Experimental Organ Transplantation

Huifang Chen, MD, PhD (Editor)
Department of Surgery, Faculty of Medicine, Research Center, CHUM, Notre-Dame Hospital, CHUM, University of Montreal, Montreal, Canada

Shiguang Qian, MD, MSc (Editor)
Associate Professor of Immunology Surgery, Department of Immunology, Lerner Research Institute, Department of General Surgery, Transplant Centre, Digestive Disease Institute, Cleveland. OH, USA

Series: Organ Transplantation Research Horizons, Surgery – Procedures, Complications, and Results
BISAC: MED085070

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Organ transplantation is one of the best therapeutic options for patients with end-stage organ failure. Experimental organ transplantation is an important link between basic science and clinical practice. Both editors, Dr. Chen and Dr. Qian, have been working in this area for more than 20 years. Experts from the United States, Canada, China, Japan, Italy, Spain, Turkey, Switzerland, Hungary, and Brazil contributed 25 chapters in this book, and provided detailed descriptions of techniques for vascularized organ allografts in mice, rats, pigs, and nonhuman primates, as well as detailed descriptions of non-vascularized pancreatic islet and spleen allografts.

Furthermore, they discussed new advances in transplantation immunology. This book provides numerous important references which were carefully selected by the authors to extend their visions and knowledge. The appropriate readers of this book include medical students, graduate students, residents, surgeons, physicians and immunologists interested in the transplantation area. (Imprint: Nova Biomedical )

Foreword

Preface

SECTION I. TRANSPLANTATION MODELS IN RODENTS, PIGS, AND NONHUMAN PRIMATES

Chapter 1. Applications of Experimental Transplantation in Medical Research
(Huifang Chen and Pierre Daloze, University of Montreal, Canada)

Chapter 2. Heterotopic Heart Transplantation in Mice
(Hao Dun and Huifang Chen, University of Montreal, Canada)

Chapter 3. Kidney Transplantation in Mice
(Zheng Zhang, Jiao-Jing Wang, Xueqiong Wang and Jing Han, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, and others)
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Chapter 4. Liver Transplantation in Mice
(Yinghua Tian and Shiguang Qian, Department of Visceral and Transplantation Surgery, University Hospital of Zürich, Zürich, Switzerland, and others)

Chapter 5. Pancreatic Islet Transplantation in Mice
(Ronghai Deng, Paul Schroder and Wenhao Chen, University of Toledo, College of Medicine, Toledo, OH, USA, and others)

Chapter 6. Small Bowel Transplantation in Mice
(Fengchun Liu and Sang-Mo Kang, Division of Surgery, Transplant Division, University of California, San Francisco, CA, USA)

Chapter 7. Spleen Autotransplantation in Mice
(Iren Miko, Norbert Nemeth and Istvan Furka, Department of Operative Techniques and Surgical Research, Institute of Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary)

Chapter 8. Limb Transplantation in Mice Induction of Limb Allograft Tolerance in Mice: Clinical Course and Pathology Studies
(Hao Wang, Zhixiang Zhang, Jifu Jiang and Toni Zhong, University of Western Ontario, Canada, and others)

Chapter 9. Heterotopic Heart Transplantation in Rats
(Yanxin Hu and Huifang Chen, University of Montreal, Canada)

Chapter 10. Kidney Transplantation in Rats
(Paulo N. Martins, Massachusetts General Hospital, Dept. of Surgery, Division of Transplantation, Harvard Medical School, Boston, MA, USA)

Chapter 11. Lung Transplantation in Rats
(Tomohiro Kawamura, Yugo Tanaka, Norisha Shigemura, Yoshiya Toyoda and Atsunori Nakao, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA, and others)

Chapter 12. Pancreaticoduodenal Transplantation in Rats
(Antonio Di Cataldo, Giovanni Li Destri, Raffaele Lanteri and Stefano Puleo, Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, Italy)

Chapter 13. Orthotopic Liver Transplantation in Rats
(Shintaro Yagi, Shinji Uemoto and Eiji Kobayashi, Department of Hepatobiliary, Pancreas and Transplant Surgery, Kyoto University, Kyoto, Japan and others)

Chapter 14. Small Intestine Transplantation in Rats
(Atsunori Nakao, Timothy R. Billiar and Eiji Kobayashi, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA and others)

Chapter 15. Testicle Transplantation in Rats
(Kupa Bilolo and Huifang Chen, University of Montreal, Canada)

Chapter 16. Face Transplantation in Rats
(Maria Siemionow and Fatih Zor, Department of Plastic Surgery, Cleveland Clinic, OH, USA, and others)

Chapter 17. Ovary Transplantation in Rats
(Kupa Bilolo, Edna Frasson de Souza Montero, Yanxin Hu, Anlun Ma and Huifang Chen, Laboratory of Experimental Surgery, Notre-Dame Hospital, Department of Surgery, Research Center, Centre Hopsitalier de l’Université de Montréal (CRCHUM), University of Montreal, Québec, Canada, and others)

Chapter 18. Liver Transplantation in Pigs
(Paulo N. Martins, James F. Markmann and Martin Hertl, Department of Surgery, Transplant Division, Massachusetts General Hospital, Harvard University, Boston, MA, USA)

Chapter 19. Kidney Transplantation in Nonhuman Primates
(Lijun Song and Huifang Chen, University of Montreal, Canada)

SECTION II. IMMUNOLOGY ISSUES IN TRANSPLANTATION

Chapter 20. T Cell and B Cell Responses in Transplantation
(Paul Schroder, Ronghai Deng and Wenhao Chen, University of Toledo, College of Medicine, Toledo, OH, USA, and others)

Chapter 21. Innate Immunity in Transplantation
(Xian C. Li and Xiaoshun He, Harvard Medical School, Transplantation Research Center, Brigham and Women’s Hospital & Children’s Hospital, Boston, MA, USA, and others)

Chapter 22. Dendritic Cells in Transplantation Tolerance
(Sumantha Bhatt, Shiguang Qian and Lina Lu, Department of Immunology, Lerner Research Institute, and Department of General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, OH, USA)

Chapter 23. Regulatory T Cells in Transplantation
(José A, Pons, Beatriz Revilla-Nuin, Alberto Baroja-Mazo, Pablo Ramírez and Pascual Parrilla, Liver Transplant Unit, University Hospital “Virgen de la Arrixaca”, Murcia, Spain)

Chapter 24. Stem Cells in Tissue and Organ Transplantation
(Mathilde Soulez, Mélanie Dieudé and Marie-Josée Hébert, Notre-Dame Hospital, University of Montreal, Canada)

Chapter 25. New Generation of Immunosuppressants
(Kupa Bilolo, Yanxin Hu, Anlun Ma and Huifang Chen, University of Montreal, Canada)

Index

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