Hemagglutinins: Structures, Functions and Mechanisms

Tzi Bun Ng (Editor)
Prof. of Biochemistry, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, China

Jack Wong (Editor)
The Chinese University of Hong Kong, China

Ryan Tse (Editor)
Vita Green Pharmaceutical (Hong Kong) Ltd., Hong Kong

Tak Fu Tse (Editor)
The University of Hong Kong, Hong Kong

Helen Chan (Editor)
Vita Green Pharmaceutical (Hong Kong) Ltd., Hong Kong
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

Series: Biochemistry Research Trends
BISAC: SCI007000

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Hemagglutinins refers to glycoproteins which bring about agglutination of erythrocytes or hemagglutination. Hemagglutination can be used to identify surface antigens on erythrocytes (with known antibodies) and, hence, the blood type of an individual. Hemagglutinins consist of lectins and antibodies. Lectins (from the Latin legere, “to select”) are non-immune glycoproteins that exhibit reversible binding to specific carbohydrate structures, glycans of glycoproteins, glycolipids and polysaccharides. Lectins own at least one non-catalytic domain, and, in some cases, a few carbohydrate binding domains, which enable them to effect agglutination of erythrocytes and other cells or precipitation of glycoconjugates. Lectins are found in a constellation of organisms and display an array of activities.

Topics discussed in this book encompass algal lectins, plant type 2 ribosome inactivating proteins, edible legume lectins, jacalin, jacalin-related lectin, wheat lectins, rice lectins, banana lectins and potato lectin, immunomodulatory action of plant lectins, piezoelectric assay using the galactose-binding Bauhinia monandra leaf lectin and its antibody as a potent tool for detection of antigen-antibody recognition, assays using hemagglutinins of different origins to investigate their mechanisms of action, lectins from medicinal herbs and medicinal mushrooms, C-type lectins from a diversity of invertebrates and vertebrates, fish lectins and amphibian lectins.
(Imprint: Nova)

Preface

Chapter 1. Assays Involving Hemagglutinins: Use in Studying the Mechanisms of Action of Lectins
(Luana C. B. B. Coelho, Priscila M. S. Silva, Weslley F. Oliveira, Maiara C. Moura, Francis S. Gomes and Maria T. S. Correia, Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil, and others)

Chapter 2. Bauhinia monandra Leaf Lectin (BmoLL) Is Immunogenic: Electrochemical and Piezoelectric Biosensor Recognized Lectin/IgG ANTI-BmoLL Interactions
(ndra R. Souza, Priscila M. S. Silva, Rosa Amália F. Dutra, Nicolaas J. Haver, Sílvio A. O. Ferreira, José Luiz de Lima Filho, Maria Tereza S. Correia and Luana Cassandra Breitenbach B. Coelho, Departamento de Educação, Universidade Federal Rural de Pernambuco, Recife, Brazil, and others)

Chapter 3. A Review on the Immunomodulatory Effects of Plant Lectins
(Leydianne L. S. Patriota, Jéssica S. Brito, Bruno R. Barboza, Patrícia M.G. Paiva, Cristiane M. L. Melo and Thiago H. Napoleão, Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil, and others)

Chapter 4. Algal Hemagglutinins with Anticancer, Immunomodulatory, Antiviral, Anti-Bacterial, Antinociceptive, Anti-Inflammatory and Pro-Healing Activities
(Jack Ho Wong, Tzi Bun Ng, Charlene Cheuk Wing Ng, Chit Tam, Yau Sang Chan, Ryno Naude, Ryan Tse1, Tak Fu Tse, Helen Chan, Ajay Kumar Gautam, Neha Gupta, Dakshita Tanaji Narvekar, Amita Bhadkari, Shubhlukshmi Kumari, Nidhi Srivastav and Sameer Suresh Bhagyawant, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 5. Anticancer and Other Activities of Lectins from Jacalin, Wheat, Rice and Potatoes
(Jack Ho Wong, Tzi Bun Ng, Charlene Cheuk Wing Ng, Chit Tam, Yau Sang Chan, Ryno Naude, Ryan Tse,
Tak Fu Tse and Helen Chan, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 6. Chickpea Lectin: Purification Strategies, Characteristics and Potential Applications
(Ajay Kumar Gautam, Neha Gupta, Dakshita Tanaji Narvekar, Amita Bhadkaria, Shubhlukshmi Kumari, Nidhi Srivastava, Sameer Suresh Bhagyawant, Jack Ho Wong, Tzi Bun Ng, Yau Sang Cha, Chit Tam, Charlene Cheuk Wing Ng, Ryno Naude, Ryan Tse, Tak Fu Tse and Helen Chan, School of Studies in Biotechnology, Jiwaji University, Gwalior, India, and others)

Chapter 7. Hemagglutinins with Anticancer, Immunomodulatory and Antimicrobial Activities from Medicinal Herbs
(Jack Ho Wong, Tzi Bun Ng, Charlene Cheuk Wing Ng, Chit Tam, Yau Sang Chan, Ryno Naude, Ryan Tse1,
Tak Fu Tse and Helen Chan, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 8. Actions of Type II Ribosome Inactivating Proteins with an Emphasis on Anticancer Activity
(Jack Ho Wong, Tzi Bun Ng, Yau Sang Chan, Chit Tam, Charlene Cheuk Wing Ng, Ryno Naude, Ryan Tse, Tak Fu Tse and Helen Chan, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 9. Recent Research on Anticancer, Antimicrobial, Antiparasitic, and Immunoenhancing Activities of Mushroom Hemagglutinins
(Jack Ho Wong, Tzi Bun Ng, Charlene Cheuk Wing Ng, Chit Tam, Yau Sang Chan, Ryno Naude, Ryan Tse, Tak Fu Tse, Helen Chan, Ajay Kumar Gautam, Neha Gupta, Dakshita Tanaji Narvekar, Amita Bhadkari, Shubhlukshmi Kumari, Nidhi Srivastav and Sameer Suresh Bhagyawant, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 10. C Type Lectins in Invertebrates and Vertebrates
(Jack Ho Wong, Tzi Bun Ng, Charlene Cheuk Wing Ng, Chit Tam, Yau Sang Chan, Ryno Naude, Ryan Tse1, Tak Fu Tse and Helen Chan, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 11. Fish Lectins with Anticancer, Antibacterial, Bacterial Cell Agglutinating, Fungal Cell Agglutinating, Immunoenhancing, Antiviral, and Antiparasitic Activities
(Jack Ho Wong, Tzi Bun Ng, Chit Tam, Yau Sang Chan, Charlene Cheuk Wing Ng, Ryan Tse, Tak Fu Tse and Helen Chan, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)

Chapter 12. Anticancer and Other Activities of Amphibian Hemagglutinins
(Jack Ho Wong, Tzi Bun Ng, Yau Sang Chan, Chit Tam, Charlene Cheuk Wing Ng, Ryno Naude, Ryan Tse, Tak Fu Tse and Helen Chan, Vita Green Pharmaceutical [Hong Kong Limited], Genning Partners Company Limited, and Institute of Medical Research, Hong Kong, China, and others)
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