Hemorrhagic Shock: Recognition, Pathophysiology and Management



Series: Emergency and Intensive Care Medicine
BISAC: MED026000

In this first version of the book Hemorrhagic Shock: Recognition, Pathophysiology and Management, the entire spectrum of hemorrhage in various pathologic conditions is explored with a particular emphasis on bleeding from injury. World class experts have summarized their benchtop or clinical investigation of severe bleeding and the subsequent host’s response. Furthermore, contemporary content experts have been assembled to relate their own clinical expertise flanked by literature consensus in the subject. Navigation through the different chapters reveals succinct discussions about epidemiology, pathophysiology, bedside assessment and laboratory investigations. In addition, an important part of the content is practical approaches to the management and/or control of difficult hemorrhage sites including the diagnosis, management, adjunct, pharmaceutical and operative options available for the care of these patients. Additionally, separate chapters are presented for exploring areas related to bleeding in unique patients, including maternal-fetal medicine, prehospital and austere environment settings. Finally, the most novel and cutting edge materials, adjuncts and pharmacological agents are discussed as well as a concerted vision of what the future is likely going to bring to the care of these patients. The authorship reflects a multitude of backgrounds and disciplines, all focused on mitigating the impact of hemorrhage and hemorrhagic shock in its multiple facets. Trainees, advanced practice providers, fellows, attending surgeons, traumatologists, anesthesiologists, emergency physicians and intensivists will find valuable information derived from the vast experiences of the authors and their concise presentation of the most current literature in this dynamic field. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents



Chapter 1. Epidemiology of Hemorrhagic Shock
Jennifer M. Gurney, Tuan D. Le, Tyson E. Becker, and Kevin K. Chung, LTC, MC (US Army, Chief Trauma Systems Development, Joint Trauma System, Assistant Director, Burn Center, US Army Institute of Surgical Research, San Antonio, TX, USA, and others)

Chapter 2. Practical Understanding of the Pathophysiology of Hemorrhagic Shock
Nicole J. Krumrei, Rajan Gupta and Vicente H. Gracias (Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA)

Chapter 3. Cellular Effects of Hemorrhagic Shock & Resuscitation
Nicholas C. Duethman, Colton B. Nielson, Michael Moncure, James M. Howard, and John G. Wood (Orthopedic Surgery, Mayo Clinic Orthopedic Residency Program, Rochester, MN, USA, and others)

Chapter 4. The Functional Assessment of Hemostasis
Anna E. Garcia and Carrie Sims (Resident in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA, and others)

Chapter 5. An Initial Approach to the Bleeding Patient
John Davis Yonge, Phillip Kemp Bohan, Christopher Robert Connelly, and Martin Allen Schreiber (Division of Trauma, Critical Care, & Acute Care Surgery, Oregon Health & Sciences University, Portland, OR, USA)

Chapter 6. Physiologic Monitoring of Bleeding
Stefan W. Leichtle and Kenji Inaba (Assistant Professor of Surgery, Virginia Commonwealth University, Division of Acute Care Surgical Services, West Hospital, Richmond, VA, USA, and others)

Chapter 7. Damage Control Resuscitation
Juan C. Duchesne (Section Chief Trauma/Acute Care Surgery, Trauma Intensive Care Unit Medical Director, Professor of Surgery, Tulane School of Medicine, New Orleans, LA, USA)

Chapter 8. Crystalloid and Colloid Resuscitation
Martin J. Mangino, Loren Liebrecht, Valerie Plant, and Ashley Limkemann (Virginia Commonwealth University, Department of Surgery, Richmond, VA, USA)

Chapter 9. Pharmacologic Hemostatic Adjuncts
Anthony J. Lewis and Jason L. Sperry (University of Pittsburgh/UPMC, Pittsburgh, PA, USA)

Chapter 10. Endpoints of Resuscitation
Brian L. Brewer and Stephanie A. Savage (Indiana University School of Medicine, Indianapolis, IN, USA)

Chapter 11. Unique Aspects of Hemorrhage in Trauma
Mitchell J. Cohen and Gregory M. Borst (Denver Health Medical Center and University of Colorado School of Medicine, CO, USA)

Chapter 12. Cavitary Versus Luminal Sources of Bleeding
Lewis J Kaplan and Emily Carter Paulson (Perelman School of Medicine, University of Pennsylvania, PA, USA, and others)

Chapter 13. Surgical Approaches to Active Bleeding in the Abdomen
Mark L. Gestring and Michael F. Rotondo (Department of Surgery, University of Rochester School of Medicine, Rochester, NY, USA)

Chapter 14. Surgical Approaches to Active Bleeding in the Neck and Extremities
David J. Skarupa and Joseph. J. DuBose (Division of Acute Care Surgery, Department of Surgery, University of Florida College of Medicine, Jacksonville, FL, USA, and others)

Chapter 15. Surgical Approaches to Active Bleeding in the Chest
Brian P. Smith and Tejal Sudhirkumar Brahmbhatt (Perelman School of Medicine, University of Pennsylvania, Medical Office Building, Philadelphia, PA, USA, and others)

Chapter 16. Mechanical Hemorrhage Control
Rachel M. Russo, M. Austin Johnson, and Joseph J. Dubose (Department of Surgery, University of California Davis, Sacramento, CA, USA, and others)

Chapter 17. Anticoagulant and Antiplatelet Reversal Strategies
Beatrice Razzo and Lisa R. Kallenbach (The Perelman School of Medicine at the University of Pennsylvania, Abramson Cancer Center, Penn Presbyterian Medical Center, Philadelphia, PA, USA)

Chapter 18. Bleeding in the Austere Environment
Ronald Chang and John B. Holcomb (Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX, USA, and others)

Chapter 19. Clinical Recognition of Unusual Presentations of Hemorrhagic Shock
David A. Hampton and Samuel A. Tisherman (Acute Care Surgery Fellow, Shock Trauma Center of the University of Maryland Medical Center, Baltimore, MD, USA, and others)

Chapter 20. Unique Concepts in the Bleeding Peripartum Patient
Rebecca Feldman Hamm, Eileen Y. Wang and Rebecca Feldman Hamm (Hospital of the University of Pennsylvania, Department of Obstetrics and Gynecology, Philadelphia, PA, USA)

Chapter 21. Operative Anesthesia Implications in the Hemorrhagic Shock Patient
Maxim Novikov, Maureen McCunn, Rodney McKeever, and Venkat Reddy Mangunta (Department of Anesthesia, Geisinger Medical Center, Danville, Pennsylvania, PA, USA, and others)

Chapter 22. The Future of Hemorrhage Control
Jeremy W. Cannon (Division of Trauma and Surgical Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA) and Erin B. Lavik (University of Maryland, Baltimore County, USA)


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