Fibronectin: Current Concepts in Structure, Function and Pathology


James Beattie (Editor)
University of Leeds, Department of Medicine, Irvine, Ayrshire, UK

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: MED008000

The multidomain extracellular protein fibronectin (Fn) is assuming an increasingly important role in cell biology. Interactions between Fn and juxtaposed cells play an important role in the regulation of cell migration, adhesion, growth, differentiation and apoptosis. This classical “outside-in” signalling leads to the activation of intra-cellular signalling pathways and results in the transient formation of protein-protein complexes and alterations in the states of protein phosphorylation which ultimately lead to changes in gene expression. The role of Fn in the aetiogy and regulation of different disease processes is an increasingly popular research area. The role of Fn in the establishment and spread of tumour cells is one such topic. This book draws on the expertise of many laboratories to provide up to date research findings for those interested in this field. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Chapter 1 – Fibronectin functions: mechanisms and applications
(M F Beaux II, N H Kwon, P Sharma, MPA Division, Los Alamos National Laboratory, Los Alamos, NM, USA and others)

Chapter 2 – FN modulation of growth factor activity
(James Beattie, Dept of Oral Biology Leeds Dental Institute, Clarendon Way University of Leeds, Leeds LS2 9LU)

Chapter 3 – Fibronectin: the N-terminal region and its role in cell migration- implications for disease and healing
(Ian R Ellis, Mohammad R Islam, Lateef E. Aljorani, Sarah J Jones. Unit of Cell and Molecular Biology, Dundee Dental School, University of Dundee, Park Place, Dundee. DD1 4HN)

Chapter 4 – Fibronectin assembly and function: A multi-dimensional view
(Wing S. To and Kim S. Midwood, Kennedy Institute of Rheumatology, Imperial College, London)

Chapter 5 – Vesicular Trafficking of the Fibronectin Receptor alpha5β1 Integrin
(Chuan Hu, Nazarul Hasan and Krista A. Riggs, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY, USA)

Chapter 6 – Methods to Study Fibronectin Secretion and Matrix Assembly by Fibroblasts In Vitro and In Vivo
(Anna Goc, Maha Abdalla, and Payaningal R. Somanath, Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, GA, USA and others)

Chapter 7 – Pathways Regulating Secretion and Assembly of Fibronectin Matrix: An Update
(Maha Abdalla, Anna Goc and Payaninga R. Somanath, Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, GA, USA and others)

Chapter 8 – Modulation of fibronectin expression in astrocytes affects neuritogenesis: relevance in developmental neurotoxicity
(Lucio G. Costa1, Marina Guizzetti, Daniella Pizzurro and Gennaro Giordano, Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA and others)

Chapter 9 – Evidence for fibronectin role on uterine Natural Killer cells migration, proliferation, differentiation and survival during pregnancy
(Bruno Zavan, Andréa Mollica do Amarante Paffaro, Paulo P.Joazeiro, Áureo.T.Yamada, Valdemar A. Paffaro Jr, Integrative Biology Laboratory-LABAint. Biomedical Science Institute. UNIFAL-MG. Alfenas. MG. Brazil and others)

Chapter 10 – Fibronectin: Structure, Biosynthesis and Roles in Disease
(Kátia da Silva Calabrese, Luiz Otávio Pereira Carvalho, Tania Zaverucha do Valle, Flávia de Oliveira Cardoso and Ana Lúcia Abreu-Silva, Instituto Oswaldo Cruz)

Chapter 11- Fibronectin in Renal Diseases and Peritoneal Dialysis
(Susan Yung and Tak Mao Chan Department of Medicine, University of Hong Kong, Hong Kong Queen Mary Hospital, Hong Kong)

Chapter 12 – Role of fibronectin in tissue remodeling during chronic kidney disease development
(Sein O’Connell, Stephen Nolan, Craig Slattery, Michael P Ryan and Tara McMorrow, Renal Disease Research Group UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland)

Chapter 13 – Roles of Fibronectin in Neoplasm
(Zhenggang Xiong and Liqiong Liu, Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, Tulane New Orleans, LA, USA, Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center, Perdido Street, New Orleans, LA, USA)

Chapter 14 – Fibronectin and brain tumors
(Mariella Caffo,, Gerardo Caruso, Valeria Barresi, Marcello Passalacqua, Filippo Flavio Angileri and Francesco Tomasello, Neurosurgical Clinic, Department of Neuroscience, Department of Human Pathology, School of Medicine, University of Messina, Italy)



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