Ghrelin: Function, Mechanism of Action and Role in Health and Disease

Dennis Hertz (Editor)

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Ghrelin is a 28-amino acid peptide mainly secreted by the stomach. To better understand the role of ghrelin signaling, Ghrelin: Function, Mechanism of Action and Role in Health and Disease first explores the regulation of age-associated adipose tissue inflammation.

Following this, the authors discuss the influence of different variables on the response of short-term appetite regulation induced by exercise. External factors such as temperature and environment exert effects on hormonal responses, including hunger sensation and energy intake.

The effects of gender differences and aging on psychological stress-dependent eating disorders are assessed, and the involvement of endogenous ghrelin, the serotonin 2c receptor and the estrogen alpha receptor is discussed.

The penultimate chapter reviews the relationship between sleep and eating behavior, focusing in the influences of circadian changes on appetite related responses such as plasma concentration of ghrelin.

The concluding study highlights the ghrelin system as a promising candidate for cardiovascular drug discovery, a new therapeutic approach for the treatment of endothelial impairment, and a possible contribution to the prevention of atherosclerosis.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Relationship of Ghrelin with Appetite and Aging
(L. Manuel-Apolinar, L. Basurto-Acevedo, M. P. Cruz Domínguez, T. Pérez-Capistran and L. Damasio, Unidad de Investigación Médica en Enfermedades Endócrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico, and others)

Chapter 2. Influence of the Environment and Temperature in Acute Exercise-Induced Appetite Regulation
(Randhall B. K. Carteri and Rafael Genario, Department of Department of Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil, and others)

Chapter 3. Abnormal Ghrelin Dynamics in Psychological Stress-Induced Eating Disorders: Influence on Gender Difference and Aging
(Chihiro Yamada, PhD, Tsumura Kampo Research Laboratories, Tsumura & Co., Japan)

Chapter 4. Sleep and Eating Behavior: Relationship with Ghrelin
(Rafael Genario, Cassiano Diniz and Randhall Bruce Carteri, University of Passo Fundo, Passo Fundo, Brazil, and others)

Chapter 5. The Role of Ghrelin in Vascular Tone Regulation in Relationship with Oxidative Stress and Lipids
(L. Manuel Apolinar, N. A. Estrada-Cruz, D. H. Montes Cortés, M. Díaz-Flores and A. Chavez-Negrete, Unidad de Investigación Médica en Enfermedades Endócrinas, Hospital de Especialidades, Centro Médico Nacional, Instituto Mexicano del Seguro Social, Ciudad de México, México, and others)

Index

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