Haplotype Analysis of Association between Parkinson’s Disease and the Embryonic Lethal, Abnormal Vision-Like 4 (ELAVL4) Gene

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Authors: Qiwen Liao, Anne Y. Y. Chan, H. Y. Edwin Chan, Vincent C. T. Mok, and Larry Baum
Page Range: 129-137
Published in: Journal of Biochemistry and Molecular Biology in the Post Genomic Era, 3#2 (2013)
ISSN: 2156-5732

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ISBN: N/A Categories: , ,

Table of Contents

ABSTRACT

Parkinson’s disease is a complex neurodegenerative disorder with both genetic and environmental risk factors. The embryonic lethal, abnormal vision-like 4 (ELAVL4) gene is located on chromosome 1p in the PARK10 locus, which has been associated with age at onset of PD. Seven SNPs of the ELAVL4 gene were genotyped through mass spectrometry. Individual associations between PD and each SNP were analyzed through the epitools package of R software. Haplotype analysis was performed using Haploview 4.2. No significant association was found between any of the SNPs and PD risk or age at onset. Haplotype analysis also showed no association with PD. As the number of PD cases was relatively small, a larger sample size might detect a modest association between ELAVL4 and PD, though a strong association is unlikely.

Keywords: neurodegeneration, polymorphism, Parkinson’s disease, neurogenetics, genetics

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