Glutathione S-Transferases: Structure, Functions and Clinical Aspects

Igor Azevedo Silva (Editor)

Series:  Medical Procedures, Testing and Technology



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Glutathione S-transferase (GST) isoenzymes are an important superfamily of proteins that are present in homodimer or heterodimer structures. The isoenzymes included in this superfamily are involved in endobiotic and xenobiotic detoxification systems in animals, plants and microorganisms.

This compilation focuses on the importance of functional aspects of polymorphic variants in different populations so the risk genotypes can be identified as indicators of disease susceptibility. Genetic studies will help to develop prognostic biomarkers for early prediction and risk assessment in patients, and enable clinicians to develop personalized treatment regimens.

The authors examine the different kinds of reactive oxygen species and reactive species which act as carcinogens and cause damage to DNA, RNA, proteins and lipids, thereby resulting in human disease like bladder cancer.

Also reviewed is the association of GST’s common genetic variants with the development of infertility (failure to establish a clinical pregnancy after 12 months of regular, unprotected sexual intercourse) in women and in men.


Chapter 1. An Overview of the Glutathione S-Transferase Family: Structure, Classifications and Clinical Implications
(Sètondji Cocou Modeste Alexandre Yahouédéhou and Marilda Souza Goncalves, PhD, Instituto Gonçalo Moniz, Salvador, Bahia, Brasil)

Chapter 2. Genetics of Glutathione S-Transferase and Complex Diseases
(Atar Singh Kushwah and Monisha Banerjee, Molecular and Human Genetics Laboratory, Department of Zoology, University ofLucknow, Lucknow, India, and others)

Chapter 3. Antioxidant Activity of Glutathione S-Transferases and Their Association with Bladder Cancer
(Md. Bayejid Hosen and Yearul Kabir, PhD, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh)

Chapter 4. Glutathione S-Transferases in Infertility
(Maria Manuel Casteleiro Alves, António Hélio Oliani, Luiza Breitenfeld and Ana Cristina, Ramalhinho, CICS-UBI – Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal, and others)


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