Heterotopic Ossification: Basic Science, General Principles, and Clinical Correlates in Orthopedic Surgery


Series: Rheumatism and Musculoskeletal Disorders
BISAC: MED065000

Heterotopic Ossification: Basic Science, General Principles, and Clinical Correlates in Orthopedic Surgery is a comprehensive, informative approach to understanding the basics through the detailed complexities of heterotopic ossification (HO). The chapters in this book are structured into three main sections: (1) general principles of heterotopic ossification; (2) heterotopic ossification in major anatomic joints; and (3) additional topics and specifics of heterotopic ossification. Each individual chapter is a contribution from a leading expert in the respective subtopic of HO. As a cohesive unit, this book provides a complete reference for students, scientists, clinicians and orthopedic surgeons who find interest in HO or encounter it in the course of patient care.
(Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Section I: General Principles of Heterotopic Ossification

Chapter 1
Basic Science & Pathogenesis
(Anthony Reginato, Division of Rheumatology, Warren Alpert Medical School of Brown University, Providence, RI, United States of America)

Chapter 2
Clinical Findings, Diagnostic Methods & Classification
(May Tsao, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada)

Chapter 3
General Options for Treatment and Prophylaxis
(Alberto Busilacchi, Department of Clinical and Molecular Sciences, Universita Politechnica delle Marche, Ancona, Italy)

Section II: Heterotopic Ossification in Major Anatomic Joints

Chapter 4
(Alessandro Aprato, Orthopaedic Department, University of Turin, Turin, Italy)

Chapter 5
(Brett R. Levine, Division of Adult Reconstruction, Department of Orthopedics, Rush University Medical Center, Chicago, IL, United States of America)

Chapter 6
(Joaquin Sanchez-Sotelo, Department of Orthopedics, Mayo Clinic, Mayo College of Medicine, Rochester, MN, United States of America)

Chapter 7
(Dane H Salazar, Division of Orthopaedic Trauma, Department of Orthopaedic Surgery, Saint Louis University School of Medicine, St. Louis, MO, United States of America)

Chapter 8
Foot & Ankle
(Adam Schiff, Department of Orthopaedic Surgery & Rehabilitation, Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States of America)

Section III: Additional Topics & Specifics of Heterotopic Ossification

Chapter 9
Cervical Intervertebral Disc Replacement
(Adam M. Caputo, Orthocarolina Spine Center, Charlotte, NC, United States of America)

Chapter 10
Fibrodysplasia Ossificans Progressiva, Progressive Osseous Heteroplasia & Albright’s Hereditary Osteodystrophy
(Javier Bachiller Corral, Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain)

Chapter 11
Nervous System
(Craig Kemper, Department of Neuro-Oncology, Austin Brain & Spine, Seton Family of Hospitals, Austin, TX, United States of America)

Chapter 12
Animal Models
(Joris Anthonissen, Department of Orthopedics and Trauma Surgery, University Medical Centre, Johannes Gutenberg-University of Mainz, Langenbeckstrabe, Mainz, Germany)

Chapter 13
Combat-Related Heterotopic Ossification
(Benjamin K. Potter, Department of Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD, United States of America)

Chapter 14
Heterotopic Ossification from Seeded Reamings after Intramedullary Reamed Nail Fixation of Long Bone Fractures
(Philip F. Stahel, Department of Orthopedic Surgery, University of Colorado, School of Medicine, Denver Health Medical Center, Denver, CO, United States of America)

Chapter 15
Heterotopic Ossification in Paraplegic Patients: An Author’s Original Perspective
(John Russell Silver, Emeritus Consultant, Stoke Mandeville Hospital, Buckinghamshire, United Kingdom)



“This book is one of the few recognized texts focused on the topic of heterotopic ossification, and presents a complete, yet concise, summary of this common clinical entity. It provides an in-depth look into the condition from the pathophysiology behind its development through its clinical and societal impact using the most up-to-date literature. The book’s systematic approach to the topic makes it a relevant text to persons afflicted with the condition wanting to learn more about their disease, students of the biomedical sciences who are studying its pathophysiology, biomedical scientists who are searching for a better prophylactic or therapeutic modality to prevent or treat this condition, and Orthopedic surgeons and trainees of any subspecialty who may be faced with the task of operative excision. I strongly recommend this book.” – Joshua J. Jacobs, MD, William A. Hark, MD/Susanne G. Swift Professor and Chairman, Department of Orthopedic Surgery, Associate Provost for Research, Rush University Medical Center

“Heterotopic Ossification: Basic Science, General Principles, and Clinical Correlates in Orthopedic Surgery” is an outstanding reference for the orthopedic community on a problem commonly seen in all orthopedic subspecialties and never before so well summarized in a single volume. Encyclopedic in its coverage, this compact volume will fit the needs of any clinician or research scientist with interest in this disease process. A large number of international experts, thoughtfully assembled by Bryan Saltzman M.D., thoroughly review the basic science underlying the pathogenesis of the disease process, as well as the epidemiologic, clinical and classification principles useful in understanding the pathophysiology as well as the principles of treatment.
The process of heterotopic ossification (HO) occurs in all regions of the musculo-skeletal system, but manifests in specific ways based on local anatomy. Therefore a detailed review of the clinical issues on a regional basis is essential. The following chapters are thus regionally based. Comprehensive in their coverage of the clinical aspects of HO, they are also systematic: beginning with a review of pathophysiology, incidence by etiology, risk factors, classification schemes, and clinical manifestations followed by a thorough discussion of treatment indications and techniques. Each chapter is carefully edited, so easily digested, as well as being thoroughly referenced.
The final segment of the text reviews additional interesting aspects of heterotopic ossification ranging from a review of animal models, ossification in the nervous system, and combat-related ossification as well other specific systemic pathologies. Each of these chapters, while unique in their orientation, are equally well written, and comprehensive.
This volume is an excellent guide to understanding, diagnosing and treating this common and frequently vexing disease. I believe there is nothing currently available to compete with it in the educational marketplace. For both experienced clinicians across the entire range of orthopedic surgery sub-specialties, as well as for trainees with a need for comprehensive regional coverage, it is truly a thorough reference. It should be an essential addition to every teaching program library, and would be a welcome volume to the personal collection of all orthopedic clinicians as well as bone scientists with an interest in the clinical aspects of this disease.” – Aaron G. Rosenberg, MD, Professor, Department of Orthopedic Surgery, Rush University Medical Center

As a cohesive unit, this book provides a complete reference for high school or collegiate students, scientists, musculoskeletal/rheumatologic clinicians and orthopedic surgeons who find interest in HO or encounter it in the course of patient care.

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