Gene-Environment Interactions and Human Diseases

Lu Qi, MD, PhD (Editor)
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, Tulane University Obesity Research Center, New Orleans, LA, USA

Series: Genetics – Research and Issues
BISAC: SCI029000

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With tremendous success of genomic research in discovering genetic variations determining human diseases, it is now time to re-evaluate how the environment affects disease risk by taking into consideration these genetic findings. This book addresses a rapidly growing interest in assessing the relations between environmental risk factors (such as diet, lifestyle) and human diseases, by considering the potential roles of genomic make-up. The book brings together a selection of chapters written by specialists with a variety of backgrounds such as epidemiology, nutrition, genetics, epigenetics, microbiome, biostatistics and bioinformatics.

These authors are united in their concerns on the same scientific question – how do genomic events modify the effects of traditional, environmental risk factors on disease risk? This book offers an expert overview of the advances in the field of gene-environment interactions on human diseases and the cutting-edge methods used to detect the interactions. The majority of the chapters provide detailed up-to-date descriptions of the major findings of gene-environment interactions on various chronic diseases and risk factors such as obesity, lipids, diabetes, cardiovascular disease, cancer, multiple sclerosis, pancreatitis, Parkinson’s disease, and longevity. The book also covers the potential influence of epigenetic events and microbiome on the relation between environment and diseases. In addition, the book also captures the potential application of the findings from this field in personalized prevention and treatment of human diseases.
(Imprint: Nova)

Preface

Chapter 1
Genome, Environment, and Human Diseases
(Lu Qi, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA, and others)

Chapter 2
Are Humans Getting Fitter, Sicker, Neither, or Both?
(Greg Gibson and Alec Nabb, School of Biology, Georgia Institute of Technology, Georgia, USA)

Chapter 3
Study Design and Analysis Considerations in Genome-Wide Studies of Gene-Environment Interactions
(Joanna M. Biernacka, Joseph Usset, Brooke L. Fridley, Stacey J Winham, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA, and others)

Chapter 4
Gene-Environment Interaction and Obesity
(Lu Qi, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA, and others)

Chapter 5
Gene-Environment Interactions on Lipids
(Dolores Corella, Genetic and Molecular Epidemiology Unit. Department of Preventive Medicine and Public Health. University of Valencia and CIBER OBN, Valencia, Spain)

Chapter 6
Gene-Environment Interactions on Type 2 Diabetes
(Min Xu, and Lu Qi, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA, and others)

Chapter 7
Cancer Health Disparities: Contributions from Tumor Biology and Gene-Environment Interactions
(Tiffany A. Wallace and Stefan Ambs, Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA)

Chapter 8
The Missing Heritability in Coronary Artery Disease
(Pierre A. Zalloua, and Daniel E. Platt, Lebanese American University, Lebanon)

Chapter 9
Recent Advances in the Exploration of Gene-Environment Interactions in Parkinson’s Disease
(Jason R. Cannon, Assistant Professor of Health Sciences and Toxicology, Purdue University, West Lafayette, Indiana, USA)

Chapter 10
Gene-Environment Interactions in Multiple Sclerosis
(Roberto Alvarez-Lafuente, Servicio de Neurología. Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid. Spain)

Chapter 11
The Role of Gene-Environment Interactions in Pancreatitis
(Li-Zsa Tan, Chee Yee Ooi, Department of Gastroenterology, Sydney Children’s Hospital, Randwick, NSW Australia, and others)

Chapter 12
Genetics and Gene-Environment Interactions on Longevity and Lifespan
(Chao-Qiang Lai, Yiyi Ma, Laurence D Parnell, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA, and others)

Chapter 13
Gene-Environment Interaction in Origins of Chronic Non-Communicable Disease
(Roya Kelishadi, Parinaz Poursafa, Professor of Pediatrics, Faculty of Medicine and Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran, and others)

Chapter 14
Global DNA Methylation in Obesity, Diabetes, and Cardiovascular Diseases and Influence of environmental factors
(Garcia-Lacarte M, Milagro FI, Martinez JA, Department of Nutrition, Food Science and Physiology and the Centre for Nutrition Research, University of Navarra, Pamplona, Spain, and others)

Chapter 15
Microbiome and Human Health
(Naima G. Cortes-Perez and Luis G. Bermúdez-Humarán, INRA, Immuno-Allergie Alimentaire, CEA/IBiTeC-S/SPI, CEA de Saclay, Gif-sur-Yvette, France, and others)

Chapter 16
The Role of Genomics in Personalised Health Management
(Denis C. Bauer, CSIRO Preventative Health Flagship and CSIRO Computational Informatics, Sydney, NSW, Australia)

Index

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