Genistein and Daidzein: Food Sources, Biological Activity and Health Benefits

Masayoshi Yamaguchi, PhD (Editor)
Department of Hematology and Medical Oncology, Emory University, School of Medicine, Atlanta, Georgia, USA

Series: Nutrition and Diet Research Progress
BISAC: HEA048000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Soybeans are greatly used in many foods, such as tofu, soy milk and yogurt, and it plays an important role as a functional food in the health and prevention of various diseases. Soybeans contain rich isoflavones including genistein, daidzein and glycitein, and both genistein and daidzein occur at higher concentrations.

Isoflavones are structurally and functionally similar to 17ß–estradiol. Isoflavones are found to bind to estrogen receptors and the peroxisome proliferator-activated receptor (PPAR) family and aryl hydrocarbon receptors. Moreover, isoflavones affect activity of tyrosine kinases, histones, transcription factors, adenosine mono phosphate pathways, RNA expression and other intracellular regulators. Thus, isoflavones play a multifunctional role in cell regulation. This book focuses on recent advances in the food sources, biological activity and health benefits of genistein and daizen.

(Imprint: Nova)


1. Effects of Genistein and Daidzein in Female Reproductive Tract
(Adriana Aparecida Ferraz Carbonel, Luciana de Oliveira Bruno, Cristiane de Paula Teixeira, Ricardo Santos Simões, João Henrique Castello Girão, Manuel de Jesus Simões, and Clélia Rejane Antonio Bertoncini, Department of Morphology and Genetic, Histology and Structural Biology Division, São Paulo Federal University (UNIFESP/EPM), Brazil, and others)

2. Daidzein and Genistein: Endothelial Action of an Aglycone-Rich Extract
(Camila Marques de Andrade, Maria José Vieira Fonseca, Maria Regina Torqueti Toloi, University of São Paulo, Faculty of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical, Toxicological and Bromatological Analysis, Ribeirão Preto, Brazil, and others)

3. Role of Genistein in Bone Homeostasis: Prevention of Osteoporosis
(Masayoshi Yamaguchi, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, USA)

4. Contemporary Clinical Effects of Phytoestrogens Administration
(Milan Terzic, Jelena Dotlic, Clinical Center of Serbia, Clinic of Obstetrics and Gynecology, Dr Koste Todorovica 26, Belgrade, Serbia, and others)

5. Bone Formation: Roles of Genistein and Daidzein
(Marjorie Bateman, Amy L. Strong, Matthew E. Burow, Guangdi Wang, Stephen M. Boue, Bruce A. Bunnell, Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA)


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