Glycocalyx and its Roles in Inflammation and Atherosclerosis


Ye Zeng
Associated Professor, Institute of Biomedical Engineering, West China school of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China

Series: Cell Biology Research Progress, New Developments in Medical Research
BISAC: SCI017000

The major component of glycocalyx, heparan sulfate covalently attaches to proteoglycan core proteins, which is abundant at the cell surface and in the extracellular matrix. Heparan sulfate could provide binding sites on endothelial cells to retain and activate highly diffusible cytokines and inflammatory chemokines to regulate cell functions, such as proliferation and migration. Under physiological and pathological conditions, the remodeling in structure of heparan sulfate including the abnormal expression, and irregular distribution that critically play a fundamental role in inflammation and atherosclerosis, as well as many other diseases was observed.

This book aims to integrate a current understanding of the identified molecular mechanisms in the regulation of glycocalyx, especially the heparan sulfate structure. Additionally, the available drugs that can protect the heparan sulfate or induce its synthesis, and the measurement techniques of the endothelial glycocalyx, as well as the relationship between structure and function of heparan sulfate in the progression of inflammation and atherosclerosis are analyzed. (Imprint: Nova Biomedical)


Table of Contents

Table of Contents



Chapter 1. Introduction and Overview

Chapter 2. Remodeling in Structure of Glycocalyx

Chapter 3. Measurement Techniques of the Endothelial Glycocalyx

Chapter 4. Association between Heparan Sulfate and Inflammation, Atherosclerosis

Chapter 5. Conclusion



Biographical Sketch


Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!