Histaminergic and Non-Histaminergic Itch: From Channels to Behavior


Merab G. Tsagareli, PhD, DScHead, Lab of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia
Taylor Follansbee, PhD –  Johns Hopkins University, Baltimore, MD, USA

Series: Dermatology – Laboratory and Clinical Research
BISAC: HEA039130; MED017000; MED093000
DOI: https://doi.org/10.52305/UCLY2326

Itch (pruritus) is an unpleasant skin sensation that compels a person to scratch the affected area. The pathological consequences of itching affect the quality of life just as much as pain. Chronic pruritus conditions such as atopic dermatitis, allergic contact dermatitis, or psoriasis pose a significant socioeconomic burden. This book provides an original account of behavioral, cellular, and molecular aspects of itch in experimental rodents and human subjects. It concentrates on the role of different cellular membrane ion channels functioning in itch states and spinal and cortical pathways which mediate the neural cascade of itch-signaling. The book shows that ion channels are promising targets for developing a new group of antipruritic drugs at the periphery and central levels for therapeutic intervention.

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Table of Contents


Chapter 1. Allodynia and Hyperalgesia in Pruritus: Involvement of TRP Channels
Merab G. Tsagareli¹ and Earl E. Carstens²
¹Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia
²University of California at Davis, Davis, California, USA

Chapter 2. The Role of Descending Modulation in the Transmission of Itch
Taylor Follansbee¹ and E. Carstens²
¹Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
²Department of Neurobiology, Physiology & Behavior, University of California, Davis, California, USA

Chapter 3. Current Understanding of Itch Neural Networks and Circuitry in the Brain
Darya Pavlenko and Tasuku Akiyam
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA

Chapter 4. Molecules That Channel Stimulus into Pruritus
Babina Sanjel and Won-Sik Shim
College of Pharmacy, Gachon University, Incheon, Republic of Korea

Chapter 5. Gastrin-Releasing Peptide and Gastrin-Releasing Peptide Receptor Expressing Neurons
Keiko Takanami
Department of Environmental Health, Faculty of Human Life and Environmental Sciences, National Nara Women’s University, Nara, Japan

Chapter 6. Opioids and Itch
Mark Lay, Taylor Follansbee and Xinzhong Dong
Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA

Chapter 7. Microneurography for Assessing Mechanisms of Itch Signaling in Humans
Miriam Düll¹,² and Barbara Namer¹,³,⁴
¹Institute for Physiology and Pathophysiology, University of Erlangen-Nürnberg, Germany
²Department of Medicine 1, Gastroenterology, Pneumology, Endocrinology, University Hospital Erlangen, Germany
³Research Group Neuroscience, Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University, Germany
⁴Department of Physiology, Faculty of Medicine at the RWTH Aachen University, Germany


Editor’s ORCID iD

Merab G. Tsagareli0000-0003-3581-2845

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