Health Benefits of Phenolic Antioxidants

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Aman B. Upaganlawar, PhD – Associate Professor, SNJBs SSDJ College of Pharmacy, Chandwad, Maharashta, India
Vipin V. Dhote, PhD – Professor and Principal, VNS Group of Institutions, Bhopal, Madhya Pradesh, India
M. K. Mohan Maruga Raja, PhD – Associate Professor, Department of Pharmacognosy & Physiochemistry, Parul Institute of Pharmacy & Research, Parul University, Gujarat, India

Series: Natural Products and Therapeutics
BISAC: REF000000; REF020000
DOI: https://doi.org/10.52305/TYAS3020

Free radicals are continuously produced in cells as a part of normal cellular function. However, excess generation of free radicals plays a critical role in the pathophysiology of many disease conditions, especially cancer, atherosclerosis, Alzheimer’s disease, etc. Oxidation is a major chemical process that produces free radicals and initiates chain reactions that cause cellular damage. Compounds that inhibit oxidation are called antioxidants; phenols are known to possess excellent antioxidant properties. Phenolic compounds are abundant in plants in a wide variety of chemical structures. Natural phenolic compounds include phenolic acids and ester derivatives, flavonoids and benzopyran derivatives, quinones, tannins, lignins, lignans, stilbenes, essential oils, chalcones, etc. Nutraceuticals, in the name of dietary supplements and functional foods, are being consumed as prophylactics for the prevention of many diseases throughout the world. Most of these products are polyphenols; hence, this book provides an insight on therapeutic potentials of natural and synthetic polyphenols, emphasizing their pharmacology.

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Table of Contents

Preface

Chapter 1. Natural and Synthetic Sources of Phenolic Antioxidants
Agilandeswari Devarajan1, Bhagya V. Rao2 and Tisa Francis3
1Director, Research and Development, Synapses AI India Private Limited, Indore, Madhya Pradesh, India
2Associate Professor, Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research (Deemed University), Bengaluru, Karnataka, India
3Assistant Professor, Department of Pharmaceutical Chemistry, Acharya and BM Reddy College of Pharmacy, Bengaluru, Karnataka, India

Chapter 2. Prevention is Better than Cure: Phenolic Antioxidants
Antara Choudhury
Department of Pharmacognosy & Phytochemistry, IKON Pharmacy College, Bheemanahalli, Bengaluru, Karnataka, India

Chapter 3. Oxidative Stress and Pharmacology of Phenolic Antioxidants
Khan Dureshahwar, Naiknaware Raman B., Hemant D. Une and Mohammed Mubashir
Department of Pharmacology, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, Maharashtra, India

Chapter 4. Health Implications of Phenolic Antioxidants from Berries and Citrus Species
Stella Amarachi Ihim1, Thecla Okeahunwa Ayoka2, Njideka Ifeoma Ani3, Joseph Akor2, Abdullahi Alausa4 and Amarachukwu Vivian Arazu2
1
Department of Science Laboratory Technology (Pharmacology Unit), Faculty of Physical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
2Department of Science Laboratory Technology (Biochemistry Unit), Faculty of Physical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
3Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Enugu State, Nigeria
4Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

Chapter 5. Berries as Antioxidant Rich Superfoods
Tanvi R. Dodiya, Disha P. Prajapati and Jaya J. Patel
Parul Institute of Pharmacy and Research, Parul University, Waghodia, Vadodara, Gujarat, India

Chapter 6. Potential Health Benefits of Green Tea Polyphenols
Akshay M. Baheti1, Anil T. Pawar1, Aman Upganlawar2 and Amol A. Tagalpallewar1
1
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Kothrud, Pune, India
2SNJBs SSDJ College of Pharmacy, Chandwad, Nashik, India

Chapter 7. Immunomodulatory Effects of Plant-Based Rasayana with Phenolic Antioxidants
Aditya Ganeshpurkar1 and Ajay Saluja2
1
Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, India
2Krishna School of Pharmacy and Research, K. P. Global University, Vadodara, Gujarat, India

Chapter 8. Therapeutic Role of Phenolic Antioxidants in Herbal Medicine
John Onyebuchi Ogbodo1, Chinazom Precious Agbo2, Adaeze Chidiebere Echezona2, Tobechukwu Christian Ezike3, Stephen Chijioke Emencheta4, Oluebube Chisom Onyia2, Tochukwu Chisom Iguh5 and Stella Amarachi Ihim6
1
Department of Science Laboratory Technology, University of Nigeria, Nsukka, Nigeria
2Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria
3Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
4Department of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka, Nigeria
5Department of Plant Science and Biotechnology, University of Nigeria, Nsukka, Nigeria
6Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria

Chapter 9. Health Benefits of Polyphenols of Triphala
Akshay M. Baheti, Rohini R. Pujari, Aman Upaganlawar, Amol A. Tagalpallewar,and Anil T. Pawar
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Kothrud, Pune, India
Department of Pharmacology, SNJBs SSDJ College of Pharmacy, Chandwad, Nashik

Chapter 10. Potential Polyphenol Alleviating Arthritis: Quercetin on Dysbiosis
Avinash Singh Mandloi1, Danish Khan1, Divya Singh2, Prashant Wagadare1, Vipin Dhote1 and Manisha Kawadkar1
1
Faculty of Pharmacy, VNS Group of Institutions, Neelbud, Bhopal, MP, India
2Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj, UP, India

Chapter 11. Oxidative Stress, Cancer, and Phenolic Antioxidants
S.Poonguzhali1, K. B. Liew2 and K.Anandarajagopal3
1
Taylor’s University Lakeside Campus, Jalan Taylors, Subang Jaya, Selangor, Malaysia.
2University of Cyberjaya, Persiaran Bestari, Cyberjaya, Selangor, Malaysia
3School of Pharmacy, KPJ Healthcare University College, Nilai, Negeri Sembilan, Malaysia

Chapter 12. Health Benefits of Phenolic Antioxidants as Antimicrobial Agents
Sudha Vengurlekar1, Rajesh Sharma2 and Subhash C. Chaturvedi1
1
Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh, India
2School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore- Madhya Pradesh, India

Chapter 13. Neuroprotective Potential of Hydroxybenzoic Derivatives of Phenolic Acids
Shubhangi H. Pawar1, Aman B. Upaganlawar2 and Chandrashekhar D. Upasani2
1
Department of Pharmacology, MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra, India
2Department of Pharmacology, SNJB’s ShrimanSureshdada Jain College of Pharmacy, Chandwad,
Nashik, Maharashtra, India

Chapter 14. Role of Phenolic Antioxidants in the Management of Cardiovascular Diseases
Kuntal Das
Department of Pharmacognosy and Phytochemistry, Krupanidhi College of Pharmacy, Carmelaram Post, VarthurHobli, Bengaluru, India

Chapter 15. Neuroprotective Potentials of Polyphenols: Cumulative Evidence of Pre-Clinical and Clinical Studies
Devang Sheth1, Ketan Shah2, Chirag Patel1 and Sandip Patel1
1
Department of Pharmacology, L.M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, India
2Department of Pharmaceutical Quality Assurance, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India

Chapter 16. Protective Effect of Phenolic Antioxidants in Neuronal Cell Damage against Oxidative Stress
Shyam W. Rangari1, Ruchi R. Khobragade2, Nitu L. Wankhede1, Rashmi V. Trivedi1, Vaibhav S. Marde3, Mohit D. Umare1, Milind J. Umekar1, Sanjaykumar B. Bari4 and Mayur B. Kale1
1Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
2Anurag College of Pharmacy, Warthi, Bhandara, Maharashtra, India
3Indian Institute of Technology, Hyderabad, India
4H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India

Chapter 17. Phenolic Antioxidants as Therapeutic Agents in Major Neurodegenerative Disorders
Pranali A. Chandurkar1, Nitu L. Wankhede1, Vaibhav S. Marde2, Brijesh G. Taksande1, Manish M. Aglawe1, Mohit D. Umare1, Komal K. Bajaj1, Milind J. Umekar1 and Mayur B. Kale1
1Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
2Indian Institute of Technology, Hyderabad, India

Chapter 18. Anti-Aging Property of Natural Phenolic Antioxidants
Trupti A. Banarase1, Nitu L. Wankhede1, Brijesh G. Taksande1, Manish M. Aglawe1, Vaibhav S. Marde2, Mohit D. Umare1, Komal K. Bajaj1, Milind J. Umekar1 and Mayur B. Kale1
1Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
2Indian Institute of Technology, Hyderabad, India

Chapter 19. Antioxidant Potential of Spices and Herbs: A Mechanistic Overview
Kshitij B. Mankar1, Amit R. Shahu1, Pranali A. Chandurkar1, Shyam W. Rangari1, Nitu L. Wankhede1, Brijesh G. Taksande1, Vaibhav S. Marde2, Komal K. Bajaj1, Milind J. Umekar1 and Mayur B. Kale1
1Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
2Indian Institute of Technology, Hyderabad, India

Index