Glutathione: Biosynthesis, Functions and Biological Implications


Pál Perjési, Ph.D. (Editor)
Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

Glutathione (GSH) is a ubiquitous tripeptide (γ-L-glutamyl-L-cysteinyl-glycin) playing an important role in cellular redox homeostasis, defense against electrophilic reactive species, and control of several cellular events, among others. Most of these cellular functions are related to its thiol (SH) function of the cysteine moiety. With increasing knowledge on the molecular basis of its cellular functions, use of GSH as a nutritional supplement is receiving increasing interest. The present book summarizes the recent literature and new developments on three distinct, but closely related topics: Production, biochemical functions, implications and applications of glutathione. The topics cover comprehensive reviews on physico-chemical characterization, pharmacopoeial qualification, biotechnological production, surveys on different analytical methods for its quantitation, and the role of several physiological abnormalities (e.g., cardiac diysfunctions, neurological disorders, kidney injuries and different types of cancer) related to non-appropriate biosynthesis and/or metabolism of endogenous GSH. The information presented represents a valuable source for advanced students, scholars, teachers and scientists (academic and industrial) interested or already engaged in research that involves glutathione.

Table of Contents

Table of Contents


Session I. Synthesis -Biosynthesis

Chapter 1. Physico-Chemical Characterization of Glutathione (GSH)
(Pál Perjési, Caridad Noda Perez, Hamilton B. Napolitano and Hawsar O. Mohammed, Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary, and others)

Chapter 2. Glutathione and Related Compounds Produced by Glutathione-Synthesizing Pathway
(Junichi Fujii, Sho Kobayashi and Takujiro Homma, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan)

Chapter 3. Genetic Engineering of Microorganisms for High Glutathione Production
(Jyumpei Kobayashi, Daisuke Sasaki, Kiyotaka Y. Hara and Akihiko Kondo, Graduate School of Science, Technology, and Innovation, Kobe University, Hyogo, Japan, and others)

Chapter 4. Regulating of Glutathione Synthesis in Yeast Using Combinational Genetic Strategies
(Wenlong Zhou and Wei Wang, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China)

Session II. Functions-Malfunctions

Chapter 5. Glutatione and Glutathione-Dependent Enzymes in Redox Regulation of Cellular Processes
(Elena. V. Kalinina, Nikolai. N. Chernov and Maria. D. Novichkova, T.T. Berezov Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation)

Chapter 6. Diverse Effects of Glutathione in the Pathophysiology of Some Organ Diseases
(Janka Vašková, Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic)

Chapter 7. Genetic Polymorphism of Glutathione S-Transferase
(Mariana Chantre-Justino and Gilda Alves, Department of Pathology, Faculty of Medical Sciences, State University of Rio de Janeiro Rio de Janeiro, Brazil)

Chapter 8. The Role of Glutathione in Toxicity of Drugs and Xenobiotics
(Tomáš Roušar, Department of Biological and Biochemical Sciences, University of Pardubice; Pardubice, Czech Republic)

Session III. Implications-Applications

Chapter 9. Detection and Quantitation of GSH and GSSG
(Hui Wang, Xiaojing Yang and Jiang Zheng, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China, and others)

Chapter 10. A Glutathione Sensor Based on CdO-Decorated CNT Nanocomposites
(Mohammed M. Rahman, Mohammad M. Hussain and Abdullah M. Asiri, Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia, and others)

Chapter 11. The Role of Glutathione in Sperm Resistance to Cryopreservation
(Dario Santos and Rita Payan-Carreira, CITAB & Department of Biology and Environment, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal, and others)

Chapter 12. The Chemistry of GST-Catalyzed Reactions
(Pál Perjési, Caridad Noda Perez, Aline Bernardes, Giulio D. d’Oliveira and Fatemeh Kenari, Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary)


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