Estradiol: Synthesis, Health Effects and Drug Interactions

Ricco Palmeri (Editor)
Sal Grimaudo (Editor)

Series: Endocrinology Research and Clinical Developments
BISAC: MED082000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Estradiol is the major steroid hormone which is involved in several organic functions, such as physiological sexual behavior, development and maintenance of male and female reproductive organs, control of visceral secretion, modulation of immune system, and tumorigenesis. In this compilation, the authors discuss the synthesis, health effects and drug interactions of estradiol. Topics include the occurrence of estradiol in environmental waters; estradiol in the central nervous system and its role in neurodegeneration; the effects of estradiol on male and female reproductive tissues and the influence of endocrine disruptors; estradiol and prostate cancer; hydroxyestradiols and methoxyestradiols as endogenous factors associated to physiological and physiopathological conditions; estrogen and functional gastrointestinal disorders; estradiol and memory; estradiol in the environment; use of combined therapy of estrogens with antidepressants; estrogen and nitric oxide as a treatment for diabetes gastroparesis; estradiol synthesis after ovarian tissue cryopreservation and transplantation; estradiol-mediated overmodulation of the neuroendocrine hormone dopamine is central to the pathophysiology of restless leg syndrome during pregnancy; and estrogen modulation on oxidative stress and synaptic plasticity in the dorsal hippocampus. (Imprint: Nova Biomedical )


Occurrence of Estradiol in Environmental Waters
(Valentina F. Domingues, Virgínia C. Fernandes, Luísa Correia-Sá, Catarina Mansilha, REQUIMTE, Instituto Superior de Engenharia, Instituto Politécnico do Porto, Porto, Portugal, and others)

Estradiol in CNS: Role in Neurodegeneration
(M.J. Pérez-Álvarez, F. Wandosell, Departamento de Biología (Fisiología Animal), Univ. Autónoma de Madrid, Madrid, Spain, and others)

Effects of Estradiol on Male and Female Reproductive Tissues and the Influence of Endocrine Disruptors
(Luiz Gustavo de Almeida Chuffa, Beatriz Aparecida Fioruci-Fontanelli, Elaine Manoela Porto-Amorim, João Paulo de Arruda Amorim, Department of Anatomy - IBB/UNESP – Univ Estadual Paulista, SP, Brazil, and others)

Estrogens and Prostate Cancer: From Biosynthesis to Physiological Effects
(Inês M. Gomes, Cátia V. Vaz, Daniel B. Rodrigues, Sandra M. Rocha, Sílvia Socorro, Cecília R. Santos, Cláudio J. Maia, CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Portugal)

Hydroxyestradiols and Methoxyestradiols as Endogenous Factors Associated to Physiological and Physiopathological Conditions
(Alexis Parada-Bustamante, Pedro A. Orihuela, Cristián Molina, Hugo Cardenas, Patricia Reuquén, Cecilia Valencia, Ramiro Rincón, Instituto de Investigaciones Materno-Infantil, Facultad de Medicina, Universidad de Chile, and others)

Estrogen and Functional Gastrointestinal Disorders
(Gengqing Song, Sunny Joseph, M. Showkat Ali, Richard W. McCallum, Department of Internal Medicine, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA, and others)

Estradiol and Memory: Morphological and Behavioural Implications
(Brianne C. Wartman, Matthew R. Holahan, Carleton University, Department of Neuroscience, Ottawa, Ontario, Canada)

Estradiol in the Environment: Analysis and Occurrence
(J.C. Bravo Yagüe, R.M. Garcinuño Martínez, A. Gallego Picó, D. González Gómez, P. Fernández Hernando, J.S. Durand Alegría, GTyMAQ Research Group, Department of Analytical Sciences, Faculty of Sciences, UNED, Madrid, Spain)

Use of Combined Therapy of Estrogens with Antidepressants for Depressive Disorders: A Preclinical Review
Erika Estrada-Camarena, Silvia Mejía-Mauries, Nelly Maritza Vega-Rivera, Alfredo Gallardo-Tenorio, Alonso Fernández-Guasti, Laboratory of Neuropsychopharmacology, Direction of Neurosciences, National Institute of Psychiatry, México, D.F., Mexico, and others)

Estrogen and Nitric Oxide are the New Players in Diabetes Gastroparesis
(M. Showkat Ali, Rebecca Smiley, Kerry Preston, Gengqing Song, Richard Mccallum, Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, TX, USA, and others)

Estradiol Synthesis after Ovarian Tissue Cryopreservation and Transplantation
(Sanghoon Lee, Seung Yup Ku, Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea, and others)

Estradiol-Mediated Overmodulation of the Neuroendocrine Hormone Dopamine is Central to the Pathophysiology of Restless Legs Syndrome during Pregnancy
(Jose Carlos Pereira Jr., Ingrid Ramos Rocha e Silva, Marcia Pradella-Hallinan, Faculdade de Medicina de Jundiaí, Jundiaí, São Paulo, Brazil, and others)

Estrogen Modulation on Oxidative Stress and Synaptic Plasticity in the Dorsal Hippocampus
(V. Beltrán-Campos, E. Gómez-Padilla, G.I. Medina-Aguirre, S.A. Castro-Chavira, S. Díaz-Cintra)


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