Hepatotoxicity: Symptoms, Management and Health Implications

Senthilkumar Rajagopal, Ph.D. (Editor)
Department of Zoology, Nizam College, Hyderabad, Andhra pradesh, India; Endocrine Research Facility, Department of Animal Sciences, Rutgers University, NJ, USA

Sengottuvelan Murugan, Ph.D. (Editor)
Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey, US

Series: Hepatology Research and Clinical Developments
BISAC: MED114000

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Over the past few years, epidemiological studies have revealed that there is an increase of life threatening liver diseases worldwide. It becomes increasingly clear that developments in thisfield are moving so rapidly toward the creation of new drugs against these maladies. Numerous research articles and books have been published on various aspects of toxicities, symptoms, managements and health implications of the liver. Consequently, a catalogue of collective information of toxicities, various features of natural products, and remedies for the prevention of toxicities is needed. This book deals with the toxicities in organs like the liver and the role natural products have in the preventing these ailments. It also analyzes trends in the processing of natural products by using nanotechnology and their health implications.

The main purpose of this book is to exhibit relevant, modern information on hepatotoxicity, its symptoms, and treatments presented by internationally recognized experts in the field. Therefore, it is our belief that this book has covered some of the most interesting aspects of research in liver diseases and provides a trustworthy source of current information in this area of research which should prove useful to the scientists interested in this discipline throughout the world. This collection will interest a variety of other scientific disciplines including toxicology, genetics, medicine and pharmacology, as well as drug and food sciences. We hope that our readers will find this volume to be a delightful addition to their personal libraries, laboratories and offices. Additionally, it can be used as a required or recommended text for related courses taught at colleges and universities levels.
(Imprint: Nova Biomedical)

Preface

Alcoholic Hepatotoxicity: Symptoms and Managements
(Senthilkumar Rajagopal, Supraj Raja Sangam, Shubham Singh,
Venkateswara Rao Joginapally, Department of Zoology, Nizam College, Hyderabad, Telangana, India, and other)

Potential Role of Polyphenols on Liver Health and Diseases
(Sengottuvelan Murugan, Department of Animal Sciences, Rutgers University, NJ, USA)

Pathology of Hepatotoxicity
(M. Bhavani and S. Vamshaj Raja, Department of Pathology, Apollo Institute of Medical Sciences and Research, Hyderabad, Telanaga, India, and other)

Hepatoprotective effect of Phloroglucinol from South Indian Marine Macroalgae against Liver Disorders
(S. Gowtham Kumar, R. Karthik, V. Manigandan, R. Sheeba and R. Saravanan, Department of Medical Biotechnology, Faculty of Allied Health Sciences,Chettinad, Academy of Research and Education, Kelambakkam, Tamil Nadu, India)

Disulphides and Liver Health
(RT. Kasinath, Department of Biochemistry, Subbaiah Institute of Medical Sciences, Karnataka, India)

Toxicological Effects of Vitex Negundo Against the Ontogeny of Corcyra Cephalonica
(M. Madhavi, Assistant Professor, Department of Zoology, Nizam College, Osmania University, Hyderabad, Telangana, India)

Safety Risk Assessment of Hepatotoxicity in Early Drug Development Phases
(María José Gómez-Lechón, Laia Tolosa and María Teresa Donato, Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Avda. Fernando Abril Martorell, Valencia, Spain, and other)

Exposure to Toxic Metals: Impact on Liver and Therapeutic Strategies
(Murugavel Ponnusamy, Amarnath Satheesh Marudamuthu, and Reena Sellamuthu, Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China, and others)

Hepatoprotective Role of Dietary Biomolecules
(Narendhirakannan R.T., Ishwarya .M, Deepika R and Evangeline Celsia S, Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamil Nadu, India)

Role of Epigenetic Modifications in Liver Diseases
(Omkaram Gangisetty, Miguel Cabrera, Endocrine Research Facility, Dept. of Animal Sciences, Rutgers University, New Brunswick, NJ, USA)

Hepatotoxicity of Aflatoxin-B1
(Prakash Srinivasan Timiri Shanmugam, and Senthilkumar Rajagopal, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport, LA, USA, and other)

Burden of Bacterial Bio-films on Hepatocytes
(Sabina Fatima and Senthilkumar Rajagopal, Department of Microbiology, Dr. NTR University of Health Sciences, Vijayawada. Andhra Pradesh, India, and other)

Oxidative Stress-mediated Alcoholic Hepatotoxicity: From Pathogenesis to Potential Therapeutics
(Saravanan Rajendrasozhan, Department of Chemistry, Faculty of Science, University of Hail, Hail, Saudi Arabia)

The Crucial Role of Nrf2-ARE Pathway in Defense against Hepatotoxicity
(Sireesh Dornadula, Bhakkiyalakshmi Elango, Ponjayanthi Balashanmugam, Kunka Mohanram Ramkumar, SRM Research Institute, SRM University, Kattankulathur, Tamilnadu, India)

Hepatotoxicity and Drug Delivery by Nano Particles
(Sivakamasundari Pichu, Scientist/Research Associate, Dept of Pathology, Anatomy and Cell biology, Thomas Jefferson University, Philadelphia, USA, and other)

Index

It is our belief that this book has covered some of the interesting aspects of research in liver diseases and provides a trustworthy source of current information in this area of research and proves useful to the scientists interested in this discipline throughout the world. However, it should be of interest to a variety of other scientific disciplines including toxicology, genetics, medicine and pharmacology, Nanoscience and Nanomedicine, drug discovery and delivery and food sciences. We hope that our readers will find this volume to be a delightful addition in their personal libraries, laboratories and offices and also can be used as a required or recommended text for related course taught at colleges and universities levels.

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