Gastrointestinal Cancers: Prevention, Detection and Treatment. Volume 1


Amit Kumar Tyagi and Sahdeo Prasad (Editors)
Department of Experimental Therapeutics, The University of Texas MD Anderson Center, Houston, TX, USA

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

Gastrointestinal cancer is the most frequently diagnosed type of cancer worldwide. Gastrointestinal cancer is the cancer of different organs within the digestive system, including the esophagus, stomach, liver, gallbladder, pancreas, small intestine, large intestine, rectum and anus. The common cause of gastrointestinal cancer may be a microbial infection, smoking, alcohol consumption, highly fatty foods, age, race, genetic pattern and geographical location. Gastrointestinal cancer accounts more than 20 percent of all newly diagnosed cancer cases in the United States, where gastric cancer is the fourth-most-common type of cancer and the second-highest cause of cancer deaths. Pancreatic cancer is also a very lethal cancer, and its symptoms appear when the cancer is in its advanced stages. Other gastrointestinal cancers including liver (hepatic), gallbladder, and colorectal cancer; these types of cancer have received considerable attention due to their rising incidences in last few decades. Some other gastrointestinal cancers are not very common and usually associated with cancer of respective organs such as esophageal cancer, cholangiocarcinoma or bile duct cancer, carcinoid tumor, pancreatic islet cell cancer, and duodenal cancer. This book provides a summary of the past, present and future of gastrointestinal cancer history. In this book, numerous international experts of gastrointestinal cancer are discussed, where authors have provided a complete view of the most common and widely used diagnostic methods. Additionally, the authors also explain the unusual techniques and the most innovative complementary methods not yet used in clinical practice. Contributors have also described the latest findings and the various clinical manifestations related to gastrointestinal cancer prevention and treatment. It covers numerous discoveries and inventions in the field of gastrointestinal cancer detection and analysis. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1. Novel Roles of Gut Microbiome in Gastrointestinal Cancer
Barbara Jung and Jun Sun (Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA)

Chapter 2. Endoscopy in the Diagnosis and Management of Oesophagogastric Cancer and Pre-Malignant Lesions
Matthew R Bedford and Ewen A Griffiths (University Hospitals Birmingham NHS Foundation Trust, Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK)

Chapter 3. Surgical Management of Esophageal and Gastroesophageal Junction Tumors
Jacqueline Oxenberg (Geisinger Wyoming Valley, Wilkes-Barre, PA, USA)

Chapter 4. Gastrointestinal Stromal Tumors: Diagnosis and Current Management
Chaya Shwaartz and Celia M. Divino (Division of General Surgery, Department of Surgery, Center for Carcinoid and Neuroendocrine Tumors, Icahn School of Medicine, The Mount Sinai Medical Center, New York, NY, USA)

Chapter 5. Re-Evaluation of the Rational Extent Lymphadenectomy for Local Advanced Gastric Cancer
Han Liang and Jing Yu Deng (Gastric Cancer Surgical Department, Tianjin Medical University Cancer Institute & Hospital, National Clinic Research for Cancer, Tianjin, China)

Chapter 6. New Strategies for Treatment and Prevention of Colorectal Cancer
J.A. Uranga, J.C. Cámara, E. Herradón, G. Vera, N. Jagerovic, E. Quesada, J. Fernández, F. Lombó, R. Abalo (Área de Histología y Anatomía Patológica, Depto. de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos (URJC), Madrid, Spain, and others)

Chapter 7. Management of Locally Advanced Rectal Cancers
Nishi Kothari and Richard Kim (Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, FL, USA)

Chapter 8. Prevention of Colitis-Associated Cancer: From Bench to Bedside
Yoon Jae Kim, Jong Min Park, Young Min Han, Ho Jae Lee, and Ki Baik Hahm (Digestive Disease center, Gachon University Gil Medical Center, Incheon, Korea, and others)

Chapter 9. Rectal Adenocarcinoma
Jennifer W. Harris, Katrina A. Winkler and Jitesh A. Patel (University of Kentucky, Department of Surgery, Lexington, KY, USA)

Chapter 10. Epidemiology and Genetics of Colorectal Cancer
Junxiao Zhang, Jia Che, Xiangling Yang, Xiaoyan Wang, Chenliang Wang, Chuangyu Wen, and Huanliang Liu (Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, and others)

Chapter 11. Early Gastrointestinal Cancer Endoscopic Diagnosis and Treatment
Miguel A. Tanimoto (Gastroenterology Outpatient Clinic Coordinator, National Institute of Medical Sciences and Nutrition “Salvador Zubiran”, Mexico City, Mexico)

Chapter 12. Insights into Metalloproteinases Regulation in Gastrointestinal Cancers: Epigenetic Influences
Sugreev Verma, Sucheta Tripathy, Santanu Raychaudhuri, and Snehasikta Swarnakar (CSIR-Indian Institute of Chemical Biology, Kolkata, India, and others)

Chapter 13. Advances towards a Miniaturized Optical System for Gastrointestinal Cancer Detection Using Diffuse Reflectance and Fluorescence Spectroscopies
Sara Pimenta, Susana Cardoso, Elisabete M. S. Castanheira, Graça Minas (Centre for Microelectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, Guimarães, Portugal, and others)

Chapter 14. Immunotherapy in Gastro-Intestinal Cancers
Marwan Ghosn, Samer Tabchi and Hampig Raphael Kourie (Hematology-oncology department, Faculty of medicine, Saint Joseph University, Beirut, Lebanon)

Chapter 15. Gastrointestinal Stromal Tumors (GIST): Contemporary Insight of Frequency, Diagnosis, Risk Stratification and Management
Hassan Al-Thani, Ahammed Meddodathil, Ayman El-Menyar, Maryam Al-Sulaiti, Abdelhakeem Tabeb, Mohammed Asim, and Rifat Latifi (Department of Surgery, Hamad Medical Corporation, Doha, Qatar, and others)


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