatous Entity: The Cavernous Angiolipoma of the Subcutis
(Luca Roncati, Teresa Pusiol, Francesco Piscioli, Giuseppe Barbolini and Antonio Maiorana, Department of Diagnostic and Clinical Medicine and of Public Health, Section of Pathology, University of Modena and Reggio Emilia, Modena (MO), Italy, and others)
pp. 39-44

Chapter 6
Fanconi Anemia: Immune Plasticity and Susceptibility to Cancer
(G. A. Justo and V. M. Rumjanek, Biochemistry Department/IBRAG, State University of Rio de Janeiro, Brazil, and others)
pp. 45-62

Chapter 7
Radiotherapy for the Patient with Fanconi Anemia: A Challenge for the Radiation Oncologist
(Joel S. Greenberger, and Michael W. Epperly, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA)
pp. 63-76

Chapter 8
Ursolic Acid Mediated Inhibition of Human Prostate Cancer Cell Growth in vitro Involves Alterations in Cell Cycle Related Protein Expression
(Joseph Kim, Adriana Catalli, Catherine Neto, and Robert Hurta, Department of Biology, University of Prince Edward Island, Charlottetown, PE., Canada, and others)
pp. 77-88

Chapter 9
Cranberry Flavonols Modulate Cell Cycle-Related Protein Expression in Human Prostate Cancer Cells in vitro
(Joseph Kim, Kunal Patel, Adriana Catalli, Marianna Kulka, Catherine Neto and Robert Hurta, Department of Biology, University of Prince Edward Island,Charlottetown, PE., Canada, and others)
pp. 89-104

Chapter 10
Role of PLA2 in Cancer
(Shannon Kispert, John Marentette, Jordan Powell and Jane McHowat, Department of Pathology, Saint Louis University School of Medicine, St. Louis, Missouri, USA)
pp. 105-122

Chapter 11
EGFR-Related Targeted Therapy in Esophageal Cancer
(Bing Xia, Peng Chen, Shixiu Wu, Department of Radiation Oncology, Hangzhou Cancer Hospital, China)
pp. 123-136
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Chapter 12
Pharmaceutical Properties and Drug Likeness of Anticancer Drugs Administered for the Clinical Treatment of Lung Cancer
(Ronald Bartzatt, University of Nebraska, Durham Science Center, Omaha, Nebraska, USA)
pp. 137-154

Chapter 13
Epidemiology, Pathogenesis and Clinical Presentation of Hepatocellular Carcinoma
(Hyasinta Jaka, Catholic University of Health and allied health sciences-Bugando, Mwanza Tanzania)
pp. 155-160

Index
pp. 161-173

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