Gentamicin: Biosynthesis, Medicinal Applications and Potential Side Effects

Emilie Kruger (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED022090

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Gentamicin is an aminoglycoside antibiotic naturally synthesized by Micromonospora, a Gram-positive genus of bacteria widely found in water and soil. This antibiotic is useful against a wide variety of bacteria, and works by binding the 30S subunit of the bacterial ribosome, which interrupts bacterial protein synthesis.

In this book, the authors discuss the biosynthesis, medicinal applications and potential side effects of Gentamicin. Topics include Gentamicin used in combination therapy and applied to medicinal materials for clinical applications; use of natural products to enhance the antibiotic activity of Gentamicin and other aminoglycosides; regiospecific Gentamicin functionalization; Gentamicin and particle engineering; and the indications and adverse effects of Gentamicin. (Imprint: Nova Biomedical )

Preface

Medicinal Application of Gentamicin: From Past to Future
(Changhua Chen, Yumin Chen, Baoyuan Chen, Division of Infectious Diseases, Departments of Internal Medicine and Pharmacy, Changhua Christian Hospital, Changhua, Taiwan)

Gentamicin and Particle Engineering: From an Old Molecule to Innovative Drug Delivery Systems
(Giulia Auriemma, Mariateresa Stigliani, Paola Russo, Pasquale Del Gaudio, Rita P. Aquino, Department of Pharmacy, University of Salerno, Fisciano, Italy)
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Use of Natural Products to Enhance the Antibiotic Activity of Gentamicin and other Aminoglycosides: The Future of Antibiotic Therapy
(Cícera Natalia Figueirêdo Leite Gondim, Nadghia Figueiredo Leite, Jacqueline Cosmo Andrade, Maria Flaviana Bezerra Morais-Braga, Glaucia Morgana de Melo Guedes, Saulo Relison Tintino, Cícera Cislânia Araújo Tavares, Maria Audilene de Freitas, Liscássia Beatriz Batista Alencar, Celestina Elba Sobral de Souza, Rosimeire Sabino Albuquerque, Edinardo Fagner Ferreira Matias, Francisco Assis Bezerra da Cunha, Dara Isabel Vieira de Brito, Anne Karyzia Lima Santos de Lavor, João Victor de Alencar Ferreira, Fernando Gomes Figueredo, Luciene Ferreira de Lima, Henrique Douglas Melo Coutinho, Universidade Regional do Cariri-URCA, Brazil)

Regiospecific Gentamicin Functionalization: Design for Particular Applications
(Jonathan Grote, Richard Himmelsbach, Don Johnson, Organic Chemistry Process Research, Abbott Diagnostics Division, Abbott Park, IL, USA)

Indications and Adverse Effects of Gentamicin
(Lorena Giner-Bernal, Jaime Ruiz-Tovar, Antonio Arroyo, Rafael Calpena, General University Hospital Elche, Alicante, Spain)

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