Healing the Mind – Alzheimer’s Disease – Thinking Patents (1983-2007)

Michael J. Dochniak
Coralville, IA, USA

Series: Neuroscience Research Progress
BISAC: MED057000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The brain is a masterpiece that defines your uniqueness. As you age, though, your brain may be susceptible to a terrible disease. Alzheimer’s disease is the most common cause of dementia among older adults. It is considered an irreversible, progressive brain disorder that slowly erases memories and thinking, and eventually eliminates the ability to carry out the simplest of tasks. Alzheimer’s disease may rank third, just behind heart disease and cancer, as the leading cause of death for elderly people. Medical science continues to make progress in the search for therapeutic interventions and a cure. Since 1983, hundreds of Alzheimer’s-related patents have been granted by the United States Patent and Trademark Office in an effort to eradicate this deadly disease. To better understand these inventions, Michael J. Dochniak has written this book to provide an easy-to-read, brief summary of such patents. Within the summaries are inventor profiles and news articles that are insightful and relevant. Impactful inventors include a Nobel laureate, a soldier and an ex-convict. Pioneering inventors include George Glenner, Barbara Cordell, Birinder Boveja, Joseph Buxbaum, Dale Schenk and Vivian Hook. At the beginning of several chapters, you will experience a personal story about Alzheimer’s disease. Most importantly, the book this novel is about keeping your brain healthy as you age. (Imprint: Nova Biomedical)

Preface

Acknowledgement

About the Author

Introduction

Chapter 1. Alzheimer's-related Patents

Chapter 2. Years 1983-1991

Chapter 3. Years 1992-1995

Chapter 4. Years 1996-1997

Chapter 5. Year-1998

Chapter 6. Year-1999

Chapter 7. Year-2000

Chapter 8. Year-2001

Chapter 9. Year-2002

Chapter 10. Years 2003-2004

Chapter 11. Year-2005

Chapter 12. Year-2006

Chapter 13. Year-2007

Patent Glossary

About the Author

Index

Chapter 1

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Chapter 2

[1] Alzheimer’s Association. “Lisa’s Story” Accessed January 25, 2017. http://www.alz.
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[2] Google Patents. “4,419,365” Accessed January 25, 2017. https://patents.google.com/
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93019/Wanda-Hale/.

Chapter 3

[1] Alzheimer’s Association. “Denis’ Story” Accessed January 27, 2017. http://www.alz.
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[2] Google Patents. “5,109,868” Accessed January 27, 2017. https://patents.google.com/
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[3] LinkedIn. “Kim Jobst” Accessed January 27, 2017. https://www.linkedin.com/
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[4] Medscape. 2016. “Alzheimer’s Disease Imaging” Last updated March 15, 2016. Accessed January 27, 2017. http://emedicine.medscape.com/article/336281-overview#a2.
[5] Google Patents. “5,137,873” Accessed January 27, 2017. https://patents.google.com/
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[6] Glenn Foundation. “Bruce A. Yankner” Accessed January 27, 2017. http://www.hms.
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Chapter 4

[1] Alzheimer’s Association. “Muffet’s Story” Accessed January 28, 2017. http://www.alz.org/living_with_alzheimers_15512.asp.
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[3] Neurology. “Laurace E. Townsend” Accessed January 28, 2017. http://bulletins.wayne.
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[16] Masahiro Kawahara and Midori Kato-Negishi. 2011. “Link between Aluminum and the Pathogenesis of Alzheimer’s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses” International Journal of Alzheimer’s Disease 2011: 276-393. doi: 10.4061/2011/276393.
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Chapter 5

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Chapter 6

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Chapter 7

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Chapter 8

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edu.au/user/5232.

Chapter 9

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Journal/EditorialBoard/16.

Chapter 10

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[53] Bloomberg. “Robert L. Heinrikson Ph.D.” Accessed February 2, 2017. http://www.
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[54] Google Patents. “6,703,212” Accessed February 2, 2017. https://patents.google.com/
patent/US6703212B1/en.
[55] Prabook. “Agnes Katalin Janoshazi” Accessed February 2, 2017. http://prabook.com/
web/person-view.html?profileId=158666.
[56] Google Patents. “6,710,226” Accessed February 2, 2017. https://patents.google.com/
patent/US6710226B1/en.
[57] Bloomberg. 2016. “Dale B. Schenk, Prothena Corp. Co-Founder and CEO, Dies at 59” Accessed February 2, 2017. https://www.bloomberg.com/news/articles/2016-09-30/dale-b-schenk-prothena-corp-co-founder-and-ceo-dies-at-59
[58] Google Patents. “6,717,031” Accessed. February 2, 2017. https://patents.google.com/
patent/US6717031B2/en.
[59] LinkedIn. “Russell Rydel” Accessed February 2, 2017. https://www.linkedin.com/in/
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[60] Google Patents. “6,737,420” Accessed February 2, 2017. https://patents.google.com/
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[61] LinkedIn. “Roy K. Hom, Ph.D.” Accessed February 2, 2017. https://www.linkedin.
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[62] Google Patents. “6,750,227” Accessed February 2, 2017. https://patents.google.com/
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[63] Google Patents. “6,753,782” Accessed February 2, 2017. https://patents.google.com/
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[66] Google Patents. “6,770,797” Accessed February 2, 2017. https://patents.google.com/
patent/US6770797B2/en.
[67] Bloomberg. “Jack R. Wands M.D.” Accessed February 2, 2017. http://www.
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[72] Google Patents. “6,811,988” Accessed February 2, 2017. https://patents.google.com/
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[73] Noble Research. “Dr. Ramda M. Mostafa” Accessed February 2, 2017. http://
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[74] Wikipedia. “Sarsasapogenin” Last updated November 22, 2016. Accessed February 2, 2017. https://en.wikipedia.org/wiki/Sarsasapogenin.
[75] Google Patents. “6,812,213” Accessed February 2, 2017. https://patents.google.com/
patent/US6812213B2/en.
[76] LinkedIn. “Phil Gunning” Accessed February 2, 2017. https://www.linkedin.com/in/
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[78] Google Patents. “6,821,504” Accessed February 2, 2017. https://patents.google.com/
patent/US6821504B2/en.
[79] NYU School of Medicine. “Daniel Turnbull” Accessed February 2, 2017. http://www.med.nyu.edu/biosketch/turnbd01.
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[81] Google Patents. “6,825,229” Accessed February 2, 2017. https://patents.google.com/
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[83] JAD. 2015. “Severe Alzheimer's Patient Responds to Bryostatin Treatment” Accessed February 2, 2017. http://www.j-alz.com/content/severe-alzheimers-patient-responds-bryostatin-treatment.
[84] Google Patents. “6,825,329” Accessed February 2, 2017. https://patents.google.com/
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[85] LinkedIn. “Bertram Weiss” Accessed February 2, 2017. https://www.linkedin.com/in/
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[86] Google Patents. “6,835,750” Accessed February 2, 2017. https://patents.google.com/
patent/US6835750B1/en.
[87] Sorbet. “Dr. Samuel Henderson” Accessed February 2, 2017. http://sorbetsocal.com/
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2003.11.028. http://www.medical-hypotheses.com/article/S0306-9877(04)00016-7/abstract.

Chapter 11

[1] Alzheimer’s Association. “Amy’s Story” Accessed February 3, 2017. http://www.alz.org/living_with_alzheimers_10300.asp.
[2] Google Patents. “6,838,592” Accessed February 3, 2017. https://patents.google.com/
patent/US6838592B1/en.
[3] Alzforum. 2009. “Anne Cataldo, 57, Autophagy Researcher Known for Generous Collegiality” Accessed February 3, 2017. http://www.alzforum.org/news/community-news/anne-cataldo-57-autophagy-researcher-known-generous-collegiality.
[4] Google Patents. “6,844,148” Accessed February 3, 2017. https://patents.google.com/
patent/US6844148B1/en.
[5] Cleveland Clinic – Department of Neurosciences. “Riqiang Yan, Ph.D. “Accessed February 3, 2017. https://www.lerner.ccf.org/neurosci/yan/.
[6] Google Patents. “6,846,813” Accessed February 3, 2017. https://patents.google.com/
patent/US6846813B2/en.
[7] David Geffen School of Medicine. “Barbara Jagodzinska, Ph.D.” Accessed
February 3, 2017. http://www.eastonad.ucla.edu/research/drug-discovery-translational-laboratory/item/jagodzinska-barbara-phd.
[8] Google Patents. “6,849,249” Accessed February 3, 2017. https://patents.google.com/
patent/US6849249B2/en.
[9] BU Alzheimer’s Research Center. “Lee E. Goldstein” Accessed February 3, 2017. https://www.bu.edu/alzresearch/about-us/team/faculty/goldstein/.
[10] Hartung, Paul. 2015. “Neurology/Alzheimer’s: Laser-based eye test for early detection of Alzheimer’s” BioOptics World. Accessed February 3, 2017. http://www.
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[11] Google Patents. “6,864,062” Accessed February 3, 2017. https://patents.google.com/
patent/US6864062B2/en.
[12] Wikipedia. “Peter Davies (scientist)” Last updated December 1, 2016. Accessed February 3, 2017. https://en.wikipedia.org/wiki/Peter_Davies_(scientist).
[13] Google Patents. “6,864,290” Accessed February 3, 2017. https://patents.google.com/
patent/US6864290B2/en.
[14] LinkedIn. “Robert (Al) Chrusciel” Accessed February 3, 2017. https://www.linkedin.
com/in/robert-al-chrusciel-30a02b20.
[15] Google Patents. “6,867,236” Accessed February 3, 2017. https://patents.google.com/
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[16] Joseph & Kathleen Bryan Alzheimer’s Disease Research Center. “Kathleen Welsh-Bohmer, Ph.D., ABCN. Accessed January 29, 2017. https://adrc.mc.duke.edu/
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[17] Google Patents. “6,869,768” Accessed February 3, 2017. https://patents.google.com/
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[18] Amazon. “David E. Comings” Accessed February 3, 2017. https://www.amazon.com/
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[19] Google Patents. “6,872,381” Accessed February 3, 2017. https://patents.google.com/
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[20] Bloomberg. “Richard Horuk” Accessed February 3, 2017. http://www.bloomberg.
com/research/stocks/private/person.asp?personId=214992387&privcapId=208462792.
[21] Google Patents. “6,890,727” Accessed February 3, 2017. https://patents.google.com/
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[23] Malamut, Melissa. 2016. “A ‘rock star’ Harvard professor just launched a new app for Alzheimer’s patients” Boston.com, Accessed January 29, 2017. https://www.
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[24] Google Patents. “6,891,081” Accessed February 3, 2017. https://patents.google.com/
patent/US6891081B1/en.
[25] University of Tennessee. “David Stern, MD” Accessed February 3, 2017. https://www.uthsc.edu/Medicine/about/administration/davidstern.php.
[26] Nolletti, Loralee. 2002. “Columbia Professor and Pfizer Inc. Sign Research Agreement for Testing Compounds with Possible Links to Alzheimer’s Disease” Columbia
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Accessed February 3, 2017. http://www.columbia.edu/cu/news/02/01/
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[27] Google Patents. “6,913,745” Accessed February 3, 2017. https://patents.google.com/
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[28] Henry, Ben A. 2016. “Alzheimer’s Immunotherapy Pioneer Dies” The Scientist Accessed February 3, 2017. http://www.the-scientist.com/?articles.view/articleNo/
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[29] Google Patents. “6,933,280” Accessed February 3, 2017. https://patents.google.com/
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[30] PharmaIN. “Management” Accessed February 3, 2017. http://pharmain.com/
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[31] Google Patents. “Accessed February 3, 2017. https://patents.google.com/
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[32] The Michael J. Fox Foundation. “Alan D. Snow, PhD” Accessed January 30, 2017. https://www.michaeljfox.org/foundation/researchers.php?id=627.
[33] Google Patents. “6,942,963” Accessed February 3, 2017. https://patents.google.com/
patent/US6942963B1/en.
[34] Wikipedia. “Vernon Ingram” Last updated October 21, 2016. Accessed February 3, 2017. https://en.wikipedia.org/wiki/Vernon_Ingram.
[35] Wikipedia. “Peter St George-Hyslop” Last updated November 5, 2016. Accessed February 3, 2017. https://en.wikipedia.org/wiki/Peter_St_George-Hyslop.
[36] Google Patents. “6,955,896” Accessed February 3, 2017. https://patents.google.com/
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[37] Cambridge Institute for Medical Research. “Peter St George-Hyslop”
Accessed February 3, 2017. http://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/stgeorgehyslop.
[38] Google Patents. “6,960,470” Accessed February 3, 2017. https://patents.google.com/
patent/US6960470B1/en.
[39] Cold Spring Harbor Laboratory. “Roberto Malinow” Accessed February 3, 2017. http://library.cshl.edu/personal-collections/roberto-malinow.
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[41] Google Patents. “6,962,934” Accessed February 3, 2017. https://patents.google.com/
patent/US6962934B2/en.
[42] David Geffen School of Medicine. “Barbara Jagodzinska, Ph.D.” Accessed
February 3, 2017. http://www.eastonad.ucla.edu/research/drug-discovery-translational-laboratory/item/jagodzinska-barbara-phd.
[43] Google Patents. “6,969,709” Accessed February 3, 2017. https://patents.google.com/
patent/US6969709B2/en.
[44] LinkedIn. “Shon Pulley, Ph.D.” Accessed February 3, 2017. https://www.linkedin.com/
in/shonpulley.

Chapter 12

[1] Alzheimer’s Association. “Debbie’s Story” Accessed February 3, 2017. http://www.alz.
org/living_with_alzheimers_13633.asp.
[2] Google Patents. “6,982,264” Accessed February 3, 2017. https://patents.google.com/
patent/US6982264B2/en.
[3] LinkedIn. “John Tucker” Accessed February 3, 2017. https://www.linkedin.com/in/
jatucker.
[4] Google Patents. “6,988,995” Accessed February 3, 2017. https://patents.google.com/
patent/US6988995B2/en.
[5] Bloomberg. “Michael J. Sinai Ph.D.” Accessed February 3, 2017. http://www.bloomberg.com/research/stocks/private/person.asp?personId=29510473&privcapId=22598819&previousCapId=22598819&previousTitle=Heidelberg%20Engineering%20GmbH.
[6] Google Patents. “6,992,081” Accessed February 3, 2017. https://patents.google.com/
patent/US6992081B2/en.
[7] Myelin Repair Foundation. “Our Executive Team” Accessed February 3, 2017. http://www.myelinrepair.org/about/executive_team.shtml.
[8] Google Patents. “7,015,044” Accessed February 3, 2017. https://patents.google.com/
patent/US7015044B2/en.
[9] Washington University School of Medicine St. Louis. “Holtzman Laboratory” Accessed February 3, 2017. https://neuro.wustl.edu/research/research-labs-2/holtzman-laboratory/.
[10] Google Patents. “7,014,854” Accessed February 3, 2017. https://patents.google.com/
patent/US7014854B2/en.
[11] LinkedIn. “Shirley Furesz, PhD, RAC (Canada)” Accessed February 3, 2017. https://www.linkedin.com/in/shirley-furesz-phd-rac-canada-64070014.
[12] Google Patents. “7,074,576” Accessed February 3, 2017. https://patents.google.com/
patent/US7074576B2/en.
[13] Pivotal Therapeutics. “Senior Management” Accessed February 3, 2017. http://www.
pivotaltherapeutics.us/?page_id=9.
[14] Google Patents. “7,034,182” Accessed February 3, 2017. https://patents.google.com/
patent/US7034182B2/en.
[15] Mary S. Easton Center. “John Varghese, Ph.D.” Accessed February 3, 2017. http://www.adc.ucla.edu/about-us/faculty-and-staff/item/john-varghese-phd.
[16] Google Patents. “7,041,473” Accessed February 3, 2017. https://patents.google.com/
patent/US7041473B1/en.
[17] Bloomberg. “Robert L. Heinrikson” Accessed February 3, 2017. http://www.
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[18] Google Patents. “7,041,688” Accessed February 3, 2017. https://patents.google.com/
patent/US7041688B2/en.
[19] LinkedIn. “Alister Campbell” Accessed February 3, 2017. https://www.linkedin.com/
in/alister-campbell-42ab727.
[20] Google Patents. “7,045,616” Accessed February 3, 2017. https://patents.google.com/
patent/US7045616B2/en.
[21] Bloomberg. “Jack R. Wands M.D.” Accessed February 3, 2017. http://www.
bloomberg.com/research/stocks/private/person.asp?personId=32834179&privcapId=962022.
[22] Google Patents. “7,049,078” Accessed February 3, 2017. https://patents.google.com/
patent/US7049078B2/en.
[23] Wikipedia. “Jude Poirer” “Accessed June 28, 2017. https://en.wikipedia.org/
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[24] Google Patents. “7,052,852” Accessed February 3, 2017. https://patents.google.com/
patent/US7052852B1/en.
[25] “USC is at the forefront of Alzheimer’s research” Los Angeles Times April 22, 2016. Accessed February 3, 2017. http://www.latimes.com/brandpublishing/localplus/usc-keck-cares/la-alzheimer-s-research-20160422-story.html.
[26] Google Patents. “7,053,109” Accessed February 3, 2017. https://patents.google.com/
patent/US7053109B2/en.
[27] LinkedIn. “Robert (Al) Chrusciel” Accessed February 3, 2017. https://www.linkedin.
com/in/robert-al-chrusciel-30a02b20.
[28] Google Patents. “7,067,507” Accessed February 3, 2017. https://patents.google.com/
patent/US7067507B2/en.
[29] Mary S. Easton Center. “John Varghese, Ph.D.” Accessed February 3, 2017. http://www.adc.ucla.edu/about-us/faculty-and-staff/item/john-varghese-phd.
[30] Google Patents. “7,060,870” Accessed February 3, 2017. https://patents.google.com/
patent/US7060870B1/en.
[31] University of Tennessee. “David Stern, MD” Accessed February 3, 2017. https://www.uthsc.edu/Medicine/about/administration/davidstern.php.
[32] Nolletti, Loralee. 2002. “Columbia Professor and Pfizer Inc. Sign Research Agreement for Testing Compounds with Possible Links to Alzheimer’s Disease” Columbia News Accessed February 3, 2017. http://www.columbia.edu/cu/news/02/01/pfizer_
biophysics.html.
[33] Google Patents. “7,067,550” Accessed February 3, 2017. https://patents.google.com/
patent/US7067550B2/en.
[34] Columbia University. “Stockwell Laboratory” Accessed February 3, 2017. http://www.columbia.edu/cu/biology/faculty/stockwell/Stockwell
Lab/index/pi-biography.html.
[35] Google Patents. “7,084,106” Accessed February 3, 2017. https://patents.google.com/
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[36] Virology & Mycology. “Girish J. Kotwal” Accessed February 3, 2017. https://www.omicsonline.org/editor-profile/Girish_Kotwal/.
[37] Google Patents. “7,109,217” Accessed February 3, 2017. https://patents.google.com/
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[38] Bloomberg. “Joseph P. Vacca, Ph.D.” Accessed February 3, 2017. http://www.
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[39] Vacca, Joseph P. 2012. “Approaches Toward New Alzheimer’s Treatments “ACS Medicinal Chemistry Letters Nov 8; 3(11): 861. doi: 10.1021/ml3003555. https://www.
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[40] Google Patents. “7,122,006” Accessed February 3, 2017. https://patents.google.com/
patent/US7122006B2/en.
[41] IPA. “Barry Reisberg” Accessed February 3, 2017. https://www.ipa-online.org/about-ipa/board-of-directors/barry-reisberg.
[42] Google Patents. “7,148,001” Accessed February 3, 2017. https://patents.google.com/
patent/US7148001B2/en.
[43] PharmaIn. “Management” Accessed February 3, 2017. http://pharmain.com/
management/.

Chapter 13

[1] Alzheimer’s Association. “Ted’s Story” Accessed February 3, 2017. http://www.alz.
org/living_with_alzheimers_8929.asp.
[2] Google Patents. “7,173,061” Accessed February 3, 2017. https://patents.google.com/
patent/US7173061B2/en.
[3] Bloomberg. “GE Healthcare Limited” Accessed February 3, 2017. http://www.
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[4] Google Patents. “7,176,290” Accessed February 3, 2017. https://patents.google.com/
patent/US7176290B2/en.
[5] Cure Alzheimer’s Fund. “Eva-Maria Mandelkow, Ph.D.” Accessed February 3, 2017. http://curealz.org/people/eva-maria-mandelkow.
[6] DZNE. 2013. “Pioneers in Alzheimer's Research: Bonn couple honored for its lifetime achievement - The scientists Eva-Maria and Eckhard Mandelkow receive award from U.S. Alzheimer's Association” Accessed February 3, 2017. https://www.dzne.de/en/
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[7] Google Patents. “7,179,463” Accessed February 3, 2017. https://patents.google.com/
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[8] Wikipedia. “Lars Lannfelt” Accessed February 3, 2017. https://translate.google.com/
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[9] Uppsala University. 2013. “Alzheimer's disease – soon just a memory?” Accessed February 3, 2017. http://www.uu.se/en/media/news/article/?id=3048&area=15,16&typ=
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[10] Google Patents. “7,179,605” Accessed February 3, 2017. https://patents.google.com/
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[11] Pivotal Therapeutics. “Senior Management” Accessed February 3, 2017. http://www.pivotaltherapeutics.us/?page_id=9.
[12] Google Patents. “7,186,881’ Accessed February 3, 2017. https://patents.google.com/
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[13] Myelin Repair Foundation. “Russell Rydel, Ph.D.” Accessed February 3, 2017. https://www.flickr.com/photos/myelinrepair
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[15] Facebook. “Dennis Elsberry” Accessed February 3, 2017. https://www.facebook.com/
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[18] PharmaIn. “Management” Accessed February 3, 2017. http://pharmain.com/
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[19] Google Patents. “7,205,008” Accessed February 3, 2017. https://patents.google.com/
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[20] The Michael J. Fox Foundation. “Alan D. Snow, PhD” Accessed January 30, 2017. https://www.michaeljfox.org/foundation/researchers.
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[21] Zerrouki, khayra. 2016. “Hypericum Perforatum Improve Memory And Learning In Alzheimer's Model: (Experimental Study In Mice)” International Journal of Pharmacy and Pharmaceutical Sciences May 20; 8(8) 49-57. https://innovareacademics.in/
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[23] PharmaIn. “Management” Accessed February 3, 2017. http://pharmain.com/
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[26] Google Patents. “7,214,715” Accessed February 3, 2017. https://patents.google.com/
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[27] David Geffen School of Medicine. “Barbara Jagodzinska, Ph.D.” Accessed February 3, 2017. http://www.eastonad.ucla.edu/research/drug-discovery-translational-laboratory/
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