Excitotoxicity: Fundamental Concepts, Pathophysiology and Treatment Strategies

Emerson D. Metzger (Editor)
Keith G. Halsey (Editor)

Series: Neuroscience Research Progress
BISAC: MED057000



Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Excitotoxicity is the pathological process in which neurons are damaged and killed by overstimulation of the excitatory neurotransmitter glutamate receptors. Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity) and in neurodegenerative diseases of the central nervous system (CNS) such as multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, alcoholism or alcohol withdrawal and especially benzodiazepine withdrawal, and also Huntington’s disease.

In this book, the authors discuss the fundamental concepts, pathophysiology and treatment strategies of excitotoxicity. Topics include the involvement of glutamate excitotoxicity in Parkinson’s disease; the relevance of the excitotoxic process to schizophrenia; the role of glial cells during the regenerative process and possible strategies of treatment to avoid neuronal damage; and an overview of the current concepts related to the intermittent-hypoxia-induced excitotoxicity in obstructive sleep apnea (OSA) disease. (Imprint: Nova Biomedical )


Dissecting Involvement of Glutamate Excitotoxicity in Parkinson’s Disease
(Michael F. Salvatore, Tanya Chotibut, Jennifer Arnold, Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA)

Excitotoxicity and Schizophrenia
(Jacqueline Conway, Independent Mental Health Researcher, London, UK)

Glial Cells on Microenvironment of Motoneurons: An Important Insight for Understanding the Mechanisms that Limit Neuronal Damage
(C.M. Freria, S.C. Victorio, Department of Neuroscience, Ohio State University, Columbus, Ohio, USA, and others)

Excitotoxicity in Obstructive Sleep Apnea Disease
(Robert Brevetta, Madalina Macrea, Virginia Tech, Carilion School of Medicine, Roanoke, Virginia, USA, and others)


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