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Norihisa Saeki and Hiroki Sasaki
National Cancer Center Research Institute, Tokyo, Japan
Series: Cell Biology Research Progress, Genetics – Research and Issues
BISAC: SCI017000
The Gasdermin Superfamily is a novel gene group consisting of Gasdermin Family genes (GSDMA, GSDMB, GSDMC and GSDMD in humans) and Gasdermin-related genes (DFNA5 and DFNB59 in humans). The members of the Superfamily are expressed in the epithelial cells of a variable type of tissue and may have a differentiation-status specific role; however, their actual functions remain unknown. In this book, the current status of studies on the Superfamily genes is overviewed and their biological importance is discussed. (Imprint: Nova)
Table of Contents
Abstract
Introduction
Discovery of Gasdermin Family Genes
Tissue-Specific Expression of Gasdermin Family Genes
Distinct Expression Pattern of Gasdermin Family Genes in Epithelial Differentiation
Gasdermin-Related Genes
The Superfamily Genes and Diseases
Function of the Gasdermin Superfamily Genes
Phylogenetic Analysis of the Gasdermin Superfamily
Conclusion and Future
References
Index
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