Gamma-Aminobutyric Acid (GABA): Biosynthesis, Medicinal Uses and Health Effects

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Josipa Vlainic, PhD and Maja Jazvinscak Jembrek, PhD (Editors)
Laboratory of Molecular Neuropharmacology, Division of Molecular Medicine, Rudjer Boskovic Institute, Croatia

Series: Neuroscience Research Progress
BISAC: SCI089000

Gamma-amino butyric acid (GABA) is a ubiquitous non protein amino acid which exerts various functions in different mammalian tissues and other organisms (e.g. bacteria, plants, fungi). Beyond its most investigated function as an inhibitory neurotransmitter in the mammalian brain, GABA has a role as a hormone or trophic factor in non-neuronal peripheral and endocrine systems.

Other effects of GABA include hypotensive, tranquilizing, diuretic and antidiabetic activity. In this book, several topics regarding GABA are covered, starting from its synthesis and transport. This book provides important and novel information on the topic from some of the most prominent scientists in the field. (Imprint: Nova)

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Table of Contents

Table of Contents

Preface

Chapter 1 – Regulation of GABA Synthesis and Transport (pp. 1-12)
Jigar Pravinchandra Modi, Howard Prentice and Jang-Yen Wu (College of Medicine, Florida Atlantic University, FL, US and others)

Chapter 2 – GABA Metabolism in Saccharomyces cerevisiae (pp. 13-28)
Susana Correa-García and Mariana Bermúdez-Moretti (Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires – IQUIBICEN, CONICET, Argentina)

Chapter 3 – The Effects of Persistent Activation of GABAA Receptors by Neurotransmitter GABA (pp. 29-48)
Josipa Vlainić, Dubravka Švob Štrac and Maja Jazvinšćak Jembrek (Rudjer Boskovic Institute, Department of Molecular Medicine, Laboratory of Molecular Neuropharmacology, Zagreb, Croatia)

Chapter 4 – The Role of GABA in Development and Behaviour: Emphasis on the Effects of GABA Receptor Agonists and Antagonists (pp. 49-70)
Maja Jazvinšćak Jembrek, Josipa Vlainić and Vedrana Radovanović (Laboratory for Molecular Neuropharmacology, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia)

Chapter 5 – The Effects of GABA and GABAergic Drugs on the HPA Axis Activity (pp. 71-92)
Dubravka Svob Strac, Dorotea Muck-Seler and Nela Pivac (Rudjer Boskovic Institute, Division of Molecular Medicine, Zagreb, Croatia)

Chapter 6 – GABAergic Drugs in the Treatment of Cerebellar Ataxia and Other Motor Disorders of the Central Nervous System (pp. 93-108)
José Gazulla, Carlota Ruiz-Gazulla and María Tintoré (Department of Neurology, Hospital Universitario Miguel Servet. Zaragoza; Faculty of Science, University of Zaragoza, and Nucleic Acid Chemistry, Institute for Advanced Chemistry of Catalonia, Barcelona CSIC, Spain)

Chapter 7 – GABA-Mediated over-Inhibition in Down Syndrome: Implications for Cognitive and Neuromorphological Phenotypes (pp. 109-132)
Paula Martínez and Carmen Martínez-Cué (Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain)

Chapter 8 – Behavioral and Psychological Symptoms of Dementia and GABAergic System: Implications for Treatment (pp. 133-158)
Maite Solas and Maria J. Ramirez (Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain)

Chapter 9 – GABAergic System and Alzheimer’s Disease (pp. 159-180)
Claudio De Piazza (Neurology Unit, Valduce Hospital, Como, Italy)

Chapter 10 – GABA Pharmacology in Veterinary Medicine: From Anesthesia to Phobias Treatment (pp. 181-196)
Jelena Šuran and Josipa Vlainić (Department of Pharmacology and Toxicology, Faculty of Veterinary medicine, University of Zagreb, Croatia)

Index

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