Essential Guide to Clinical Neonatology

Jeanette D. Hoenig, M.D. (Editor)
Section of Neonatology, Director of Quality Improvement, Director of Pediatric Resident Research, Chicago, IL, USA
Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, US

Alison Chu, M.D. (Editor)
Assistant Professor-in-Residence, UCLA David Geffen
School of Medicine, Division of Neonatology & Developmental Biology,
Department of Pediatrics, Los Angeles, CA, US

Joseph R. Hageman, M.D. (Editor)
Director NICU Quality Improvement, Comer Children’s Hospital, Senior Clinician Educator, Pritzker School of Medicine, University of Chicago, Chicago, IL., US

Series: Pediatrics – Laboratory and Clinical Research
BISAC: MED069000

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Essential Guide to Neonatology is the last handbook any neonatal care provider will need, providing a concise yet comprehensive review of essential topics. While it is handbook-sized, it provides in-depth descriptions of fundamental principles for didactic learning, balanced with practical management pointers. It covers common diagnoses in neonatology (from respiratory distress syndrome to congenital cardiac disease to anemia of prematurity), provides procedural guides (such as lumbar puncture and umbilical line placement), and includes nutritional guidelines for neonates, a comprehensive medication dosing guide, and more.

The book is organized by organ systems, and chapters generally provide background didactic information covering basic physiology, diagnostic instruction, as well as management principles based upon evidence-based medicine. Therefore, it can be read from cover to cover to establish a foundation of knowledge for neonatal trainees, or each chapter can be read in isolation as needed for day-to-day practice. Chapters have been authored by a team of multi-disciplinary experts from physicians, to fellows, to respiratory and developmental therapists, to nutritionists, all of who have been recruited from across the US. Therefore, the content of this handbook is accessible at many levels of experience, across many of the disciplines that are essential for providing well-rounded neonatal care, and for any neonatal intensive care unit – from community NICUs to academic institutions.

This textbook features:
•Reader-friendly tables and figures for quick reference
•Intuitive chapter organization, which provides evidence-based didactic and management information
•A comprehensive range of topics covered, from basic physiology, to ethical issues, to how to write TPN
•Practical medication dosing tables throughout the textbook
•Detailed procedural instruction and rounding tips for trainees (Imprint: Nova Biomedical)

Introduction

Chapter 1. Prenatal Screening, Testing and Fetal Monitoring
Eve Simi and Alicia McCarthy (Genetic Counselor, Insight Medical Genetics, Chicago, IL, USA, and others)

Chapter 2. Antenatal Counseling
Elaine Farrell (Senior Attending Neonatologist, NorthShore University HealthSystem, Senior Clinician Educator, Pritzker School of Medicine
University of Chicago, Chicago, IL, USA)

Chapter 3. Delivery Room Preparation
Jeanette D. Hoenig and Christine O’Malley (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 4. Delivery Room Management
Jeanette D. Hoenig and Christine O’Malley (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 5. NICU Admission Criteria Guidelines
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 6. Admission to the NICU - Initial Steps
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 7. Daily Plan
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 8. NICU Discharge Planning
Bree Andrews (Assistant Professor of Pediatrics, Pritzker School of Medicine, University of Chicago, Section of Neonatology, Comer Children’s Hospital, Chicago, IL, USA)

Chapter 9. Labs, Studies and Screens
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 10. ABC’s of Neonatal Transport
Jeanette D. Hoenig and Jeremy Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 11. Emergencies
Jeanette D. Hoenig and Mario Zaritzky (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 12. Preterm Infant – Overview
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Procedures

Chapter 13. Drawing Blood
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 14. Peripheral Arterial and Venous Catheterization
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 15. Umbilical Arterial Catheterization
Jeanette D. Hoenig and Mario Zaritzky (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 16. Umbilical Venous Catheterization
Jeanette D. Hoenig and Mario Zaritzky (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 17. Endotracheal Intubation
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 18. Chest Tube Insertion
Jeanette D. Hoenig and Mario Zaritzky (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 19. Lumbar Puncture
Jeanette D. Hoenig (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA)

Chapter 20. Pericardiocentesis
Jeanette D. Hoenig and Mario Zaritzky (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 21. Exchange Transfusion
Joanna J. Parga-Belinkie (Neonatal-Perinatal Medicine Fellow, Mattel Children’s Hospital, David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

Chapter 22. Peripherally Inserted Central Catheters (PICCs)
Christine O’Malley (Pediatrics/Neonatology, University of Chicago Medicine-Biological Sciences division, Comer Children's Hospital (Stephen Neonatology Intensive Care Unit), Chicago, IL, USA)

Nutrition

Chapter 23. Principles of Nutritional Support
William MacKendrick and Taylor Peters (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA, and others)

Chapter 24. Parenteral Nutrition
Gina A. Neill and Carol F. Polinski (Neonatal Dietician, Adventist Hinsdale Hospital, Hinsdale, IL, USA, and others)

Chapter 25. Osteopenia of Prematurity
Gina A. Neill (Neonatal Dietician, Adventist Hinsdale Hospital, Hinsdale, IL, USA)

Cardiovascular

Chapter 26. Patent Ductus Arteriosus
William MacKendrick (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA)

Chapter 27. Persistent Pulmonary Hypertension of the Newborn
Sushmita G. Yallapragada (Department of Pediatrics, Division of Neonatology, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA)

Chapter 28. Hypotension
William MacKendrick (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA)

Chapter 29. Extracorporeal Membrane Oxygenation (ECMO)
Joanna J. Parga-Belinkie and Leslie Caldarelli (Neonatal-Perinatal Medicine Fellow, Mattel Children’s Hospital, David Geffen School of Medicine, University of California, Los Angeles, CA, USA, and others)

Chapter 30. Congenital Heart Disease in the NICU
Jennifer Liedel (Assistant Professor, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Division of Pediatric Critical Care, Bronx, NY, USA)

Chapter 31. Congenital Heart Disease: Pre-Operative Management
Jennifer Liedel (Assistant Professor, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Division of Pediatric Critical Care, Bronx, NY, USA)

Chapter 32. The Premature Infant with Congenital Heart Disease
Jennifer Liedel (Assistant Professor, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Division of Pediatric Critical Care, Bronx, NY, USA)

Chapter 33. Additional Evaluation of the Child with Congenital Heart Disease
Jennifer Liedel (Assistant Professor, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Division of Pediatric Critical Care, Bronx, NY, USA)

Pulmonary

Chapter 34. Transient Tachypnea of the Newborn
Eunice Hagen (Department of Pediatrics, Division of Neonatal Medicine, Clinical Assistant Professor of Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital Los Angeles, Los Angeles, CA, USA)

Chapter 35. Meconium Aspiration Syndrome
Jeanette D. Hoenig and Thomas Wiswell (Attending Neonatologist, DuPage Neonatology Associates, Hinsdale, IL, USA, and others)

Chapter 36. Respiratory Distress Syndrome
William MacKendrick (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA)

Chapter 37. Bronchopulmonary Dysplasia
Joseph R. Hageman, Melissa Andrianov and Mario Zaritzky (Senior Clinician Educator, Pritzker School of Medicine, University of Chicago, Section of Neonatology, Department of Pediatrics, Chicago, IL, USA, and others)

Chapter 38. Neonatalogy Oxygen Therapy Guidelines
Sherri Sadler and Joseph R. Hageman (Pediatrics/Neonatology, University of Chicago Medicine-Biological Sciences division, Comer Children's Hospital (Stephen Neonatology Intensive Care Unit), Chicago, IL, USA, and others)

Chapter 39. Management of Ventilation
William MacKendrick, William MacKendrick, Karen Slotarski, and Paula Lussier (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA, and others)

Chapter 40. Neonatal Apnea
Kalpashri Kesavan and Christine Carlos (Assistant Professor, Division of Neonatology and Developmental Biology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA, and others)

Neurology

Chapter 41. Neonatal Seizures
Gaurav Yadava (Pediatric Neurologist, Elmhurst, IL, and Clinical Associate University of Chicago, Chicago, IL, USA)

Chapter 42. Hemorrhagic and Ischemic Brain Injury in the Preterm Infant
William MacKendrick, Joseph R. Hageman and Mario Zaritzky (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA, and others)

Chapter 43. Hypoxic Ischemic Encephalopathy
Kalpashri Kesavan (Assistant Professor, Division of Neonatology and Developmental Biology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA)

Chapter 44. Sedation and Analgesia in Neonates
Kalpashri Kesavan (Assistant Professor, Division of Neonatology and Developmental Biology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA)

Chapter 45. Neonatal Abstinence Syndrome
Kalpashri Kesavan (Assistant Professor, Division of Neonatology and Developmental Biology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA)

Hematology

Chapter 46. Anemia of Prematurity
Gavin D. Roach (Assistant Professor, Division of Pediatric Hematology and Oncology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA)

Chapter 47. Thrombocytopenia
Gavin D. Roach (Assistant Professor, Division of Pediatric Hematology and Oncology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA)

Chapter 48. Leukocyte Abnormalities
Gavin D. Roach (Assistant Professor, Division of Pediatric Hematology and Oncology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA)

Chapter 49. Bilirubin
William MacKendrick (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA)

Endocrinology

Chapter 50. Disorders of Glucose Metabolism
C. Lydia Wraight (Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA)

Chapter 51. Disorders of the Adrenal Gland
C. Lydia Wraight (Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA)

Chapter 52. Disorders of the Thyroid Gland
C. Lydia Wraight (Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA)

Chapter 53. Inborn Errors of Metabolism
C. Lydia Wraight (Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA)

Infectious Disease

Chapter 54. Neonatal Infections
Colleen B. Nash and Dietra D. Millard (Assistant Professor, Department of Pediatrics, Director, Pediatric Antimicrobial Stewardship Program, Rush University Children’s Hospital, Chicago, IL, USA, and others)

Chapter 55. Congenital Infections: Expanded Torch
Colleen B. Nash and Dietra D. Millard (Assistant Professor, Department of Pediatrics, Director, Pediatric Antimicrobial Stewardship Program, Rush University Children’s Hospital, Chicago, IL, USA, and others)

Chapter 56. Maternal Prenatal Infection Screening
Colleen B. Nash and Dietra D. Millard (Assistant Professor, Department of Pediatrics, Director, Pediatric Antimicrobial Stewardship Program, Rush University Children’s Hospital, Chicago, IL, USA, and others)

Chapter 57. Antimicrobial Stewardship in Neonates
Colleen B. Nash and Dietra D. Millard (Assistant Professor, Department of Pediatrics, Director, Pediatric Antimicrobial Stewardship Program, Rush University Children’s Hospital, Chicago, IL, USA, and others)

Chapter 58. Recommendations for Isolation
Colleen B. Nash and Dietra D. Millard (Assistant Professor, Department of Pediatrics, Director, Pediatric Antimicrobial Stewardship Program, Rush University Children’s Hospital, Chicago, IL, USA, and others)

Gastroenterology

Chapter 59. Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in the Neonate
Sherri Sadler (Pediatrics/Neonatology, University of Chicago Medicine-Biological Sciences division, Comer Children's Hospital (Stephen Neonatology Intensive Care Unit), Chicago, IL, USA)

Chapter 60. Necrotizing Enterocolitis
William MacKendrick and Mario Zaritzky (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA, and others)

Chapter 61. Parenteral Nutrition - Associated Liver Disease
Gina A. Neill and Timothy Sentongo (Neonatal Dietician, Adventist Hinsdale Hospital, Hinsdale, IL, USA, and others)

Chapter 62. Newborn Bowel Obstruction
Theodore V. De Beritto and Mario Zaritzky (Resident In Pediatrics, Department of Pediatrics, Comer Children’s Hospital, University of Chicago, Chicago, IL, USA, and others)

Renal

Chapter 63. Renal Development, Function and Selected Disorders
Eunice Hagen (Department of Pediatrics, Division of Neonatal Medicine, Clinical Assistant Professor of Pediatrics, Keck School of Medicine
University of Southern California, Children's Hospital Los Angeles, Los Angeles, CA, USA)

Chapter 64. Acute Kidney Injury
Jieun Kwak and Shireen Hashmat (Fellow in Neonatal-Perinatal Medicine, Department of Pediatrics, University of Southern California Medical Center, Los Angeles County, CA, USA, and others)

Chapter 65. Nephrotoxic Medications
Jieun Kwak and Shireen Hashmat (Fellow in Neonatal-Perinatal Medicine, Department of Pediatrics, University of Southern California Medical Center, Los Angeles County, CA, USA, and others)

Surgical

Chapter 66. Abdominal Wall Defects
Cristina Metildi and Alison Chu (Pediatric Surgery Fellow, Division of Pediatric Surgery, Cardinal Glennon Children's Hospital, St. Louis University
St. Louis, MO, USA, and others)

Chapter 67. Congenital Diaphragmatic Hernia
Seth Langston, Alison Chu and Cristina Metildi (Pediatric Resident, Dept of Pediatrics, University of California-Los Angeles, Mattel Children’s Hospital, LA, CA, USA, and others)

Chapter 68. Tracheoesophageal Fistula
Alison Chu, Cristina Metildi and Mario Zaritzky (Assistant Professor-in-Residence, UCLA David Geffen School of Medicine, Division of Neonatology & Developmental Biology, Dept. of Pediatrics, Los Angeles, CA, USA, and others)

Other Neonatal Topics

Chapter 69. Retinopathy of Prematurity
William MacKendrick, Peter Rabiah and Christina Kim (Head, Division of Neonatology and Vice-Chair, Dept. of Pediatrics, NorthShore University HealthSystem, Clinical Associate Professor of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL, USA, and others)

Chapter 70. Newborn Screening
C. Lydia Wraight (Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA)

Chapter 71. Neonatal Medication Considerations
Deborah S. Bondi and Kirsten H. Ohler (Clinical Pharmacy Specialist - Neonatal Intensive Care Unit, Department of Pharmacy, The University of Chicago Medicine, Comer Children's Hospital, Chicago, IL, USA, and others)

Chapter 72. Genetic Evaluation in the Neonatal Intensive Care Unit
Joan Stoler (Assistant Professor of Pediatrics, Harvard Medical School, Clinical Geneticist, Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA)

Chapter 73. Ethics in the NICU
Dalia M Feltman (Attending Neonatologist, NorthShore University HealthSystem, Evanston Hospital, Department of Pediatrics, Division of Neonatology, Senior Clinician Educator, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA)

Chapter 74. Developmental Care in the Neonatal Intensive Care Unit
Amanda Erman and Samantha Wroblewski (Clinical Nurse Educator, Stephen Neonatal Intensive Care Unit, Comer Children’s Hospital, University of Chicago
Chicago, IL, USA, and others)

Index

Audience: Pediatricians, pediatric residents, neonatal intensive care nurses, neonatal nurse practitioners, neonatologists (in private practice, in academic institutions, in community NICUs), neonatal intensive care fellows

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