Exosomes: Biogenesis, Therapeutic Applications and Emerging Research

Armando Meyer (Editor)

Series: Cell Biology Research Progress
BISAC: SCI017000

Exosomes are small (30-100 nm diameter) membrane enclosed vesicles of endosomal origin, released by a variety of cell types, which are capable of transferring biologically active macromolecules, such as proteins, lipids and RNA to other cells. Therefore, exosomes are important mediators of intercellular communication influencing physiological or pathological processes at recipient cells. In this book, Chapter One briefly reviews the knowledge gained on the molecular mechanisms underlying exosome formation and release. Chapter Two studies whether the Extracellular Vesicle (EV) Array can be utilized to phenotype unpurified small EVs (sEVs) from other body fluids such as urine, saliva, synovial fluid, cerebrospinal fluid (CSF), ascites, bone marrow (BM) and bronchoalveolar lavage fluid (BALF). Chapter Three examines the multifaceted roles of tumor-associated exosomes in the development and progression of cancer as well as the unique utility they present to detect, monitor, and therapeutically combat tumor occurrences. Chapter Four provides a review of the types of EVs encountered by sperm in the environment they traverse on their journey to the ampulla in the oviduct. (Imprint: Nova Biomedical)




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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Table of Contents


Chapter 1. Molecular Mechanisms of Exosome Biogenesis
Mara E. da Silva-Januário, Yunan C. Januário, Julianne V. de Carvalho, and Luis L. P. daSilva (Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil)

Chapter 2. Phenotyping of Small Extracellular Vesicles from Clinically Important Body Fluids using Protein Microarray
M. M. Jørgensen, R. Bæk, S. Tveito, B. Schmeck, T. Greulich, A. Stensballe, and K. Varming (Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, and others)

Chapter 3. Exosomes: Mediators of Cell-Cell Communication and Potential Biomarkers in Cancer
Jennifer Crow, Glenson Samuel, Safinur Atay, and Andrew K. Godwin (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA, and others)

Chapter 4. Extracellular Vesicles in the Reproductive Tracts: Roles in Sperm Maturation and Function
Patricia A. Martin-DeLeon (Department of Biological Sciences, University of Delaware, USA)



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