Glial Cells: Embryonic Development, Types/Functions and Role in Disease


Charanjit Kaur, PhD and Ling Eng Ang, PhD (Editors)
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Series: Neuroscience Research Progress, Cell Biology Research Progress
BISAC: MED057000

This book contains nine chapters which include contributions by different experts who have been very active in glia research over the past several years. The contributions are comprehensive keeping abreast with the latest developments on glia research. Different aspects of glia research are discussed, such as their embryonic development and role in the developing and adult brain, both in health and disease. Chapter One deals with the development of macroglial cells; Chapter Two addresses the role of glial cells in periventricular white matter damage in hypoxic neonatal brains; the role of microglia and astrocytes in neuroinflammation has been addressed in Chapter Three; involvement of glia in the pathology of variant Creutzfeldt-Jakob disease and in osterarthritic pain is detailed in Chapters Four and Seven respectively; Chapter Five deals with examination of astrocytic markers in adult and pediatric neurological disorders with regard to changes in cerebrospinal fluid and/or serum levels of glial fibrillary acidic protein and S100 calcium-binding protein B; Chapter Six focuses on the modulation of glial cell responses by insulin; Chapter Eight describes the current understanding of the biophysiological properties, proposed functions and modulatory molecules of BK channels (a subtype of Ca2+-activated K+ (KCa) channels) in microglia; and the physiological interactions between neurons and glia are discussed in chapter nine. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Chapter 1. Macrolial Cells: Development, Types/Functions and Role in Disease
(Luciana Nogaroli and Marcos R. Costa, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, and others)

Chapter 2. Role of Glial Cells in Periventricular White Matter Damage in Hypoxic Neonatal Brains
(Gurugirijha Rathnasamy, Madhuvika Murugan, Eng-Ang Ling and Charanjit Kaur, Department of Anatomy, MD10, Yong Loo Lin School of Medicine, National University of Singapore, Singapore)

Chapter 3. Role of Microglia and Astrocytes in the Process of Neuroinflammation
(Anna K. Bal-Price and Agnieszka Kinsner-Ovaskainen, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra (VA), Italy)

Chapter 4. Glia and the Pathology of Variant Creutzfeldt-Jakob Disease (vCJD)
(Richard A. Armstrong, Vision Sciences, Aston University, Birmingham, UK)

Chapter 5. Glial Fibrillary Acidic Protein and S100 Calcium-Binding Protein B In the Cerebrospinal Fluid of Children with Acute Neurological Disorders
(Keisuke Nakajima, Masaharu Hayashi, Rie Miyata, Naoyuki Tanuma and Shuki Mizutani, Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan, and others)

Chapter 6. Regulation of Glial Metabolism and Immune Responses by Insulin
(Manpreet Bahniwal, Jonathan P. Little and Andis Klegeris, Department of Biology, University of British Columbia Okanagan Campus, Kelowna, BC, Canada)

Chapter 7. Glial Cell Involvement in Osteoarthritic Pain
(Frank B. Wydra, Bryan M. Saltzman, Kasra Ahmadinia, Jae-Sung Kim and Hee-Jeong Im, Rush University Medical Center, Chicago, IL, USA)

Chapter 8. BK+ Channels Contribute to the Cellular Activation of Microglia: A Big Channel in Small Glia (Yoshinori Hayashi and Hiroshi Nakanishi, Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan and others)

Chapter 9. Physiological Interactions between Neurons and Glia: Roles of Transporters in the Control of Intersynaptic Crosstalk
(Shiro Konishi and Shin’Ichiro Satake, Department of Neurophysiology, Kagawa School of Pharmaceutical Sciences and Institute of Neuroscience, Tokushima Bunri University, Sanuki, Japan and others)



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