Helicobacter Pylori: Detection Methods, Diseases and Health Implications



Series: Bacteriology Research Developments, Digestive Diseases – Research and Clinical Developments
BISAC: HEA039010

Infection by Helicobacter pylori has for many years been one of the medical conditions most studied not only in the gastroenterological context. This is because, in recent years, H. pylori has also been involved in a number of extra-intestinal diseases. In this book, we have tried to involve the biggest international experts on the subject. Some authors have tried to provide a complete view of the most common and widely used diagnostic methods, both invasive and non-invasive, also explaining the unusual techniques and the most innovative complementary methods not yet used in clinical practice. Other international experts have tried to describe the latest findings on pathogenesis and the various clinical manifestations of infection by H. pylori in the various systems.

One chapter is reserved for H. pylori infection in childhood, an important period especially in transmission of the infection, explaining the various international guidelines for correct diagnosis and treatment.

The authors have also provided the latest evidence regarding the various methods of eradication therapy, with a critical analysis of the reasons that compel some researchers to believe that eradication at all costs is not always correct and useful for humans.
The book also deals with the current and latest knowledge regarding the progress and the difficulties in the development of a vaccine against H. pylori infection, the implementation of which could solve the problem of the difficulty in the eradication linked mainly to the onset of antibiotic-resistance. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents



Non-Invasive Procedures

Chapter 1. Common Techniques: Serological, Stool Antigen, and Urea Breath Tests
(Rosalia Aloe, Chiara Bonaguri, Marco Manfredi, Fabiola Fornaroli, Pierpacifico Gismondi and Gian Luigi de’Angelis, Department of Pathology and Laboratory Medicine, Azienda Ospedaliero-Universitaria di Parma, University Hospital, Parma, Italy, and others)

Chapter 2. Unusual Techniques: Stool and Dental Plaque PCR, and Urinary Antibodies
(Tessa Horemans, Gaëlle Boulet, Peter Delputte, Louis Maes and Paul Cos, Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium)

Invasive Procedures

Chapter 3. Common Techniques: Endoscopy, Histological Examination, and Rapid Urease Test
(Pellegrino Crafa, Marco Manfredi, Elisabetta Manzali, Barbara Bizzarri and Gian Luigi de’Angelis, Pathology Unit, Department of Biomedical, Biotechnological and Transalational Science, Azienda Ospedaliero-Universitaria di Parma, University Hospital, Parma, Italy, and others)

Chapter 4. Unusual Techniques – Identification of <i>H. pylori</i> from Biopsies: Culture, PCR and FISH
(Carina Almeida, Nuno F. Azevedo and Maria João Vieira, IBB, Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, Braga, Portugal, and others)

Chapter 5. New Optical Techniques Helping in Diagnoses
(Noriya Uedo, Hyung-Hun Kim, Rapat Pittayanon and Ryu Ishihara, Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan, and others)


Chapter 6. Epidemiology, Transmission Routes, and Recurrence of Infection
(Marco Manfredi, Valentina Maffini and Gian Luigi de’Angelis, Gastroenterology and Endoscopy Unit, Azienda Ospedaliero-Universitaria di Parma, University Hospital, Parma, Italy, and others)

<i>Helicobacter pylor</i> Infection and Gastrointestinal Diseases – Gastric Pathology

Chapter 7. Epithelial Dysfunction in the Pathogenesis of <i>Helicobacter pylori</i> Infection
(Tamia K. Lapointe and Andre G. Buret, Inflammation Research Network, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada)

Chapter 8. Clinical Aspects and Complications of <i>Helicobacter pylori</i> Infection
(Marino Venerito and Peter Malfertheiner, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany)

<i>Helicobacter pylori</i> Infection and Associated Extra-Gastric Diseases

Chapter 9. Esophageal and Colon Diseases
(Sergei F. Tatishchev and Hanlin L. Wang, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA)

Chapter 10. Biliary and Liver Diseases
(Peng Zhu, Xun Li, Yuming Wang and Liang Qiao, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqing, China, and others)

<i>Helicobacter pylori</i> Infection and Associated Extra-Gastrointestinal Diseases

Chapter 11. Neurological Disorders and <i>Helicobacter pylori</i> Infection
(Georgia Deretzi, Christos Zavos, Stergios A. Polyzos, Evangelia Giartza-Taxidou, Emmanouel Gavalas, Iakovos Tsiptsios, Theocharis Tsironis, Marina Boziki and Jannis Kountouras, Department of Neurology, Multiple Sclerosis Unit, Papageorgiou General Hospital, Thessaloniki, Greece, and others)

Chapter 12. <i>Helicobacter pylori</i> Infection and Autoimmune and Rheumatological Disorders
(Sarfaraz Ahmed Hasni, National Institute of Arthritis, Musculoskeletal and Skin diseases, National Institutes of Health, Bethesda, MD, USA)

Chapter 13. The Impact of <i>Helicobacter pylori </i> Colonization on Peptides Regulating Appetite and Satiety: Ghrelin, Leptin, and Obestatin
(Víctor Rafael Coria Jiménez, Carolina Romo González and Patricia Chico Aldama, Laboratory of Experimental Bacteriology, National Institute of Pediatrics, Mexico City, Mexico)

Chapter 14. Role of <i>Helicobacter pylori</i> Infection in Hematological Disorders
Wajid Ali, Zhong Wu, Jin Zhou and Bing Peng, Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu, China, and others)

Chapter 15. <i>Helicobacter pylori</i> Infection and Cardiovascular Disorders
(Benjamin Longo-Mbenza, Jacqueline Nsenga Nkondi, Marco Manfredi and Bertrand Tchana, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa, and others)

Chapter 16. <i>Helicobacter pylori </i> and Respiratory Tract Diseases
(Qiang Wang, Chaoran Yu, Gian Luigi de’Angelis and Vincenzo Di Comite, The Second Clinical Department, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology. Wuhan, HuBei, China, and others)

Chapter 17. <i>Helicobacter pylori</i> Infection and Gynecological and Reproductive System Diseases
(Ghada M. Mansour and Marco Manfredi, Associate Consultant of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt, and others)

Chapter 18. <i>Helicobacter pylori </i> Infection and Skin Diseases
(Zekayi Kutlubay, Ozge Karakus, Burhan Engin, Server Serdaroglu and Yalçin Tüzün, Department of Dermatology, Cerrahpaþa Medical Faculty, Istanbul University, Istanbul, Turkey)

Chapter 19. <i>Helicobacter pylori</i> Infection in Children
(Stefano Pontone, Laura Petrarca and Raffaella Nenna, Department of Surgical Sciences, “Sapienza” University of Rome, Rome, Italy, and others)

Chapter 20. Therapy of <i>Helicobacter pylori</i> Infection: Many Drugs for Which Association?
(Ping-I Hsu and Sung-Shuo Kao, Division of Gastroenterology, Department of Internal Medicine, Kaoshiung Veterans General Hospital and National Yang Ming University, Taiwan)

Chapter 21. The Biosynthesis of Isoprenoid Precursors as a New Target for the Development of Specific Antibiotics for the Treatment of <i>Helicobacter pylori</i>-Associated Diseases
(Jordi Perez-Gil, Joan Miralles, Maria Bergua, Albert Boronat, Jaime Rubio-Martinez and Santiago Imperial, Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain, and others)

Chapter 22. <i>Helicobacter pylori</i> Infection: The Vaccine Development
(Irina V. Pinchuk and Ellen J. Beswick, Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, and others)

Chapter 23. <i>Helicobacter pylori</i> Infection: Eradication or Preservation?
(Sun-Young Lee and Soo-Heon Park, Department of Internal Medicine, Konkuk University School of Medicine and Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea)



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