Glioblastoma Multiforme: Symptoms, Diagnosis, Therapeutic Management and Outcome


Isabelle M. Germano, MD (Editor)
The Mount Sinai Medical Center, New York, NY, USA

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED056000

This book provides basic researchers and clinicians with a contemporary review of personalized medicine for the diagnosis and treatment of Glioblastoma Multiforme (GBM), the most common and most aggressive type of brain tumor. Over the past decade, there has been an explosion of basic and clinical research revolving around GBM, resulting in improved outcomes and, most importantly, significant advances in our ability to better understand this disease to formulate personalized medical treatment for each patient. It is important to note that the word multiforme means “of many forms or appearances”, implying that “one treatment will not fit all”.

Data from a variety of sources show that medical decisions and interventions must be tailored to the individual patient to obtain the greatest outcome. In this book, the diagnostic techniques and treatment options for patients with GBM are reviewed in state-of-the-art chapters written by expert researchers and clinicians in the field focusing on molecular genetic classification, surgical management, chemotherapy, radiation, nutrition, immune-therapy, and more. Many new therapeutic options are described and reviewed, confirming that not only does each patient needs to have personalized treatment, but also that a single treatment alone will not be sufficient; multiple mechanisms are involved and tumor biology changes over time. Hopefully, this book will educate and stimulate readers’ knowledge and lead to new avenues of investigation and therapeutic success.
(Imprint: Nova Biomedical)

Table of Contents

Table of Contents

pp. ix-x

Chapter 1
Presenting Symptoms in Patients with Glioblastoma Multiforme
(Ioannis N. Mavridis, Maria Meliou, Efstratios-Stylianos Pyrgelis, Department of Neurosurgery, ‘K.A.T.-N.R.C.’ General Hospital of Attica, Athens, Greece, and others)
pp. 1-14

Chapter 2
Diagnostic and Intra-Operative Imaging for Glioblastoma Multiforme
(Roy G. Torcuator, Alexandra Golby, International Institute for Neurosciences, St. Luke’s Medical Center-Global City, St Luke’s College of Medicine, Philippines, and others)
pp. 15-30

Chapter 3
Histological and Molecular Diagnosis of Glioblastoma Multiforme
(Nadejda M. Tsankova, Armine Darbinyan, Mary Fowkes, Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, and others)
pp. 31-44

Chapter 4
Surgical Resection: Techniques, Intra-Operative Update and Outcome
(Oliver Schnell and Jörg-Christian Tonn, Dept. of Neurosurgery, Klinikum der Ludwig-Maximilians-Universität München, Campus Großhadern, Munich, Germany)
pp. 45-60

Chapter 5
Adjuvant Therapy for Patients with Newly Diagnosed Glioblastoma
(Rebecca Fisher, Adília Hormigo, Departments of Neurology and 2Medicine and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA)
pp. 61-72

Chapter 6
Radiation and Re-Irradiation for Patients with Glioblastoma Multiforme
(Todd J. Carpenter and Sheryl Green, Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, NY, NY, USA)
pp. 73-84

Chapter 7
Diet and Other Metabolic Approaches for Patients with Glioblastoma Multiforme
(Andrea Carai, Alessandro De Benedictis, Francesca Del Bufalo, Raffaella Messina, Franco Randi, Angela Mastronuzzi, Neurosurgery Unit, Department of Neurosciences and Neurorehabilitation, and Department of Onco-HematologyBambino Gesù Children Hospital, Rome, Italy)
pp. 85-98

Chapter 8
Reoperation for Recurrent Glioblastoma Multiforme
(Christopher A. Sarkiss & Raymund L. Yong, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai and Mount Sinai Hospital; New York, New York, USA)
pp. 99-112

Chapter 9
Chemotherapy Options for Patients with Recurrent Glioblastoma Multiforme
(Bela Piko, Ibolya Laczo, Robert Vendrey, Bassam Ali, Enikő Török, “Pándy Kálmán” Békés County Hospital, Gyula, Hungary)
pp. 113-122

Chapter 10
The Role of Biomarkers in Glioblastoma Diagnosis: Will Tissue Diagnosis Still be Needed?
(Ian F. Parney, Alberto Malucelli, Michael P. Gustafson, Allan B. Dietz, Department of Neurological Surgery, Mayo Clinic, MN, USA, and others)
pp. 123-134

Chapter 11
Immunotherapy: Present and Future Directions
(Debebe Theodros, Eric W. Sankey, C. Rory Goodwin, Michael Lim, The Johns Hopkins University School of Medicine, The Johns Hopkins University Department of Neurosurgery, The Johns Hopkins Hospital
Baltimore, Maryland USA)
pp. 135-148

pp. 149-151

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