Gasdermin Superfamily: A Novel Gene Family Functioning in Epithelial Cells

Norihisa Saeki and Hiroki Sasaki
National Cancer Center Research Institute, Tokyo, Japan

Series: Cell Biology Research Progress, Genetics – Research and Issues
BISAC: SCI017000

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The Gasdermin Superfamily is a novel gene group consisting of Gasdermin Family genes (GSDMA, GSDMB, GSDMC and GSDMD in humans) and Gasdermin-related genes (DFNA5 and DFNB59 in humans). The members of the Superfamily are expressed in the epithelial cells of a variable type of tissue and may have a differentiation-status specific role; however, their actual functions remain unknown. In this book, the current status of studies on the Superfamily genes is overviewed and their biological importance is discussed. (Imprint: Nova)

Abstract

Introduction

Discovery of Gasdermin Family Genes

Tissue-Specific Expression of Gasdermin Family Genes

Distinct Expression Pattern of Gasdermin Family Genes in Epithelial Differentiation

Gasdermin-Related Genes

The Superfamily Genes and Diseases

Function of the Gasdermin Superfamily Genes

Phylogenetic Analysis of the Gasdermin Superfamily

Conclusion and Future

References

Index

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