Glioblastoma: State-of-the-Art Clinical Neuroimaging (2 Volume Set)


Michael Iv, M.D., Max Wintermark, M.D. and Tarik F. Massoud, M.D., Ph.D. (Editors)
Department of Radiology, Stanford University, School of Medicine, Stanford, CA, USA

Series: Neuroscience Research Progress
BISAC: MED019000

Neuroimaging plays a central role in the initial diagnosis and subsequent monitoring of multimodal therapies offered to patients with glioblastoma – the most malignant type of brain cancer. The authors present a comprehensive description of current state-of-the-art clinical neuroimaging for glioblastoma. They cover the basic concepts and most recent applications of clinical structural neuroimaging, as well as the latest innovations and up-and-coming techniques for functional imaging of glioblastoma patients.

Few comprehensive books are available in this challenging field of clinical medicine. The co-editors are experienced academic neuroradiologists with an active interest in clinical imaging and research of glioblastoma, all within a vibrant clinical environment at Stanford University where the latest innovations in glioblastoma imaging and treatment are being developed. In compiling this book, the co-editors have called upon many of the world’s best clinical and basic neuroscientists specializing in the management of patients with this malignancy, for their expert input on the latest imaging developments and applicable research into glioblastoma.

This book is intended for neuroradiologists, neuro-oncologists, neurosurgeons, radiation therapists, and other physicians and scientists engaged in the study and clinical management of patients with glioblastoma. It should also serve as a unique educational and research resource for students and more experienced practitioners alike within this rapidly evolving field.


Table of Contents

Table of Contents

Volume 1

(Soonmee Cha, MD, University of California, San Francisco Medical Center, San Francisco, CA, US)

(Michael Iv, MD, Max Wintermark, MD, and Tarik Massoud, MD, PhD)

Introduction: Overview of Glioblastoma Imaging
(Erik Velez, MD, Daniel Chow, MD, Meng Law, MD, USC Keck Medical Center, Department of Radiology, Los Angeles, CA, US and others)

Chapter 1. WHO Classification of Glioblastoma: An Overview
(Maria Martinez-Lage, MD, Assistant Professor of Pathology, Harvard Medical School, Boston MA, US, and others)

Chapter 2. Glioblastoma Epidemiology
(Catherine R. Garcia, Jigisha P. Thakkar, and John L. Villano, MD, PhD, Departments of Internal Medicine, Neurology, Neurosurgery, Markey Cancer Center, University of Kentucky, Lexington, KY, US)

Chapter 3. Overview of Glioblastoma Biology
(Chibawanye I. Ene, MD, PhD, Eric C. Holland, MD, PhD, Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, US)

Chapter 4. Overview of Molecular Markers of Glioblastoma
(Kirsten Ludwig, PhD and Harley I. Kornblum MD, PhD, Semel Institute for Neuroscience and Human Behavior and the Departments of Psychiatry and Biobehavioral Research, Molecular and Medical Pharmacology and Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, US)

Chapter 5. Genetic Profiles and Familial Syndromes of Glioblastoma
(Ben Kinnersley, PhD, and others Richard S Houlston MD, PhD, Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK)

Chapter 6. Pathology of Glioblastoma: An Overview
(Hannes Vogel, MD, Department of Pathology, Stanford University School of Medicine, Palo Alto, CA, US)

Chapter 7. Imaging of Low Grade Gliomas
(Bernadine Quirk, Steffi Thust, MD, Tarek A. Yousry, Dr Med Habil, Lysholm Neuroradiology Department, National Hospital for Neurology and Neurosurgery, London, UK)

Chapter 8. Pediatric High-Grade Glioma
(Joy Q. He, Nicholas S. Whipple and Samuel H. Cheshier, Pediatric Neurosurgery, Huntsman Cancer Institute, University of Utah, Utah, CA, US)

Chapter 9. Glioblastoma of the Spinal Cord in Adults
(Yagmur Muftuoglu, Allen L. Ho, MD, Eric S. Sussman, Arjun V. Pendharkar, and Atman M. Desai, Department of Neurosurgery, Stanford Neuroscience Health Center, Palo Alto, CA, US, and others)

Chapter 10. Less Common Locations and Appearances of Glioblastoma
(Young W. Kim, MD, and Tarik F. Massoud, MD, PhD, Division of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, CA, US)

Chapter 11. Extra-Axial Systemic Spread of Glioblastoma
(Michael K. Wang, MD, and Tarik F. Massoud, MD, PhD, Division of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, CA, US)

Chapter 12. Structural MRI and CT Features of Glioblastoma and Differential Diagnosis
(Byung C. Yoon, MD, PhD, Xiaobai Liu, MD, Rhea Singh, Syed Hashmi, MD and Michael Iv, MD, Department of Neuroradiology, Stanford University, CA, US)

Chapter 13. Role of Diffusion-Weighted Imaging in Glioblastoma Evaluation
(Hsu Kevin, MD, Xiaobai Liu, MD, Rhea Singh, Syed Hashmi, MD and Michael Iv, MD, Department of Neuroradiology, Stanford University, CA, US)

Chapter 14. Perfusion Imaging of Glioblastoma
(Brent Griffith, Josep Puig and Rajan Jain, Department of Radiology, Henry Ford Health System, Detroit, MI, US, and others)

Chapter 15. Magnetic Resonance Spectroscopy of Glioblastoma
(Sarah J. Nelson, PhD, Yan Li, PhD, Ilwoo Park, PhD, and Susan M. Chang, MD, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, US)

Chapter 16. Diffusion Tensor Imaging and Tractography of Glioblastoma
(Choukri Mekkaoui, PhD, Susie Y. Huang, MD, PhD, Marcel P Jackowski, PhD, Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, US, and others)

Chapter 17. Functional MRI in Glioblastoma
(Maria Elena Laino, MD, Kyung K. Peck, PhD, and Andrei I. Holodny, MD, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, US, and others)

Chapter 18. PET Imaging of Glioblastoma
(Ida Sonni, MD, Tomomi Nobashi MD, PhD, and Andrei Iagaru, MD, Lawrence Berkeley National Laboratory, Department of Molecular Biophysics and Integrated Bioimaging, Berkeley CA, US, and others)

Volume 2

Chapter 19. Quantitative Image Analysis of Glioblastoma
(Olivier Gevaert, PhD, Stanford Center for Biomedical Informatics Research, Department of Medicine, and Department of Biomedical Data Science, Stanford University, Stanford, CA, US)

Chapter 20. MRI Phenotypes and Radiogenomics of Glioblastoma
(Charles Beaman, MD, Islam Hassan, MD, Rivka Colen, MD, Houston, TX, US, and others)

Chapter 21. Treatment of Glioblastoma and Associated Imaging: A Neuro-Oncology Perspective
(Judith Shanika Pelpola, Siyu Shi, Yanet Wossenseged and Reena Thomas, MD, PhD, Department of Neurological Sciences, Stanford School of Medicine, Stanford, CA, US)

Chapter 22. Pre-Operative Planning for Glioblastoma Surgery: Diagnosis, Surgical Approach, and Future Applications
(Melanie Hayden Gephart, MD, and Pierre Robe, Associate Professor of Neurosurgery, Stanford University, Stanford, CA, US)

Chapter 23. Glioblastoma: What the Neurosurgeon Needs to Know – Intra-Operative MRI and Fluorescence Imaging
(Linda W. Xu, Michael Zhang and Gordon Li, Department of Neurosurgery, Stanford Health Care, Palo Alto, CA, US)

Chapter 24. Glioblastoma: A Radiation Oncology Perspective
(Scott G. Soltys, MD, and Erqi Pollom MD, Department of Radiation Oncology, Stanford Cancer Institute, Stanford University, Stanford, CA, US)

Chapter 25. Intra-Arterial Chemotherapy Treatment of Glioblastoma
(David Fortin, MD, Surgery Department, Neurosurgery and Neuro-Oncology Division, Universite de Sherbrooke, Sherbrooke, Quebec, Canada)

Chapter 26. Immune Cell Therapy and Imaging of Glioblastoma
(Surya Murty and Sanjiv Sam Gambhir MD, PhD, Department of Radiology, Stanford University, Stanford, CA, US)

Chapter 27. MRI-Guided Focused Ultrasound Therapy for Glioblastoma
(Daniel Coluccia, MD, Nicole Frank, MD, and Beat Werner, Department of Neurosurgery, Luzerner Kantonsspital, Lucerne, Switzerland)

Chapter 28. Electric Field Therapy of Glioblastoma
(Edwin Lok, Kenneth D. Swanson, PhD, Eric T. Wong, MD, Brain Tumor Center and Neuro-Oncology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US, and others)

Chapter 29. MRI-Guided Laser Induced Thermal Therapy of Glioblastoma
(Julie E. King and Jacqueline A. Johnson, PhD, Biomedical Enginerring, University of Tennessee Space Institute, Tullahoma, TN, US, and others)

Chapter 30. Imaging of Glioblastoma Treatment: Response and Pseudoresponse
(Steffi Thust, MD, Harpreet Hyare, PhD and Jeremy Rees, PhD, Department of Brain, Repair and Rehabilitation, UCL Institute of Neurology, London, UK, and others)

Chapter 31. Imaging Complications of Glioblastoma Treatment
(Tomasz Matys, MD, PhD, and Fulvio Zaccagna, MD, Department of Radiology, University of Cambridge, Cambridge, United Kingdom)



Glioblastoma: State-of-the-Art Clinical Neuroimaging is much more than its title implies: it is the best and most comprehensive treatise on the subject. Edited and written by a cadre of world-renowned researchers and clinicians it provides an all-inclusive and systematic review of this rare but fascinating disease. It not only reviews what we knew, but also what we now know, and more importantly, what we should know about glioblastoma. This book belongs in the library of anyone who deals with patients and those researchers attempting to further elucidate glioblastoma.” – Mauricio Castillo, MD, FACR. JH Scatliff Distinguished Professor, Chief of Neuroradiology, Department of Radiology, University of North Carolina at Chapel Hill School of Medicine, USA

Glioblastoma: State-of-the-Art Clinical Neuroimaging represents a tour-de-force by not only discussing the mechanics of imaging but also by placing the imaging in context. Expert input from a wide range of experts is augmented by expertise in the biology, classification and epidemiology of glioblastoma and authoritative input on all aspects of clinical management. This book will therefore be an extremely useful reference work for imagers, clinicians and scientists alike. The level of detail is both broad and deep involving 32 chapters across 2 volumes and will prove a valuable addition to any office or library. Importantly the book emphasizes the importance of a multidisciplinary approach to understanding and treating this devastating disease.” – Colin Watts, MB BS, PhD, FRCS(SN). Professor of Neurosurgery, Chair Birmingham Brain Cancer Program, University of Birmingham College of Medical and Dental Sciences, UK

“In an age when one is increasingly reliant on gathering information from multiple sources on the internet — and sometimes spending many fruitless hours searching for reliable material — this book offers a refreshing solution. Herein, important information from the best and brightest investigators in the field of glioblastoma is provided in a comprehensive manner. This book has something to offer anyone involved in brain tumor clinical care and research. Excellent material on the rapidly advancing fields of radiogenomics, quantitative image analysis, and other forms of advanced imaging is delivered. However, the book is not solely oriented towards imaging; it offers exceptional perspectives from the viewpoint of the neurosurgeon, neuro-oncologist and radiation oncologist. For the clinician or researcher who seeks an all-inclusive understanding of glioblastoma, “Glioblastoma: State-of-the-Art Clinical Neuroimaging” will serve as an essential resource.” – James M. Provenzale, MD, FACR. Professor, Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, USA

“I congratulate the editors and authors of this outstanding and comprehensive resource book on glioblastoma. It’s all here—compilation of essential information on biology, imaging, treatment and much more on glioblastoma.” Soonmee Cha, MD, Professor of Radiology and Neurological Surgery; Program Director, Diagnostic Radiology Residency; Vice Chair of Education; Department of Radiology and Biomedical Imaging, University of California, San Francisco Medical Center, San Francisco, CA, USA


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