Extracellular Vesicles: Mechanisms and Role in Health and Disease


Juanita F. Lafon (Editor)

Series: Cell Biology Research Progress
BISAC: SCI017000

Extracellular vesicles are small vesicles (or membrane-bound organelles) that can be found in blood and other biofluids and their internal content and surface reflect their origin and potential function. Extracellular Vesicles: Mechanisms and Role in Health and Disease begins with a summary of the most recent findings about the potential role of extracellular vesicles in human health and diseases and discusses future directions.

The authors discuss how intercellular communication at the developing feto-maternal interface is of cardinal interest. The implantation itself is at least partially-dependent on extracellular vesicles’ mediated processes. Furthermore, the altered local and systemic immunomodulatory state seems to be significantly influenced by proteomic and nucleic acid cargo found in extracellular vesicles.

Lastly, recent studies in the development of metastatic potential are studied by focusing on the role of oxidative stress under the control of reprogrammed onco-metabolism using the LNCaP-C4-2B prostate cancer progression model system.
(Imprint: Nova Medicine and Health)

Table of Contents

Table of Contents


Chapter 1. Extracellular Vesicles in Physiological and Pathological Conditions in Humans
(Diddier Prada, Anahí Medina, Rodosthenis Rodosthenous, Andrea Baccarelli, Mahuina Campos and Luis A. Herrera, Biomedical Research Unit in Cancer, Instituto Nacional de Cancerología, Instituto de Investigaciones Biomédicas, Mexico City, Mexico, and others)

Chapter 2. Current Trends on Exploring the Multifaceted Role of Extracellular Vesicles in Human Pregnancy
(Árpád Ferenc Kovács, MD, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, and others)

Chapter 3. Onco-Metabolism Driving Large Extracellular Vesicle (LEV) Biogenesis in Castration Resistant Prostate Cancer Metastasis
(Thambi Dorai, Ankeeta Shah, Faith Summers, Rajamma Mathew, Jing Huang, Tze-chen Hsieh and Joseph M. Wu, Department of Urology, New York Medical College, Valhalla, NY, USA, and others)


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