Gonadotropin-Releasing Hormone (GnRH): Production, Structure and Functions


Eric Scott-Sills, MD, PhD (Editor)
Pacific Reproductive Center, Orange County, CA, USA

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

This book offers updates on the full range of contemporary GnRH knowledge, as articulated by authoritative contributors with extensive neurophysiology experience. In this new comprehensive volume, internationally-renowned experts explain what GnRH is, describe how it works, follow its associated pathology, and predict where future GnRH research is likely headed. These objectives are clearly developed by sixteen concise yet thorough chapters covering themes across human clinical medicine, veterinary science, marine organisms, and transitional states as observed in so-called “living fossils”, as well as invertebrate biology.

The authors depict GnRH fundamentals as a starting-point for examination of more recent data in this rapidly evolving field. Although ideally suited for the senior GnRH researcher, anyone with an early, basic interest in neuroendocrinology will also find this book highly approachable. Fully illustrated, indexed and annotated, this edition is an essential item in any modern personal or institutional GnRH library collection. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents

Chapter 1 – Structure, Function and Evolutionary Aspects of Invertebrate GnRH and their Receptors
(Tsuyoshi Kawada, Masato Aoyama, Tsubasa Sakai and Honoo Satake, Bioorganic Research Institute, Suntory Foundation for Life Sciences, Osaka, Japan)

Chapter 2 – Reproductive Neuroanatomy and GnRH in the Primitive Vertebrate Order Myxiniformes (Hagfish Spp.)
(E. Scott Sills, School of Life Sciences University of Westminster, London, UK and Gianpiero D. Palermo,The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine/Weill Cornell Medical College; NY, NY, USA)

Chapter 3 – Dynamics of Three GnRH Forms in the Multiple Spawning Perciform Fish, Chub Mackerel, (Scomber japonicas) and Bambooleaf Wrasse (Pseudolabrus sieboldi)
(Sethu Selvaraj, Hajime Kitano and Michiya Matsuyama, Laboratory of Marine Biology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan and Masafumi Amano, School of Marine Biosciences, Kitasato University, Kanagawa, Japan)

Chapter 4 – Physiological Perspectives of GnRH in a Poultry and Farm Animal Context
(Ashish Mishra, Sukanta Mondal and I. J. Reddy, Animal Physiology Division, National Institute of Animal Nutrition and Physiology, Bangalore, India)

Chapter 5 – Avian GnRH: Production, Structure and Function
(Takayoshi Ubuka, Department of Biology, Waseda University; Shinjuku, Tokyo, Japan and George E. Bentley, Department of Integrative Biology and Helen Wills Neuroscience Institute, University of California at Berkeley; Berkeley, California, US)

Chapter 6 – Contraceptive Applications of GnRH-Analogs and Vaccines for Wildlife Mammals of Southern Africa: Current Experience and Future Challenges
(H. J. Bertschinger, Section of Reproduction, Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria; Pretoria, South Africa and E. Scott Sills, School of Life Sciences University of Westminster, London, UK)

Chapter 7 – Slow Release GnRH Agonist Implants for Males in Companion Animal Medicine
(Sandra Goericke-Pesch, Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University, Giessen, Germany)

Chapter 8 – Specific Regulation of Gonadotropin LHß- and FSHß-Subunit Gene Expression by Pulsatile GnRH Stimulation
(Haruhiko Kanasaki, Aki Oride and Kohji Miyazaki, Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan)

Chapter 9 – GnRH as a Local Mediator of Developmental and Physiological Processes in Mammalian Testis
(Shabana Anjum and Amitabh Krishna, Department of Zoology, Banaras Hindu University, Varanasi, India)

Chapter 10 – Anti-GnRH Receptor Monoclonal Antibodies as Bioequivalent Analogs of GnRH
(Gregory Lee, Hao Zhang and Yiting Tang, University of British Columbia Center for Reproductive Health, Vancouver, British Columbia, Canada)

Chapter 11 – Morphological Evidence for Involvement of Microglia in the Regulation of GnRH Neurons by Prostaglandins
(Hitomi Fujioka, Toshiya Funabashi and Tatsuo Akema, Department of Physiology, St. Marianna University School of Medicine, Kawasaki, Japan)

Chapter 12 – Gonadotropin Releasing Hormone Analogues in Assisted Conception
(Ilaria Totaro, Luigi Selvaggi and Raffaella Depalo, Unit of Pathophysiology of Human Reproduction and Gamete Cryopreservation, University Hospital Consorziale Policlinico, Bari, Italy)

Chapter 13 – GnRH-Agonist and Antagonist Protocols in Clinical IVF Practice: Patient Preference Comparisons Based on Cost and Number of Daily Injections
(E. Scott Sills, School of Life Sciences, University of Westminster, London, UK and Gary S. Collins, Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Oxford, UK)

Chapter 14 – GnRH Functions in Regulating Cell Proliferation and Migration: Mode of Action in Extra-Pituitary Organs
(Masahiro Enomoto, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto; Toronto, Ontario, Canada and Tomoko Kato, Yoh-Ichiro Kanaho, Mari Utsumi, and Min Kyun Park, Department of Biological Sciences, School of Science, The University of Tokyo; Bunkyo, Tokyo, Japan)

Chapter 15 – Inhibitory Effects of GnRH Receptor during Cell Invasion in the Breast Cancer Cell Line MDA-MB-231
(Arturo Aguilar-Rojas and Maira Huerta-Reyes, Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS), Morelos Mexico, Guadalupe Maya-Núñez and Fabián Arechavaleta-Velasco, Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad-Hospital de Ginecobstetricia No. 4; México D.F., MEXICO, P. Michael Conn, Oregon National Primate Research Center, Oregon Health Sciences University, Beaverton, OR, US, Alfredo Ulloa-Aguirre, Division of Reproductive Health, Research Center in Population Health, National Institute of Public Health; Morelos, Mexico and Jesús Valdés, Departament of Biochemistry, Centro de Investigación y de Estudios Avanzados (CINVESTAV); México D.F., Mexico)

Chapter 16 – GnRH-Based Drug Targeting: Cell Adhesion and Migration Modulator Effects of GnRH Derivatives in Tumor Cells
(László Kőhidai, Eszter Lajkó and Lívia Polgár, Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary, Ildikó Szabó and Gábor Mező, Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University; Budapest Hungary and Marilena Manea, Department of Chemistry and Zukunftskolleg, University of Konstanz; Konstanz Germany)

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