Ginger’s Antimicrobial, Anti-Nausea and Anti-Osteoarthritic Activities


Series: Natural Products and Therapeutics
BISAC: HEA017000; HEA011000

Ginger has a strong reputation as an anti-nausea agent but our understanding of the roles played by its important biological constituents (gingerols and shogaols) as antimicrobial and anti-inflammatory agents has not been examined in detail. This series of monographs seeks to look first at how and why ginger was used as an ethnomedicine and how this expanded into general antimicrobial studies. One cardinal use for ginger and its constituents may be in the topical management of osteoarthritis. Given the widespread nature of this condition and ginger’s ability to block pain receptors it may join other molecules such as capsaicin in this mode of treatment.

Table of Contents


Chapter 1. Ginger and the Gastrointestinal Tract: Bioactive Effector Molecules and Possible Future Uses
(Diana R. Cundell – College of Life Sciences, Jefferson University, Philadelphia, PA, USA)

Chapter 2. Ginger as an Antibacterial Agent
(Manuela Tripepi, Mary-Ann Wagner-Graham, Madison Bright, Nicholas Wahba and Maithili Patel – College of Life Sciences, Jefferson University, Philadelphia, PA, USA)

Chapter 3. Ginger as an Antifungal Agent
(Anne H. Bower, Tyler Savage, Irene Cooper and Brianne Spellman – College of Life Sciences, Jefferson University, Philadelphia, PA)

Chapter 4. Ginger as an Antiviral Agent
(Frank H. Wilkinson – College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, USA)

Chapter 5. Ginger and Osteoarthritis: Current Evidence for Efficacy and Possible Future Uses for Effective Delivery Systems
(Diana R. Cundell and Karren K. Jensen – College of Life Sciences, Jefferson University, Philadelphia, PA, US, et al.)


Book Review

“I found Drs. Cundell and Jensen’s chapter on ginger both well-written and well researched.  We chiropractors take a biomechanical approach to osteoarthritic degenerative changes, focusing on dyskinesis of the motion units of the spine.  As the work of Donald Harrison, PhD, DC, and others has demonstrated, aberrant forces are generated on spinal structures as they deviate from ideal alignment, particularly in the coronal and sagittal planes.  These deviations (e.g. poor posture) and their concomitant compressive and shearing forces lead to hypo-mobility of the motion unit as well as hyper-mobility in adjacent motion units as compensation.  So, the question is how do those mechanical forces lead to a breakdown in the tissues? Cundell and Jensen’s chapter helps answer this by mapping out the biochemical pathways that cause these destructive changes.  It explains the degenerative processes clearly and illustrates them concisely in Figure 1 of the chapter.  Their chapter and the associated references also make it easy to pursue more detailed knowledge of the biochemistry of OA for anyone interested.” – Dr. Anthony Galzarano, Owner, Wissahickon Chiropractic, Pennsylvania, USA

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